TY - JOUR
T1 - Phencyclidine-induced stereotyped behaviors after injection of ethylketocyclazocine, Mr 2266 and naltrexone in rats
AU - Nabeshima, Toshitaka
AU - Hiramatsu, Masayuki
AU - Kameyama, Tsutomu
N1 - Funding Information:
This study was supported in part by grants-in-aid from The Ishida Foundation (59-292), The Mochida Memorial Foundation for Medical and Pharmaceutical Research (59-2-7), The Research Foundation for Pharmaceutical Sciences (59-1-12) and The Ministry of Education, Science and Culture, Japan (60570100). We thank Mr. K. Yamaguchi, Nihon Bioresearch Center Inc. for the supply of animals and Miss N. Ito for her technical support. Ethylketocyclazocine, Mr 2266, naltrexone and phencyclidine were generously supplied by Sterling Winthrop, Boehringer Ingelheim, Dupont Pharm. and Dr. Fu-rukawa, respectively. We also thank Mr. W. Petrus-chak for the English revision of the manuscript.
PY - 1986/7/23
Y1 - 1986/7/23
N2 - The effects of ethylketocyclazocine (EKC), Mr 2266 and naltrexone on the stereotyped behaviors induced by an intraperitoneal injection of phencyclidine (PCP) were examined. PCP-induced turning, backpedalling, head weaving and sniffing were antagonized by pretreatment with EKC (0.25-4.0 mg/kg). While pretreatment with Mr 2266 (2.5 mg/kg), a χ selective antagonist, and naltrexone (10 mg/kg), a μ selective antagonist, failed to affect the PCP-induced stereotypy, Mr 2266 antagonized the suppressing effect of EKC on PCP-induced stereotypy. Taken into consideration, this suggests that χ opioid agonists such as EKC antagonize PCP-induced stereotyped behaviors through a χ opioid mechanism, and that the μ opioid receptor may not play an important role in the PCP-induced stereotypy in rats.
AB - The effects of ethylketocyclazocine (EKC), Mr 2266 and naltrexone on the stereotyped behaviors induced by an intraperitoneal injection of phencyclidine (PCP) were examined. PCP-induced turning, backpedalling, head weaving and sniffing were antagonized by pretreatment with EKC (0.25-4.0 mg/kg). While pretreatment with Mr 2266 (2.5 mg/kg), a χ selective antagonist, and naltrexone (10 mg/kg), a μ selective antagonist, failed to affect the PCP-induced stereotypy, Mr 2266 antagonized the suppressing effect of EKC on PCP-induced stereotypy. Taken into consideration, this suggests that χ opioid agonists such as EKC antagonize PCP-induced stereotyped behaviors through a χ opioid mechanism, and that the μ opioid receptor may not play an important role in the PCP-induced stereotypy in rats.
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U2 - 10.1016/0006-8993(86)90926-1
DO - 10.1016/0006-8993(86)90926-1
M3 - Article
C2 - 3015356
AN - SCOPUS:0022494160
SN - 0006-8993
VL - 378
SP - 234
EP - 239
JO - Brain Research
JF - Brain Research
IS - 2
ER -