Phencyclidine-induced stereotyped behaviors in rats following specific neurotoxin lesions of the striatum

Toshitaka Nabeshima, Kazumasa Yamaguchi, Kiyofumi Yamada, Masayuki Hiramatsu, Hiroshi Furukawa, Tsutomu Kameyama

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All the components of phencyclidine(PCP)-induced stereotyped behaviors, including sniffing, backpedalling, turning and head weaving were significantly decreased in rats following kainic acid lesion of the striatum. In the 6-hydroxydopamine lesioned rats, the behavioral score of PCP-induced stereotyped sniffing was similar to that in the sham-operated rats, while other components were significantly decreased. In addition, only the PCP-induced backpedalling and head weaving were significantly attenuated in the 5,6-dihydroxytryptamine lesioned rats. These results suggest that not only dopaminergic but also serotonergic and other systems in the striatum may play important roles in PCP-induced stereotyped behaviors.

Original languageEnglish
Pages (from-to)229-234
Number of pages6
JournalEuropean Journal of Pharmacology
Issue number3-4
Publication statusPublished - 30-09-1983


All Science Journal Classification (ASJC) codes

  • Pharmacology

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