Phosphorylation Signals in Striatal Medium Spiny Neurons

Taku Nagai, Junichiro Yoshimoto, Takayuki Kannon, Keisuke Kuroda, Kozo Kaibuchi

Research output: Contribution to journalReview article

20 Citations (Scopus)

Abstract

Dopamine signaling in the brain is a complex phenomenon that strongly contributes to emotional behaviors. Medium spiny neurons (MSNs) play a major role in dopamine signaling through dopamine D1 receptors (D1Rs) or dopamine D2 receptors (D2Rs) in the striatum. cAMP/protein kinase A (PKA) regulates phosphorylation signals downstream of D1Rs, which affects the excitability of MSNs, leading to reward-associated emotional expression and memory formation. A combination of phosphoproteomic approaches and the curated KANPHOS database can be used to elucidate the physiological and pathophysiological functions of dopamine signaling and other monoamines. Emerging evidence from these techniques suggests that the Rap1 pathway plays a crucial role in the excitability of MSNs, leading to the expression of emotional behaviors.

Original languageEnglish
Pages (from-to)858-871
Number of pages14
JournalTrends in Pharmacological Sciences
Volume37
Issue number10
DOIs
Publication statusPublished - 01-10-2016

All Science Journal Classification (ASJC) codes

  • Toxicology
  • Pharmacology

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