Phencyclidine-induced stereotyped behaviors after injection of morphine and N-allylnormetazocine (SKF 10,047) in rats

Toshitaka Nabeshima; Masayuki Hiramatsu; Tsutomu Kameyama

doi:10.1016/0091-3057(86)90497-1

Phencyclidine-induced stereotyped behaviors after injection of morphine and N-allylnormetazocine (SKF 10,047) in rats

Toshitaka Nabeshima, Masayuki Hiramatsu, Tsutomu Kameyama

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7 Citations (Scopus)

Abstract

We investigated the effects of N-allylnormetazocine (SKF 10,047) and morphine on the stereotyped behaviors induced by the intraperitioneal injection of phencyclidine (PCP). PCP-induced turning and backpedalling were significantly potentiated by pretreatment with SKF 10,047 (10 mg/kg) but sniffing and head weaving were not. On the other hand, pretreatment with morphine dose-dependently attenuated PCP-induced sniffing and head weaving, but not turning and backpedalling. These results suggest that PCP-induced stereotypy may be mediated by not only a sigma opioid receptor but also some other receptors. In addition, each component of PCP-induced stereotypy may be controlled by different opioid systems and/or neuronal systems.

Original language	English
Pages (from-to)	1629-1634
Number of pages	6
Journal	Pharmacology, Biochemistry and Behavior
Volume	24
Issue number	6
DOIs	https://doi.org/10.1016/0091-3057(86)90497-1
Publication status	Published - 06-1986
Externally published	Yes

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All Science Journal Classification (ASJC) codes

Biochemistry
Toxicology
Pharmacology
Clinical Biochemistry
Biological Psychiatry
Behavioral Neuroscience

Cite this

Nabeshima, T., Hiramatsu, M., & Kameyama, T. (1986). Phencyclidine-induced stereotyped behaviors after injection of morphine and N-allylnormetazocine (SKF 10,047) in rats. Pharmacology, Biochemistry and Behavior, 24(6), 1629-1634. https://doi.org/10.1016/0091-3057(86)90497-1

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abstract = "We investigated the effects of N-allylnormetazocine (SKF 10,047) and morphine on the stereotyped behaviors induced by the intraperitioneal injection of phencyclidine (PCP). PCP-induced turning and backpedalling were significantly potentiated by pretreatment with SKF 10,047 (10 mg/kg) but sniffing and head weaving were not. On the other hand, pretreatment with morphine dose-dependently attenuated PCP-induced sniffing and head weaving, but not turning and backpedalling. These results suggest that PCP-induced stereotypy may be mediated by not only a sigma opioid receptor but also some other receptors. In addition, each component of PCP-induced stereotypy may be controlled by different opioid systems and/or neuronal systems.",

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10.1016/0091-3057(86)90497-1