Abstract
All the components of phencyclidine(PCP)-induced stereotyped behaviors, including sniffing, backpedalling, turning and head weaving were significantly decreased in rats following kainic acid lesion of the striatum. In the 6-hydroxydopamine lesioned rats, the behavioral score of PCP-induced stereotyped sniffing was similar to that in the sham-operated rats, while other components were significantly decreased. In addition, only the PCP-induced backpedalling and head weaving were significantly attenuated in the 5,6-dihydroxytryptamine lesioned rats. These results suggest that not only dopaminergic but also serotonergic and other systems in the striatum may play important roles in PCP-induced stereotyped behaviors.
| Original language | English |
|---|---|
| Pages (from-to) | 229-234 |
| Number of pages | 6 |
| Journal | European Journal of Pharmacology |
| Volume | 93 |
| Issue number | 3-4 |
| DOIs | |
| Publication status | Published - 30-09-1983 |
| Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Pharmacology
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