Phencyclidine-induced head-weaving observed in mice after ritanserin treatment

Toshitaka Nabeshima, Kazuhiro Ishikawa, Kazumasa Yamaguchi, Hiroshi Furukawa, Tsutomu Kameyama

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Ritanserin (0.125, 0.25, 0.5, 1.0 and 2.0 mg/kg s.c.), a selective serotonin (5-HT2) receptor antagonist, produced a dose-dependent inhibition of the head-twitch response induced in mice by phencyclidine (PCP) and 5-methoxy-N, N-dimethyltryptamine (5-MeODMT). In contrast, ritanserin, dose dependently increased PCP- and 5-MeODMT-induced head-weaving. There was a significant inverse relationship between head-twitch and head-weaving responses. Pretreatment with p-chlorophenylalanine (PCPA, 300 mg/kg i.p.), a serotonin synthesis inhibitor, attenuated the head-weaving induced by the combination of PCP (12.5 mg/kg i.p.) and ritanserin but PCPA did not alter the 5-MeODMT-induced head-weaving. These results indicate that PCP induces head-weaving by interacting with a 5-HT receptor (possibly of the 5-HT1 subtype) indirectly after 5-HT release and induces head-twitch by interacting with 5-HT2 receptors directly.

Original languageEnglish
Pages (from-to)171-178
Number of pages8
JournalEuropean Journal of Pharmacology
Volume139
Issue number2
DOIs
Publication statusPublished - 09-07-1987
Externally publishedYes

Fingerprint

Ritanserin
Phencyclidine
Head
Methoxydimethyltryptamines
Serotonin
Fenclonine
Serotonin 5-HT2 Receptor Antagonists
Serotonin Receptors

All Science Journal Classification (ASJC) codes

  • Pharmacology

Cite this

Nabeshima, Toshitaka ; Ishikawa, Kazuhiro ; Yamaguchi, Kazumasa ; Furukawa, Hiroshi ; Kameyama, Tsutomu. / Phencyclidine-induced head-weaving observed in mice after ritanserin treatment. In: European Journal of Pharmacology. 1987 ; Vol. 139, No. 2. pp. 171-178.
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Phencyclidine-induced head-weaving observed in mice after ritanserin treatment. / Nabeshima, Toshitaka; Ishikawa, Kazuhiro; Yamaguchi, Kazumasa; Furukawa, Hiroshi; Kameyama, Tsutomu.

In: European Journal of Pharmacology, Vol. 139, No. 2, 09.07.1987, p. 171-178.

Research output: Contribution to journalArticle

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AU - Ishikawa, Kazuhiro

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AU - Kameyama, Tsutomu

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