Phencyclidine-induced head-twitch responses as 5-HT2 receptor-mediated behavior in rats

Toshitaka Nabeshima, Kazuhiro Ishikawa, Kazumasa Yamaguchi, Hiroshi Furukawa, Tsutomu Kameyama

Research output: Contribution to journalArticle

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Abstract

This study was designed to assess whether phencyclidine (PCP)-induced head-twitch was antagonized by ritanserin, a selective serotonin (5-HT2) receptor antagonist, in mice and rats to confirm the involvement of 5-hydroxytryptamine (5-HT) neurons in PCP actions in comparison with 5-methoxy-N,N-dimethyltryptamine (5-MeODMT)-induced behavior. PCP (7.5, 10 and 12.5 mg/kg. i.p.)-induced head-twitch was completely antagonized by ritanserin (1 mg/kg, s.c.) in mice and rats, and 5-MeODMT (2 and 4 mg/kg, i.p.)-induced head-twitch was also completely antagonized by ritanserin in mice. PCP and 5-MeODMT induced head-weaving in mice after ritanserin treatment, but this did not occur in rats. In rats, 5-MeODMT failed to induce head-twitch. These results suggest that PCP-induced head-twitch response in rats is developed via 5-HT2 receptors and it is a useful 5-HT2 receptor model, while 5-MeODMT-induced head-weaving in rats is developed via 5-HT1 receptors and is a useful 5-HT1 receptor model.

Original languageEnglish
Pages (from-to)335-338
Number of pages4
JournalNeuroscience Letters
Volume76
Issue number3
DOIs
Publication statusPublished - 19-05-1987
Externally publishedYes

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Phencyclidine
Methoxydimethyltryptamines
Ritanserin
Head
Serotonin 5-HT1 Receptors
Serotonin 5-HT2 Receptor Antagonists
Serotonin
Neurons

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Nabeshima, Toshitaka ; Ishikawa, Kazuhiro ; Yamaguchi, Kazumasa ; Furukawa, Hiroshi ; Kameyama, Tsutomu. / Phencyclidine-induced head-twitch responses as 5-HT2 receptor-mediated behavior in rats. In: Neuroscience Letters. 1987 ; Vol. 76, No. 3. pp. 335-338.
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Phencyclidine-induced head-twitch responses as 5-HT2 receptor-mediated behavior in rats. / Nabeshima, Toshitaka; Ishikawa, Kazuhiro; Yamaguchi, Kazumasa; Furukawa, Hiroshi; Kameyama, Tsutomu.

In: Neuroscience Letters, Vol. 76, No. 3, 19.05.1987, p. 335-338.

Research output: Contribution to journalArticle

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