Phencyclidine-induced head-twitch responses as 5-HT2 receptor-mediated behavior in rats

Toshitaka Nabeshima; Kazuhiro Ishikawa; Kazumasa Yamaguchi; Hiroshi Furukawa; Tsutomu Kameyama

doi:10.1016/0304-3940(87)90425-3

Phencyclidine-induced head-twitch responses as 5-HT₂ receptor-mediated behavior in rats

Toshitaka Nabeshima, Kazuhiro Ishikawa, Kazumasa Yamaguchi, Hiroshi Furukawa, Tsutomu Kameyama

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

Abstract

This study was designed to assess whether phencyclidine (PCP)-induced head-twitch was antagonized by ritanserin, a selective serotonin (5-HT₂) receptor antagonist, in mice and rats to confirm the involvement of 5-hydroxytryptamine (5-HT) neurons in PCP actions in comparison with 5-methoxy-N,N-dimethyltryptamine (5-MeODMT)-induced behavior. PCP (7.5, 10 and 12.5 mg/kg. i.p.)-induced head-twitch was completely antagonized by ritanserin (1 mg/kg, s.c.) in mice and rats, and 5-MeODMT (2 and 4 mg/kg, i.p.)-induced head-twitch was also completely antagonized by ritanserin in mice. PCP and 5-MeODMT induced head-weaving in mice after ritanserin treatment, but this did not occur in rats. In rats, 5-MeODMT failed to induce head-twitch. These results suggest that PCP-induced head-twitch response in rats is developed via 5-HT₂ receptors and it is a useful 5-HT₂ receptor model, while 5-MeODMT-induced head-weaving in rats is developed via 5-HT₁ receptors and is a useful 5-HT₁ receptor model.

Original language	English
Pages (from-to)	335-338
Number of pages	4
Journal	Neuroscience Letters
Volume	76
Issue number	3
DOIs	https://doi.org/10.1016/0304-3940(87)90425-3
Publication status	Published - 19-05-1987
Externally published	Yes

All Science Journal Classification (ASJC) codes

Neuroscience(all)

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@article{d8dc36f40fda497d9f930449bdc2bfc1,

title = "Phencyclidine-induced head-twitch responses as 5-HT2 receptor-mediated behavior in rats",

abstract = "This study was designed to assess whether phencyclidine (PCP)-induced head-twitch was antagonized by ritanserin, a selective serotonin (5-HT2) receptor antagonist, in mice and rats to confirm the involvement of 5-hydroxytryptamine (5-HT) neurons in PCP actions in comparison with 5-methoxy-N,N-dimethyltryptamine (5-MeODMT)-induced behavior. PCP (7.5, 10 and 12.5 mg/kg. i.p.)-induced head-twitch was completely antagonized by ritanserin (1 mg/kg, s.c.) in mice and rats, and 5-MeODMT (2 and 4 mg/kg, i.p.)-induced head-twitch was also completely antagonized by ritanserin in mice. PCP and 5-MeODMT induced head-weaving in mice after ritanserin treatment, but this did not occur in rats. In rats, 5-MeODMT failed to induce head-twitch. These results suggest that PCP-induced head-twitch response in rats is developed via 5-HT2 receptors and it is a useful 5-HT2 receptor model, while 5-MeODMT-induced head-weaving in rats is developed via 5-HT1 receptors and is a useful 5-HT1 receptor model.",

author = "Toshitaka Nabeshima and Kazuhiro Ishikawa and Kazumasa Yamaguchi and Hiroshi Furukawa and Tsutomu Kameyama",

note = "Funding Information: This study was supported in part by grants-in-aid from 1986 Incentive Award of Pharmaceutical Society of Japan. The Research Foundation lbr Pharmaceutical Sciences (59-1-12), The Ministry of Education, Science and Culture, Japan (60570100), and The Science Research Promotion Foundation of Japan Private School Promotion Foundation (1986-I l). We are grateful to Janssen-Kyowa for their gift of ritanserin. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.",

year = "1987",

month = may,

day = "19",

doi = "10.1016/0304-3940(87)90425-3",

language = "English",

volume = "76",

pages = "335--338",

journal = "Neuroscience Letters",

issn = "0304-3940",

publisher = "Elsevier Ireland Ltd",

number = "3",

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TY - JOUR

T1 - Phencyclidine-induced head-twitch responses as 5-HT2 receptor-mediated behavior in rats

AU - Nabeshima, Toshitaka

AU - Ishikawa, Kazuhiro

AU - Yamaguchi, Kazumasa

AU - Furukawa, Hiroshi

AU - Kameyama, Tsutomu

N1 - Funding Information: This study was supported in part by grants-in-aid from 1986 Incentive Award of Pharmaceutical Society of Japan. The Research Foundation lbr Pharmaceutical Sciences (59-1-12), The Ministry of Education, Science and Culture, Japan (60570100), and The Science Research Promotion Foundation of Japan Private School Promotion Foundation (1986-I l). We are grateful to Janssen-Kyowa for their gift of ritanserin. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.

PY - 1987/5/19

Y1 - 1987/5/19

N2 - This study was designed to assess whether phencyclidine (PCP)-induced head-twitch was antagonized by ritanserin, a selective serotonin (5-HT2) receptor antagonist, in mice and rats to confirm the involvement of 5-hydroxytryptamine (5-HT) neurons in PCP actions in comparison with 5-methoxy-N,N-dimethyltryptamine (5-MeODMT)-induced behavior. PCP (7.5, 10 and 12.5 mg/kg. i.p.)-induced head-twitch was completely antagonized by ritanserin (1 mg/kg, s.c.) in mice and rats, and 5-MeODMT (2 and 4 mg/kg, i.p.)-induced head-twitch was also completely antagonized by ritanserin in mice. PCP and 5-MeODMT induced head-weaving in mice after ritanserin treatment, but this did not occur in rats. In rats, 5-MeODMT failed to induce head-twitch. These results suggest that PCP-induced head-twitch response in rats is developed via 5-HT2 receptors and it is a useful 5-HT2 receptor model, while 5-MeODMT-induced head-weaving in rats is developed via 5-HT1 receptors and is a useful 5-HT1 receptor model.

AB - This study was designed to assess whether phencyclidine (PCP)-induced head-twitch was antagonized by ritanserin, a selective serotonin (5-HT2) receptor antagonist, in mice and rats to confirm the involvement of 5-hydroxytryptamine (5-HT) neurons in PCP actions in comparison with 5-methoxy-N,N-dimethyltryptamine (5-MeODMT)-induced behavior. PCP (7.5, 10 and 12.5 mg/kg. i.p.)-induced head-twitch was completely antagonized by ritanserin (1 mg/kg, s.c.) in mice and rats, and 5-MeODMT (2 and 4 mg/kg, i.p.)-induced head-twitch was also completely antagonized by ritanserin in mice. PCP and 5-MeODMT induced head-weaving in mice after ritanserin treatment, but this did not occur in rats. In rats, 5-MeODMT failed to induce head-twitch. These results suggest that PCP-induced head-twitch response in rats is developed via 5-HT2 receptors and it is a useful 5-HT2 receptor model, while 5-MeODMT-induced head-weaving in rats is developed via 5-HT1 receptors and is a useful 5-HT1 receptor model.

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U2 - 10.1016/0304-3940(87)90425-3

DO - 10.1016/0304-3940(87)90425-3

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VL - 76

SP - 335

EP - 338

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

IS - 3