Phenotypic changes of AADC-only immunopositive premammillary neurons in the brain of laboratory shrew Suncus murinus by systemic administration of monoamine precursors

Nobuyuki Karasawa, Ryohachi Arai, Genzoh Isomura, Keiki Yamada, Kazuyoshi Sakai, Masao Sakai, Toshiharu Nagatsu, Ikuko Nagatsu

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

After 5-hydroxy-l-tryptophan (5-HTP) and l-3,4-dihydroxyphenylalanine (l-DOPA) were injected i.p. in the laboratory shrew Suncus murinus, immunocytochemical and immunofluorescence studies were conducted on continuous or same sections of the brain, using specific anti-tyrosine hydroxylase (TH), anti-aromatic l-amino acid decarboxylase (AADC), anti-dopamine (DA) and anti-serotonin (5-HT) antisera which were produced in our laboratory. The results of double-staining by the immunofluorescence method as well as immunoelectron microscopy strongly indicate that the cells of the premammillary nucleus of the laboratory shrew brain (AADC-only-positive neurons) are capable of synthesizing DA and 5-HT simultaneously upon simultaneous administration of l-DOPA and 5-HTP.

Original languageEnglish
Pages (from-to)65-70
Number of pages6
JournalNeuroscience Letters
Volume179
Issue number1-2
DOIs
Publication statusPublished - 26-09-1994

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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