Phosphorylation and Activation of Mitogen-Activated Protein Kinase by Kainic Acid-Induced Seizure in Rat Hippocampus

Y. S. Kim; K. S. Hong; Y. S. Seong; J. B. Park; S. Kuroda; K. Kishi; K. Kaibuchi; Y. Takai

doi:10.1006/bbrc.1994.2050

Phosphorylation and Activation of Mitogen-Activated Protein Kinase by Kainic Acid-Induced Seizure in Rat Hippocampus

Y. S. Kim, K. S. Hong, Y. S. Seong, J. B. Park, S. Kuroda, K. Kishi, K. Kaibuchi, Y. Takai

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Abstract

Injection of kainic acid into rat induced a limbic seizure and increased the activities of two protein kinases with Mrs of 42 kDa and 44 kDa in the hippocampus. These two protein kinases were identified as MAP kinases by an anti-MAP kinase antibody. These MAP kinases were phosphorylated at least at a tyrosine residue. The time course of the MAP kinase activation was roughly parallel with that of the seizure. These results indicate that the kainic acid-induced seizure induces MAP kinase activation in rat hippocampus.

Original language	English
Pages (from-to)	1163-1168
Number of pages	6
Journal	Biochemical and Biophysical Research Communications
Volume	202
Issue number	2
DOIs	https://doi.org/10.1006/bbrc.1994.2050
Publication status	Published - 29-07-1994
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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10.1006/bbrc.1994.2050

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abstract = "Injection of kainic acid into rat induced a limbic seizure and increased the activities of two protein kinases with Mrs of 42 kDa and 44 kDa in the hippocampus. These two protein kinases were identified as MAP kinases by an anti-MAP kinase antibody. These MAP kinases were phosphorylated at least at a tyrosine residue. The time course of the MAP kinase activation was roughly parallel with that of the seizure. These results indicate that the kainic acid-induced seizure induces MAP kinase activation in rat hippocampus.",

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AU - Hong, K. S.

AU - Seong, Y. S.

AU - Park, J. B.

AU - Kuroda, S.

AU - Kishi, K.

AU - Kaibuchi, K.

AU - Takai, Y.

PY - 1994/7/29

Y1 - 1994/7/29

N2 - Injection of kainic acid into rat induced a limbic seizure and increased the activities of two protein kinases with Mrs of 42 kDa and 44 kDa in the hippocampus. These two protein kinases were identified as MAP kinases by an anti-MAP kinase antibody. These MAP kinases were phosphorylated at least at a tyrosine residue. The time course of the MAP kinase activation was roughly parallel with that of the seizure. These results indicate that the kainic acid-induced seizure induces MAP kinase activation in rat hippocampus.

AB - Injection of kainic acid into rat induced a limbic seizure and increased the activities of two protein kinases with Mrs of 42 kDa and 44 kDa in the hippocampus. These two protein kinases were identified as MAP kinases by an anti-MAP kinase antibody. These MAP kinases were phosphorylated at least at a tyrosine residue. The time course of the MAP kinase activation was roughly parallel with that of the seizure. These results indicate that the kainic acid-induced seizure induces MAP kinase activation in rat hippocampus.

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Phosphorylation and Activation of Mitogen-Activated Protein Kinase by Kainic Acid-Induced Seizure in Rat Hippocampus

Abstract

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