Phencyclidine-induced dopamine-dependent behaviors in chronic haloperidol-treated rats

Kazumasa Yamaguchi, Toshitaka Nabeshima, Manabu Amano, Shigeru Yoshida, Hiroshi Furukawa, Tsutomu Kameyama

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

This study was designed to assess whether phencyclidine (PCP) produces dopamine (DA)-dependent behaviors such as licking, biting and gnawing at low doses after withdrawal from chronic haloperidol (HAL) treatment in rats. Low doses of PCP (2.5 and 5 mg/kg) produced licking, gnawing, biting and self-biting in rats after withdrawal from chronic HAL treatment, which were not observed in the vehicle-pretreated rats given PCP at the same dose range. These behaviors were similar to DA-dependent behaviors produced by methamphetamine and apomorphine in rats after withdrawal from chronic HAL treatment. The PCP-induced behaviors were attenuated by acute pretreatment of DA antagonist, HAL (0.25 mg/kg, IP). Furthermore, at doses of 5 or 7.5 mg/kg, PCP-induced head weaving and backpedalling, which were mediated by both DA and serotonin (5-HT) neurons, significantly increased in rats after withdrawal from chronic HAL-treatment. These results suggest that dopaminergic systems play an important role for PCP-induced behavioral responses.

Original languageEnglish
Pages (from-to)803-809
Number of pages7
JournalPharmacology, Biochemistry and Behavior
Volume23
Issue number5
DOIs
Publication statusPublished - 01-01-1985
Externally publishedYes

Fingerprint

Phencyclidine
Haloperidol
Rats
Dopamine
Serotonin
Dopamine Antagonists
Methamphetamine
Apomorphine
Neurons
Head

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

Cite this

Yamaguchi, Kazumasa ; Nabeshima, Toshitaka ; Amano, Manabu ; Yoshida, Shigeru ; Furukawa, Hiroshi ; Kameyama, Tsutomu. / Phencyclidine-induced dopamine-dependent behaviors in chronic haloperidol-treated rats. In: Pharmacology, Biochemistry and Behavior. 1985 ; Vol. 23, No. 5. pp. 803-809.
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abstract = "This study was designed to assess whether phencyclidine (PCP) produces dopamine (DA)-dependent behaviors such as licking, biting and gnawing at low doses after withdrawal from chronic haloperidol (HAL) treatment in rats. Low doses of PCP (2.5 and 5 mg/kg) produced licking, gnawing, biting and self-biting in rats after withdrawal from chronic HAL treatment, which were not observed in the vehicle-pretreated rats given PCP at the same dose range. These behaviors were similar to DA-dependent behaviors produced by methamphetamine and apomorphine in rats after withdrawal from chronic HAL treatment. The PCP-induced behaviors were attenuated by acute pretreatment of DA antagonist, HAL (0.25 mg/kg, IP). Furthermore, at doses of 5 or 7.5 mg/kg, PCP-induced head weaving and backpedalling, which were mediated by both DA and serotonin (5-HT) neurons, significantly increased in rats after withdrawal from chronic HAL-treatment. These results suggest that dopaminergic systems play an important role for PCP-induced behavioral responses.",
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Phencyclidine-induced dopamine-dependent behaviors in chronic haloperidol-treated rats. / Yamaguchi, Kazumasa; Nabeshima, Toshitaka; Amano, Manabu; Yoshida, Shigeru; Furukawa, Hiroshi; Kameyama, Tsutomu.

In: Pharmacology, Biochemistry and Behavior, Vol. 23, No. 5, 01.01.1985, p. 803-809.

Research output: Contribution to journalArticle

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