Physical frailty in older people with severe aortic stenosis

Shogo Fukui, Michiyuki Kawakami, Yohei Otaka, Aiko Ishikawa, Katsuhiro Mizuno, Tetsuya Tsuji, Kentaro Hayashida, Taku Inohara, Fumiaki Yashima, Meigen Liu

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background: Assessment of physical frailty is important among elderly with severe aortic stenosis (AS) when considering treatment. Aims: We aimed to: (1) investigate the prevalence of physical frailty in older people with severe AS and (2) examine factors related to physical frailty. Methods: A total of 125 consecutive elderly AS patients (mean age 84.6 ± 4.4 year) were enrolled. Physical frailty was defined as scoring ≤8 points on the short physical performance battery (SPPB). Factors likely related to physical frailty, including cardiac function, nutritional and metabolic status, kidney function, medical history, and comorbidities, were evaluated. Logistic regression analyses were used to examine which factors were related to physical frailty. Results: Physical frailty was prevalent in 38.4 %. After sex and age adjusted, the following were significantly related to physical frailty: LVEF (adjusted OR per 10 % decrease: 1.39, p < 0.05), the Mini Nutritional Assessment-Short Form (adjusted OR per 1 point decrease: 1.21, p < 0.05), serum albumin (adjusted OR per 1 g/dL decrease: 2.64, p < 0.05), HDL-C (adjusted OR per 10 mg/dL decrease: 1.52, p < 0.01), eGFR (adjusted OR per 10 mL/min decrease: 1.59, p < 0.05), grip strength (adjusted OR per 10 kg decrease: 3.60, p < 0.01), coronary heart disease (adjusted OR: 2.78, p < 0.01), cerebrovascular disease (adjusted OR: 6.06, p < 0.01), and musculoskeletal disorders (adjusted OR: 3.28, p < 0.01). Conclusions: The prevalence of physical frailty is high and related to nutritional status, comorbidities, and cardiac status.

Original languageEnglish
Pages (from-to)1081-1087
Number of pages7
JournalAging Clinical and Experimental Research
Volume28
Issue number6
DOIs
Publication statusPublished - 01-12-2016

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Aortic Valve Stenosis
Nutritional Status
Comorbidity
Cerebrovascular Disorders
Nutrition Assessment
Hand Strength
Serum Albumin
Coronary Disease
Logistic Models
Regression Analysis
Kidney
Therapeutics

All Science Journal Classification (ASJC) codes

  • Ageing
  • Geriatrics and Gerontology

Cite this

Fukui, S., Kawakami, M., Otaka, Y., Ishikawa, A., Mizuno, K., Tsuji, T., ... Liu, M. (2016). Physical frailty in older people with severe aortic stenosis. Aging Clinical and Experimental Research, 28(6), 1081-1087. https://doi.org/10.1007/s40520-015-0507-0
Fukui, Shogo ; Kawakami, Michiyuki ; Otaka, Yohei ; Ishikawa, Aiko ; Mizuno, Katsuhiro ; Tsuji, Tetsuya ; Hayashida, Kentaro ; Inohara, Taku ; Yashima, Fumiaki ; Liu, Meigen. / Physical frailty in older people with severe aortic stenosis. In: Aging Clinical and Experimental Research. 2016 ; Vol. 28, No. 6. pp. 1081-1087.
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abstract = "Background: Assessment of physical frailty is important among elderly with severe aortic stenosis (AS) when considering treatment. Aims: We aimed to: (1) investigate the prevalence of physical frailty in older people with severe AS and (2) examine factors related to physical frailty. Methods: A total of 125 consecutive elderly AS patients (mean age 84.6 ± 4.4 year) were enrolled. Physical frailty was defined as scoring ≤8 points on the short physical performance battery (SPPB). Factors likely related to physical frailty, including cardiac function, nutritional and metabolic status, kidney function, medical history, and comorbidities, were evaluated. Logistic regression analyses were used to examine which factors were related to physical frailty. Results: Physical frailty was prevalent in 38.4 {\%}. After sex and age adjusted, the following were significantly related to physical frailty: LVEF (adjusted OR per 10 {\%} decrease: 1.39, p < 0.05), the Mini Nutritional Assessment-Short Form (adjusted OR per 1 point decrease: 1.21, p < 0.05), serum albumin (adjusted OR per 1 g/dL decrease: 2.64, p < 0.05), HDL-C (adjusted OR per 10 mg/dL decrease: 1.52, p < 0.01), eGFR (adjusted OR per 10 mL/min decrease: 1.59, p < 0.05), grip strength (adjusted OR per 10 kg decrease: 3.60, p < 0.01), coronary heart disease (adjusted OR: 2.78, p < 0.01), cerebrovascular disease (adjusted OR: 6.06, p < 0.01), and musculoskeletal disorders (adjusted OR: 3.28, p < 0.01). Conclusions: The prevalence of physical frailty is high and related to nutritional status, comorbidities, and cardiac status.",
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Fukui, S, Kawakami, M, Otaka, Y, Ishikawa, A, Mizuno, K, Tsuji, T, Hayashida, K, Inohara, T, Yashima, F & Liu, M 2016, 'Physical frailty in older people with severe aortic stenosis', Aging Clinical and Experimental Research, vol. 28, no. 6, pp. 1081-1087. https://doi.org/10.1007/s40520-015-0507-0

