TY - JOUR
T1 - Phosphorylation Signals in Striatal Medium Spiny Neurons
AU - Nagai, Taku
AU - Yoshimoto, Junichiro
AU - Kannon, Takayuki
AU - Kuroda, Keisuke
AU - Kaibuchi, Kozo
N1 - Funding Information:
This work was supported by the following funding sources: The Strategic Research Program for Brain Sciences from MEXT and AMED, the Brain Mapping by Integrated Neurotechnologies for Disease Studies (Brain/MINDS) from AMED, Grant-in-Aid for Scientific Research (A) (25251021) from MEXT, and Grant-in-Aid for Scientific Research on Innovative Areas (Comprehensive Brain Science Network) from MEXT.
Publisher Copyright:
© 2016 Elsevier Ltd
PY - 2016/10/1
Y1 - 2016/10/1
N2 - Dopamine signaling in the brain is a complex phenomenon that strongly contributes to emotional behaviors. Medium spiny neurons (MSNs) play a major role in dopamine signaling through dopamine D1 receptors (D1Rs) or dopamine D2 receptors (D2Rs) in the striatum. cAMP/protein kinase A (PKA) regulates phosphorylation signals downstream of D1Rs, which affects the excitability of MSNs, leading to reward-associated emotional expression and memory formation. A combination of phosphoproteomic approaches and the curated KANPHOS database can be used to elucidate the physiological and pathophysiological functions of dopamine signaling and other monoamines. Emerging evidence from these techniques suggests that the Rap1 pathway plays a crucial role in the excitability of MSNs, leading to the expression of emotional behaviors.
AB - Dopamine signaling in the brain is a complex phenomenon that strongly contributes to emotional behaviors. Medium spiny neurons (MSNs) play a major role in dopamine signaling through dopamine D1 receptors (D1Rs) or dopamine D2 receptors (D2Rs) in the striatum. cAMP/protein kinase A (PKA) regulates phosphorylation signals downstream of D1Rs, which affects the excitability of MSNs, leading to reward-associated emotional expression and memory formation. A combination of phosphoproteomic approaches and the curated KANPHOS database can be used to elucidate the physiological and pathophysiological functions of dopamine signaling and other monoamines. Emerging evidence from these techniques suggests that the Rap1 pathway plays a crucial role in the excitability of MSNs, leading to the expression of emotional behaviors.
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U2 - 10.1016/j.tips.2016.07.003
DO - 10.1016/j.tips.2016.07.003
M3 - Review article
C2 - 27546785
AN - SCOPUS:84987879356
VL - 37
SP - 858
EP - 871
JO - Trends in Pharmacological Sciences
JF - Trends in Pharmacological Sciences
SN - 0165-6147
IS - 10
ER -