Phencyclidine-induced expression of c-Fos-like immunoreactivity in mouse brain regions

Souhei Sugita, Misako Namima, Toshitaka Nabeshima, Koichi Okamoto, Hiroshi Furukawa, Yasuhiro Watanabe

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

For the purpose of studying a role of immediate early genes in psychotomimetic-induced behavioral excitation, we experimentally enhanced the locomotor activity of mice by acute administration of phencyclidine and examined the expression and localization of the c-Fos-like and c-Jun-like immunoreactivities in brain regions. A single injection of phencyclidine (5.0 mg/kg, i.p.) significantly increased not only the locomotor activity but also the expression of c-Fos-like immunoreactivity in several brain regions, particularly in the parietal cortex, hippocampal dentate gyrus, piriform cortex and hypothalamus. Interestingly, the c-Fos-like immunoreactivity in the parietal cortex continued to increase for 1 week after the phencyclidine injection. These results indicate that phencyclidine, even injected only once, can induce the persistent expression of c-Fos or c-Fos-related protein(s) in the mouse brain, and also suggest the possibility that such a c-Fos expression may underlie the behavioral and/or psychotomimetic effects of phencyclidine.

Original languageEnglish
Pages (from-to)545-550
Number of pages6
JournalNeurochemistry International
Volume28
Issue number5-6
DOIs
Publication statusPublished - 01-01-1996
Externally publishedYes

Fingerprint

Phencyclidine
Brain
Parietal Lobe
Locomotion
Proto-Oncogene Proteins c-fos
Parahippocampal Gyrus
Injections
Immediate-Early Genes
Dentate Gyrus
Hypothalamus

All Science Journal Classification (ASJC) codes

  • Cellular and Molecular Neuroscience
  • Cell Biology

Cite this

Sugita, Souhei ; Namima, Misako ; Nabeshima, Toshitaka ; Okamoto, Koichi ; Furukawa, Hiroshi ; Watanabe, Yasuhiro. / Phencyclidine-induced expression of c-Fos-like immunoreactivity in mouse brain regions. In: Neurochemistry International. 1996 ; Vol. 28, No. 5-6. pp. 545-550.
@article{c5b6fe4107b7404ea622b086bc775a92,
title = "Phencyclidine-induced expression of c-Fos-like immunoreactivity in mouse brain regions",
abstract = "For the purpose of studying a role of immediate early genes in psychotomimetic-induced behavioral excitation, we experimentally enhanced the locomotor activity of mice by acute administration of phencyclidine and examined the expression and localization of the c-Fos-like and c-Jun-like immunoreactivities in brain regions. A single injection of phencyclidine (5.0 mg/kg, i.p.) significantly increased not only the locomotor activity but also the expression of c-Fos-like immunoreactivity in several brain regions, particularly in the parietal cortex, hippocampal dentate gyrus, piriform cortex and hypothalamus. Interestingly, the c-Fos-like immunoreactivity in the parietal cortex continued to increase for 1 week after the phencyclidine injection. These results indicate that phencyclidine, even injected only once, can induce the persistent expression of c-Fos or c-Fos-related protein(s) in the mouse brain, and also suggest the possibility that such a c-Fos expression may underlie the behavioral and/or psychotomimetic effects of phencyclidine.",
author = "Souhei Sugita and Misako Namima and Toshitaka Nabeshima and Koichi Okamoto and Hiroshi Furukawa and Yasuhiro Watanabe",
year = "1996",
month = "1",
day = "1",
doi = "10.1016/0197-0186(95)00127-1",
language = "English",
volume = "28",
pages = "545--550",
journal = "Neurochemistry International",
issn = "0197-0186",
publisher = "Elsevier Limited",
number = "5-6",

}

Phencyclidine-induced expression of c-Fos-like immunoreactivity in mouse brain regions. / Sugita, Souhei; Namima, Misako; Nabeshima, Toshitaka; Okamoto, Koichi; Furukawa, Hiroshi; Watanabe, Yasuhiro.

In: Neurochemistry International, Vol. 28, No. 5-6, 01.01.1996, p. 545-550.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Phencyclidine-induced expression of c-Fos-like immunoreactivity in mouse brain regions

AU - Sugita, Souhei

AU - Namima, Misako

AU - Nabeshima, Toshitaka

AU - Okamoto, Koichi

AU - Furukawa, Hiroshi

AU - Watanabe, Yasuhiro

PY - 1996/1/1

Y1 - 1996/1/1

N2 - For the purpose of studying a role of immediate early genes in psychotomimetic-induced behavioral excitation, we experimentally enhanced the locomotor activity of mice by acute administration of phencyclidine and examined the expression and localization of the c-Fos-like and c-Jun-like immunoreactivities in brain regions. A single injection of phencyclidine (5.0 mg/kg, i.p.) significantly increased not only the locomotor activity but also the expression of c-Fos-like immunoreactivity in several brain regions, particularly in the parietal cortex, hippocampal dentate gyrus, piriform cortex and hypothalamus. Interestingly, the c-Fos-like immunoreactivity in the parietal cortex continued to increase for 1 week after the phencyclidine injection. These results indicate that phencyclidine, even injected only once, can induce the persistent expression of c-Fos or c-Fos-related protein(s) in the mouse brain, and also suggest the possibility that such a c-Fos expression may underlie the behavioral and/or psychotomimetic effects of phencyclidine.

AB - For the purpose of studying a role of immediate early genes in psychotomimetic-induced behavioral excitation, we experimentally enhanced the locomotor activity of mice by acute administration of phencyclidine and examined the expression and localization of the c-Fos-like and c-Jun-like immunoreactivities in brain regions. A single injection of phencyclidine (5.0 mg/kg, i.p.) significantly increased not only the locomotor activity but also the expression of c-Fos-like immunoreactivity in several brain regions, particularly in the parietal cortex, hippocampal dentate gyrus, piriform cortex and hypothalamus. Interestingly, the c-Fos-like immunoreactivity in the parietal cortex continued to increase for 1 week after the phencyclidine injection. These results indicate that phencyclidine, even injected only once, can induce the persistent expression of c-Fos or c-Fos-related protein(s) in the mouse brain, and also suggest the possibility that such a c-Fos expression may underlie the behavioral and/or psychotomimetic effects of phencyclidine.

UR - http://www.scopus.com/inward/record.url?scp=0030010699&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030010699&partnerID=8YFLogxK

U2 - 10.1016/0197-0186(95)00127-1

DO - 10.1016/0197-0186(95)00127-1

M3 - Article

C2 - 8792335

AN - SCOPUS:0030010699

VL - 28

SP - 545

EP - 550

JO - Neurochemistry International

JF - Neurochemistry International

SN - 0197-0186

IS - 5-6

ER -