Phencyclidine-induced head-weaving observed in mice after ritanserin treatment

Toshitaka Nabeshima, Kazuhiro Ishikawa, Kazumasa Yamaguchi, Hiroshi Furukawa, Tsutomu Kameyama

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Abstract

Ritanserin (0.125, 0.25, 0.5, 1.0 and 2.0 mg/kg s.c.), a selective serotonin (5-HT2) receptor antagonist, produced a dose-dependent inhibition of the head-twitch response induced in mice by phencyclidine (PCP) and 5-methoxy-N, N-dimethyltryptamine (5-MeODMT). In contrast, ritanserin, dose dependently increased PCP- and 5-MeODMT-induced head-weaving. There was a significant inverse relationship between head-twitch and head-weaving responses. Pretreatment with p-chlorophenylalanine (PCPA, 300 mg/kg i.p.), a serotonin synthesis inhibitor, attenuated the head-weaving induced by the combination of PCP (12.5 mg/kg i.p.) and ritanserin but PCPA did not alter the 5-MeODMT-induced head-weaving. These results indicate that PCP induces head-weaving by interacting with a 5-HT receptor (possibly of the 5-HT1 subtype) indirectly after 5-HT release and induces head-twitch by interacting with 5-HT2 receptors directly.

Original languageEnglish
Pages (from-to)171-178
Number of pages8
JournalEuropean Journal of Pharmacology
Volume139
Issue number2
DOIs
Publication statusPublished - 09-07-1987

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All Science Journal Classification (ASJC) codes

  • Pharmacology

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