Phencyclidine-induced head-twitch responses as 5-HT2 receptor-mediated behavior in rats

Toshitaka Nabeshima, Kazuhiro Ishikawa, Kazumasa Yamaguchi, Hiroshi Furukawa, Tsutomu Kameyama

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

This study was designed to assess whether phencyclidine (PCP)-induced head-twitch was antagonized by ritanserin, a selective serotonin (5-HT2) receptor antagonist, in mice and rats to confirm the involvement of 5-hydroxytryptamine (5-HT) neurons in PCP actions in comparison with 5-methoxy-N,N-dimethyltryptamine (5-MeODMT)-induced behavior. PCP (7.5, 10 and 12.5 mg/kg. i.p.)-induced head-twitch was completely antagonized by ritanserin (1 mg/kg, s.c.) in mice and rats, and 5-MeODMT (2 and 4 mg/kg, i.p.)-induced head-twitch was also completely antagonized by ritanserin in mice. PCP and 5-MeODMT induced head-weaving in mice after ritanserin treatment, but this did not occur in rats. In rats, 5-MeODMT failed to induce head-twitch. These results suggest that PCP-induced head-twitch response in rats is developed via 5-HT2 receptors and it is a useful 5-HT2 receptor model, while 5-MeODMT-induced head-weaving in rats is developed via 5-HT1 receptors and is a useful 5-HT1 receptor model.

Original languageEnglish
Pages (from-to)335-338
Number of pages4
JournalNeuroscience Letters
Volume76
Issue number3
DOIs
Publication statusPublished - 19-05-1987
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Fingerprint Dive into the research topics of 'Phencyclidine-induced head-twitch responses as 5-HT<sub>2</sub> receptor-mediated behavior in rats'. Together they form a unique fingerprint.

  • Cite this

    Nabeshima, T., Ishikawa, K., Yamaguchi, K., Furukawa, H., & Kameyama, T. (1987). Phencyclidine-induced head-twitch responses as 5-HT2 receptor-mediated behavior in rats. Neuroscience Letters, 76(3), 335-338. https://doi.org/10.1016/0304-3940(87)90425-3