TY - JOUR
T1 - Phencyclidine-induced dopamine-dependent behaviors in chronic haloperidol-treated rats
AU - Yamaguchi, Kazumasa
AU - Nabeshima, Toshitaka
AU - Amano, Manabu
AU - Yoshida, Shigeru
AU - Furukawa, Hiroshi
AU - Kameyama, Tsutomu
N1 - Funding Information:
This work was supported in part by grants-in-aid from The Ministry of Education, Science and Culture, Japan (No. 57570089), The Ishida Foundation (No. 59-292) and The Mochida Memorial Foundation for Medical and Pharmaceutical Research (No. 59-2-7) to T.N.
PY - 1985/11
Y1 - 1985/11
N2 - This study was designed to assess whether phencyclidine (PCP) produces dopamine (DA)-dependent behaviors such as licking, biting and gnawing at low doses after withdrawal from chronic haloperidol (HAL) treatment in rats. Low doses of PCP (2.5 and 5 mg/kg) produced licking, gnawing, biting and self-biting in rats after withdrawal from chronic HAL treatment, which were not observed in the vehicle-pretreated rats given PCP at the same dose range. These behaviors were similar to DA-dependent behaviors produced by methamphetamine and apomorphine in rats after withdrawal from chronic HAL treatment. The PCP-induced behaviors were attenuated by acute pretreatment of DA antagonist, HAL (0.25 mg/kg, IP). Furthermore, at doses of 5 or 7.5 mg/kg, PCP-induced head weaving and backpedalling, which were mediated by both DA and serotonin (5-HT) neurons, significantly increased in rats after withdrawal from chronic HAL-treatment. These results suggest that dopaminergic systems play an important role for PCP-induced behavioral responses.
AB - This study was designed to assess whether phencyclidine (PCP) produces dopamine (DA)-dependent behaviors such as licking, biting and gnawing at low doses after withdrawal from chronic haloperidol (HAL) treatment in rats. Low doses of PCP (2.5 and 5 mg/kg) produced licking, gnawing, biting and self-biting in rats after withdrawal from chronic HAL treatment, which were not observed in the vehicle-pretreated rats given PCP at the same dose range. These behaviors were similar to DA-dependent behaviors produced by methamphetamine and apomorphine in rats after withdrawal from chronic HAL treatment. The PCP-induced behaviors were attenuated by acute pretreatment of DA antagonist, HAL (0.25 mg/kg, IP). Furthermore, at doses of 5 or 7.5 mg/kg, PCP-induced head weaving and backpedalling, which were mediated by both DA and serotonin (5-HT) neurons, significantly increased in rats after withdrawal from chronic HAL-treatment. These results suggest that dopaminergic systems play an important role for PCP-induced behavioral responses.
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U2 - 10.1016/0091-3057(85)90075-9
DO - 10.1016/0091-3057(85)90075-9
M3 - Article
C2 - 4080767
AN - SCOPUS:0022380418
SN - 0091-3057
VL - 23
SP - 803
EP - 809
JO - Pharmacology, Biochemistry and Behavior
JF - Pharmacology, Biochemistry and Behavior
IS - 5
ER -