Phenotypic expressions of type I, III, IV, V, and VI collagens in patients with diabetic nephropathy: Immunohistochemical comparison between HD and non-HD patients

Koji Kiryu, Yoshinari Tsuruta, Hiroyuki Morita, Yoshirou Fujita, Masaaki Kawasumi, Takahiro Shinzato, Shigeru Nakai, Kenji Maeda

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

Molecular organization of extracellular matrix (ECM) in the kidney may change as impairment of renal function progresses. The present immunohistochemical study of the kidney was designed to compare localization of type I, III, IV, V, and VI collagens between "Group A" (13 patients on maintenance hemodialysis due to diabetic nephropathy) and "Group B" (13 patients with diabetic nephropathy and massive proteinuria whose serum creatinine levels were 1.3 ± 0.5 mg/dl, mean ± SD). Nodular scleroses that were commonly observed both in Group A (87.8 ± 10.1%) and B (80.5 ± 17.0%) were stained in a very similar way with antibodies against collagen types IV, V, and VI. On the contrary, thickened Bowman's capsules that were observed exclusively in Group A (80.7 ± 10.4% in Group A versus 5.7 ± 6.2% in Group B) were stained intensely with antibodies against collagen types I and III. Normal and expanded peritubular interstitium from every group was stained with all of the above antibodies in an identical manner. Taken together, these results indicated a close relationship between severe impairment of residual renal function and a high incidence of thickened Bowman's capsule rich in type I and III collagens.

Original languageEnglish
Pages (from-to)365-373
Number of pages9
JournalJapanese Journal of Nephrology
Volume36
Issue number4
DOIs
Publication statusPublished - 1994
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Nephrology

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