TY - JOUR
T1 - Phencyclidine-induced expression of c-Fos-like immunoreactivity in mouse brain regions
AU - Sugita, Souhei
AU - Namima, Misako
AU - Nabeshima, Toshitaka
AU - Okamoto, Koichi
AU - Furukawa, Hiroshi
AU - Watanabe, Yasuhiro
N1 - Funding Information:
Acknowled, qements This work was supported by grants from The Ichiro Kanehara Foundation and The Epilepsy Research Foundation of Japan.
PY - 1996
Y1 - 1996
N2 - For the purpose of studying a role of immediate early genes in psychotomimetic-induced behavioral excitation, we experimentally enhanced the locomotor activity of mice by acute administration of phencyclidine and examined the expression and localization of the c-Fos-like and c-Jun-like immunoreactivities in brain regions. A single injection of phencyclidine (5.0 mg/kg, i.p.) significantly increased not only the locomotor activity but also the expression of c-Fos-like immunoreactivity in several brain regions, particularly in the parietal cortex, hippocampal dentate gyrus, piriform cortex and hypothalamus. Interestingly, the c-Fos-like immunoreactivity in the parietal cortex continued to increase for 1 week after the phencyclidine injection. These results indicate that phencyclidine, even injected only once, can induce the persistent expression of c-Fos or c-Fos-related protein(s) in the mouse brain, and also suggest the possibility that such a c-Fos expression may underlie the behavioral and/or psychotomimetic effects of phencyclidine.
AB - For the purpose of studying a role of immediate early genes in psychotomimetic-induced behavioral excitation, we experimentally enhanced the locomotor activity of mice by acute administration of phencyclidine and examined the expression and localization of the c-Fos-like and c-Jun-like immunoreactivities in brain regions. A single injection of phencyclidine (5.0 mg/kg, i.p.) significantly increased not only the locomotor activity but also the expression of c-Fos-like immunoreactivity in several brain regions, particularly in the parietal cortex, hippocampal dentate gyrus, piriform cortex and hypothalamus. Interestingly, the c-Fos-like immunoreactivity in the parietal cortex continued to increase for 1 week after the phencyclidine injection. These results indicate that phencyclidine, even injected only once, can induce the persistent expression of c-Fos or c-Fos-related protein(s) in the mouse brain, and also suggest the possibility that such a c-Fos expression may underlie the behavioral and/or psychotomimetic effects of phencyclidine.
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U2 - 10.1016/0197-0186(95)00127-1
DO - 10.1016/0197-0186(95)00127-1
M3 - Article
C2 - 8792335
AN - SCOPUS:0030010699
SN - 0197-0186
VL - 28
SP - 545
EP - 550
JO - Neurochemistry International
JF - Neurochemistry International
IS - 5-6
ER -