Pilot study of probe-based confocal laser endomicroscopy with fluorescein-dripping method for liver tumors

Masaki Morimoto, Soichiro Honjo, Teruhisa Sakamoto, Ei Uchinaka, Masataka Amisaki, Yosuke Arai, Manabu Yamamoto, Yoji Fukumoto, Tomohiro Osaki, Naruo Tokuyasu, Keigo Ashida, Hiroaki Saito, Yoshiyuki Fujiwara

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Background/Aim: Probe-based confocal laser endomicroscopy (pCLE) is a novel diagnostic technique that can provide real-time imaging of tissues at the cellular level. In this study, pCLE was applied to liver tumors and its diagnostic value was evaluated. Patients and Methods: Ten patients who underwent hepatectomy for liver tumors were evaluated with pCLE from February to May 2017. Immediately after liver resection, pCLE evaluation was performed in the operating room as an ex vivo study. The newly-adopted "fluorescein-dripping method" was used for the observation. Results: First, the optimal fluorescein exposure time for the surface of liver was defined in the fluorescein-dripping method. Next, the distinctive findings in the cancerous region were investigated. The characteristic appearance of irregular arrangements of concentrated cells under fluorescein dripping was observed in six of seven hepatocellular carcinoma (HCC) tumors. Conclusion: In all HCC specimens, discrimination of the cancerous region from normal liver was possible with pCLE.

Original languageEnglish
Pages (from-to)4775-4781
Number of pages7
JournalAnticancer research
Volume38
Issue number8
DOIs
Publication statusPublished - 08-2018
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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