Abstract
We investigated the effects of N-allylnormetazocine (SKF 10,047) and morphine on the stereotyped behaviors induced by the intraperitioneal injection of phencyclidine (PCP). PCP-induced turning and backpedalling were significantly potentiated by pretreatment with SKF 10,047 (10 mg/kg) but sniffing and head weaving were not. On the other hand, pretreatment with morphine dose-dependently attenuated PCP-induced sniffing and head weaving, but not turning and backpedalling. These results suggest that PCP-induced stereotypy may be mediated by not only a sigma opioid receptor but also some other receptors. In addition, each component of PCP-induced stereotypy may be controlled by different opioid systems and/or neuronal systems.
| Original language | English |
|---|---|
| Pages (from-to) | 1629-1634 |
| Number of pages | 6 |
| Journal | Pharmacology, Biochemistry and Behavior |
| Volume | 24 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 06-1986 |
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All Science Journal Classification (ASJC) codes
- Biochemistry
- Toxicology
- Pharmacology
- Clinical Biochemistry
- Biological Psychiatry
- Behavioral Neuroscience
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Phencyclidine-induced stereotyped behaviors after injection of morphine and N-allylnormetazocine (SKF 10,047) in rats. / Nabeshima, Toshitaka; Hiramatsu, Masayuki; Kameyama, Tsutomu.
In: Pharmacology, Biochemistry and Behavior, Vol. 24, No. 6, 06.1986, p. 1629-1634.Research output: Contribution to journal › Article
TY - JOUR
T1 - Phencyclidine-induced stereotyped behaviors after injection of morphine and N-allylnormetazocine (SKF 10,047) in rats
AU - Nabeshima, Toshitaka
AU - Hiramatsu, Masayuki
AU - Kameyama, Tsutomu
PY - 1986/6
Y1 - 1986/6
N2 - We investigated the effects of N-allylnormetazocine (SKF 10,047) and morphine on the stereotyped behaviors induced by the intraperitioneal injection of phencyclidine (PCP). PCP-induced turning and backpedalling were significantly potentiated by pretreatment with SKF 10,047 (10 mg/kg) but sniffing and head weaving were not. On the other hand, pretreatment with morphine dose-dependently attenuated PCP-induced sniffing and head weaving, but not turning and backpedalling. These results suggest that PCP-induced stereotypy may be mediated by not only a sigma opioid receptor but also some other receptors. In addition, each component of PCP-induced stereotypy may be controlled by different opioid systems and/or neuronal systems.
AB - We investigated the effects of N-allylnormetazocine (SKF 10,047) and morphine on the stereotyped behaviors induced by the intraperitioneal injection of phencyclidine (PCP). PCP-induced turning and backpedalling were significantly potentiated by pretreatment with SKF 10,047 (10 mg/kg) but sniffing and head weaving were not. On the other hand, pretreatment with morphine dose-dependently attenuated PCP-induced sniffing and head weaving, but not turning and backpedalling. These results suggest that PCP-induced stereotypy may be mediated by not only a sigma opioid receptor but also some other receptors. In addition, each component of PCP-induced stereotypy may be controlled by different opioid systems and/or neuronal systems.
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UR - http://www.scopus.com/inward/citedby.url?scp=0022482986&partnerID=8YFLogxK
U2 - 10.1016/0091-3057(86)90497-1
DO - 10.1016/0091-3057(86)90497-1
M3 - Article
C2 - 3016758
AN - SCOPUS:0022482986
VL - 24
SP - 1629
EP - 1634
JO - Pharmacology Biochemistry and Behavior
JF - Pharmacology Biochemistry and Behavior
SN - 0091-3057
IS - 6
ER -