TY - JOUR
T1 - Phosphorylation Signals Downstream of Dopamine Receptors in Emotional Behaviors
T2 - Association with Preference and Avoidance
AU - Zhang, Xinjian
AU - Tsuboi, Daisuke
AU - Funahashi, Yasuhiro
AU - Yamahashi, Yukie
AU - Kaibuchi, Kozo
AU - Nagai, Taku
N1 - Funding Information:
This work was supported by the following funding sources: ‘‘Bioinformatics for Brain Sciences’’ performed under the SRPBS from MEXT and AMED; AMED grant numbers: JP18dm0207005, 21mk0101156, JP21dm0207075, JP22wm0425017, and JP22wm0425008; JSPS KAKENHI grant numbers JP20K07082, 20H03428, JP21K06428, and JP21K06427; MEXT KAKENHI grant number JP21H00196; the Uehara Memorial Foundation; the Takeda Science Foundation; and a Grant-in-Aid from the Hori Sciences and Arts Foundation (FV2019); Smoking Research Foundation; Toyoaki Scholarship Foundation.
Publisher Copyright:
© 2022 by the authors.
PY - 2022/10
Y1 - 2022/10
N2 - Dopamine regulates emotional behaviors, including rewarding and aversive behaviors, through the mesolimbic dopaminergic pathway, which projects dopamine neurons from the ventral tegmental area to the nucleus accumbens (NAc). Protein phosphorylation is critical for intracellular signaling pathways and physiological functions, which are regulated by neurotransmitters in the brain. Previous studies have demonstrated that dopamine stimulated the phosphorylation of intracellular substrates, such as receptors, ion channels, and transcription factors, to regulate neuronal excitability and synaptic plasticity through dopamine receptors. We also established a novel database called KANPHOS that provides information on phosphorylation signals downstream of monoamines identified by our kinase substrate screening methods, including dopamine, in addition to those reported in the literature. Recent advances in proteomics techniques have enabled us to clarify the mechanisms through which dopamine controls rewarding and aversive behaviors through signal pathways in the NAc. In this review, we discuss the intracellular phosphorylation signals regulated by dopamine in these two emotional behaviors.
AB - Dopamine regulates emotional behaviors, including rewarding and aversive behaviors, through the mesolimbic dopaminergic pathway, which projects dopamine neurons from the ventral tegmental area to the nucleus accumbens (NAc). Protein phosphorylation is critical for intracellular signaling pathways and physiological functions, which are regulated by neurotransmitters in the brain. Previous studies have demonstrated that dopamine stimulated the phosphorylation of intracellular substrates, such as receptors, ion channels, and transcription factors, to regulate neuronal excitability and synaptic plasticity through dopamine receptors. We also established a novel database called KANPHOS that provides information on phosphorylation signals downstream of monoamines identified by our kinase substrate screening methods, including dopamine, in addition to those reported in the literature. Recent advances in proteomics techniques have enabled us to clarify the mechanisms through which dopamine controls rewarding and aversive behaviors through signal pathways in the NAc. In this review, we discuss the intracellular phosphorylation signals regulated by dopamine in these two emotional behaviors.
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U2 - 10.3390/ijms231911643
DO - 10.3390/ijms231911643
M3 - Review article
C2 - 36232945
AN - SCOPUS:85139996259
VL - 23
JO - International Journal of Molecular Sciences
JF - International Journal of Molecular Sciences
SN - 1661-6596
IS - 19
M1 - 11643
ER -