Phencyclidine-induced stereotyped behaviors after injection of ethylketocyclazocine, Mr 2266 and naltrexone in rats

Toshitaka Nabeshima, Masayuki Hiramatsu, Tsutomu Kameyama

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The effects of ethylketocyclazocine (EKC), Mr 2266 and naltrexone on the stereotyped behaviors induced by an intraperitoneal injection of phencyclidine (PCP) were examined. PCP-induced turning, backpedalling, head weaving and sniffing were antagonized by pretreatment with EKC (0.25-4.0 mg/kg). While pretreatment with Mr 2266 (2.5 mg/kg), a χ selective antagonist, and naltrexone (10 mg/kg), a μ selective antagonist, failed to affect the PCP-induced stereotypy, Mr 2266 antagonized the suppressing effect of EKC on PCP-induced stereotypy. Taken into consideration, this suggests that χ opioid agonists such as EKC antagonize PCP-induced stereotyped behaviors through a χ opioid mechanism, and that the μ opioid receptor may not play an important role in the PCP-induced stereotypy in rats.

Original languageEnglish
Pages (from-to)234-239
Number of pages6
JournalBrain Research
Volume378
Issue number2
DOIs
Publication statusPublished - 23-07-1986
Externally publishedYes

Fingerprint

Ethylketocyclazocine
Stereotyped Behavior
Phencyclidine
Naltrexone
Injections
Opioid Analgesics
Opioid Receptors
Intraperitoneal Injections
Head

All Science Journal Classification (ASJC) codes

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

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abstract = "The effects of ethylketocyclazocine (EKC), Mr 2266 and naltrexone on the stereotyped behaviors induced by an intraperitoneal injection of phencyclidine (PCP) were examined. PCP-induced turning, backpedalling, head weaving and sniffing were antagonized by pretreatment with EKC (0.25-4.0 mg/kg). While pretreatment with Mr 2266 (2.5 mg/kg), a χ selective antagonist, and naltrexone (10 mg/kg), a μ selective antagonist, failed to affect the PCP-induced stereotypy, Mr 2266 antagonized the suppressing effect of EKC on PCP-induced stereotypy. Taken into consideration, this suggests that χ opioid agonists such as EKC antagonize PCP-induced stereotyped behaviors through a χ opioid mechanism, and that the μ opioid receptor may not play an important role in the PCP-induced stereotypy in rats.",
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Phencyclidine-induced stereotyped behaviors after injection of ethylketocyclazocine, Mr 2266 and naltrexone in rats. / Nabeshima, Toshitaka; Hiramatsu, Masayuki; Kameyama, Tsutomu.

In: Brain Research, Vol. 378, No. 2, 23.07.1986, p. 234-239.

Research output: Contribution to journalArticle

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AB - The effects of ethylketocyclazocine (EKC), Mr 2266 and naltrexone on the stereotyped behaviors induced by an intraperitoneal injection of phencyclidine (PCP) were examined. PCP-induced turning, backpedalling, head weaving and sniffing were antagonized by pretreatment with EKC (0.25-4.0 mg/kg). While pretreatment with Mr 2266 (2.5 mg/kg), a χ selective antagonist, and naltrexone (10 mg/kg), a μ selective antagonist, failed to affect the PCP-induced stereotypy, Mr 2266 antagonized the suppressing effect of EKC on PCP-induced stereotypy. Taken into consideration, this suggests that χ opioid agonists such as EKC antagonize PCP-induced stereotyped behaviors through a χ opioid mechanism, and that the μ opioid receptor may not play an important role in the PCP-induced stereotypy in rats.

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