TY - JOUR
T1 - Phencyclidine-induced stereotyped behaviors after injection of morphine and N-allylnormetazocine (SKF 10,047) in rats
AU - Nabeshima, Toshitaka
AU - Hiramatsu, Masayuki
AU - Kameyama, Tsutomu
N1 - Funding Information:
This study was supported in part by grants-in-aid from The Ishida Foundation (#59-292), The Mochida Memorial Foundation for Medical and Pharmaceutical Research (#59-2-7), The Research Foundation for Pharmaceutical Sciences (#59-1-12) and The Ministry of Education, Science and Culture, Japan (#60570100). We thank Mr. K. Yamaguchi, Nihon Bioresearch Center Inc., for supplying animals and also thank Miss Noriko Ito for her technical support. Phencyclidine and SKF 10,047 were generously supplied by Dr. H. Furukawa (Meijo University, Japan) and the National Institute on Drug Abuse (Rockville, MD), respectively. We also thank Mr. W. Petruschak for the English revision of the manuscript.
PY - 1986/6
Y1 - 1986/6
N2 - We investigated the effects of N-allylnormetazocine (SKF 10,047) and morphine on the stereotyped behaviors induced by the intraperitioneal injection of phencyclidine (PCP). PCP-induced turning and backpedalling were significantly potentiated by pretreatment with SKF 10,047 (10 mg/kg) but sniffing and head weaving were not. On the other hand, pretreatment with morphine dose-dependently attenuated PCP-induced sniffing and head weaving, but not turning and backpedalling. These results suggest that PCP-induced stereotypy may be mediated by not only a sigma opioid receptor but also some other receptors. In addition, each component of PCP-induced stereotypy may be controlled by different opioid systems and/or neuronal systems.
AB - We investigated the effects of N-allylnormetazocine (SKF 10,047) and morphine on the stereotyped behaviors induced by the intraperitioneal injection of phencyclidine (PCP). PCP-induced turning and backpedalling were significantly potentiated by pretreatment with SKF 10,047 (10 mg/kg) but sniffing and head weaving were not. On the other hand, pretreatment with morphine dose-dependently attenuated PCP-induced sniffing and head weaving, but not turning and backpedalling. These results suggest that PCP-induced stereotypy may be mediated by not only a sigma opioid receptor but also some other receptors. In addition, each component of PCP-induced stereotypy may be controlled by different opioid systems and/or neuronal systems.
UR - http://www.scopus.com/inward/record.url?scp=0022482986&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0022482986&partnerID=8YFLogxK
U2 - 10.1016/0091-3057(86)90497-1
DO - 10.1016/0091-3057(86)90497-1
M3 - Article
C2 - 3016758
AN - SCOPUS:0022482986
VL - 24
SP - 1629
EP - 1634
JO - Pharmacology Biochemistry and Behavior
JF - Pharmacology Biochemistry and Behavior
SN - 0091-3057
IS - 6
ER -