Physical frailty in older people with severe aortic stenosis. / Fukui, Shogo; Kawakami, Michiyuki; Otaka, Yohei; Ishikawa, Aiko; Mizuno, Katsuhiro; Tsuji, Tetsuya; Hayashida, Kentaro; Inohara, Taku; Yashima, Fumiaki; Liu, Meigen.

In: Aging Clinical and Experimental Research, Vol. 28, No. 6, 01.12.2016, p. 1081-1087.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Physical frailty in older people with severe aortic stenosis

AU - Fukui, Shogo

AU - Kawakami, Michiyuki

AU - Otaka, Yohei

AU - Ishikawa, Aiko

AU - Mizuno, Katsuhiro

AU - Tsuji, Tetsuya

AU - Hayashida, Kentaro

AU - Inohara, Taku

AU - Yashima, Fumiaki

AU - Liu, Meigen

PY - 2016/12/1

Y1 - 2016/12/1

N2 - Background: Assessment of physical frailty is important among elderly with severe aortic stenosis (AS) when considering treatment. Aims: We aimed to: (1) investigate the prevalence of physical frailty in older people with severe AS and (2) examine factors related to physical frailty. Methods: A total of 125 consecutive elderly AS patients (mean age 84.6 ± 4.4 year) were enrolled. Physical frailty was defined as scoring ≤8 points on the short physical performance battery (SPPB). Factors likely related to physical frailty, including cardiac function, nutritional and metabolic status, kidney function, medical history, and comorbidities, were evaluated. Logistic regression analyses were used to examine which factors were related to physical frailty. Results: Physical frailty was prevalent in 38.4 %. After sex and age adjusted, the following were significantly related to physical frailty: LVEF (adjusted OR per 10 % decrease: 1.39, p < 0.05), the Mini Nutritional Assessment-Short Form (adjusted OR per 1 point decrease: 1.21, p < 0.05), serum albumin (adjusted OR per 1 g/dL decrease: 2.64, p < 0.05), HDL-C (adjusted OR per 10 mg/dL decrease: 1.52, p < 0.01), eGFR (adjusted OR per 10 mL/min decrease: 1.59, p < 0.05), grip strength (adjusted OR per 10 kg decrease: 3.60, p < 0.01), coronary heart disease (adjusted OR: 2.78, p < 0.01), cerebrovascular disease (adjusted OR: 6.06, p < 0.01), and musculoskeletal disorders (adjusted OR: 3.28, p < 0.01). Conclusions: The prevalence of physical frailty is high and related to nutritional status, comorbidities, and cardiac status.

AB - Background: Assessment of physical frailty is important among elderly with severe aortic stenosis (AS) when considering treatment. Aims: We aimed to: (1) investigate the prevalence of physical frailty in older people with severe AS and (2) examine factors related to physical frailty. Methods: A total of 125 consecutive elderly AS patients (mean age 84.6 ± 4.4 year) were enrolled. Physical frailty was defined as scoring ≤8 points on the short physical performance battery (SPPB). Factors likely related to physical frailty, including cardiac function, nutritional and metabolic status, kidney function, medical history, and comorbidities, were evaluated. Logistic regression analyses were used to examine which factors were related to physical frailty. Results: Physical frailty was prevalent in 38.4 %. After sex and age adjusted, the following were significantly related to physical frailty: LVEF (adjusted OR per 10 % decrease: 1.39, p < 0.05), the Mini Nutritional Assessment-Short Form (adjusted OR per 1 point decrease: 1.21, p < 0.05), serum albumin (adjusted OR per 1 g/dL decrease: 2.64, p < 0.05), HDL-C (adjusted OR per 10 mg/dL decrease: 1.52, p < 0.01), eGFR (adjusted OR per 10 mL/min decrease: 1.59, p < 0.05), grip strength (adjusted OR per 10 kg decrease: 3.60, p < 0.01), coronary heart disease (adjusted OR: 2.78, p < 0.01), cerebrovascular disease (adjusted OR: 6.06, p < 0.01), and musculoskeletal disorders (adjusted OR: 3.28, p < 0.01). Conclusions: The prevalence of physical frailty is high and related to nutritional status, comorbidities, and cardiac status.

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