TY - JOUR
T1 - Pineoblastoma with neuronal differentiation — Immunohistochemical and immunocytochemical studies
AU - Okuda, Yasuhiro
AU - Taomoto, Katsushi
AU - Saya, Hideyuki
AU - Ijichi, Akihiro
AU - Kokunai, Takashi
AU - Tamaki, Norihiko
AU - Matsumoto, Satoshi
PY - 1988/6
Y1 - 1988/6
N2 - Immunohistochemical and immunocytochemical studies were performed on a specimen obtained at operation from a 4 year-old female with intracranially spread pineal tumor in the right temporal lobe. Microscopically, it was a highly cellular tumor, and the cells contained chromatin-rich round or oval nuclei and scanty cytoplasms. There were numerous mitotic figures. Rossetes were not detected. Both immunohistochemical staining of paraffin-embedded sections and immunocytochemical staining of short-term cultured cells disclosed a subgroups of cell positive for NSE and 68K-NF (neurofilament). No cells were positive for GFAP, S-100 protein or HCG. From these findings, the tumor was thought to be pineoblastoma, which is an undifferentiated tumor that rarely shows divergent differentiating potential. This is the first report of pineoblastoma with the differentiation only toward the neuronal line confirmed by the analysis of immunohistochemistry and immunocytochemistry.
AB - Immunohistochemical and immunocytochemical studies were performed on a specimen obtained at operation from a 4 year-old female with intracranially spread pineal tumor in the right temporal lobe. Microscopically, it was a highly cellular tumor, and the cells contained chromatin-rich round or oval nuclei and scanty cytoplasms. There were numerous mitotic figures. Rossetes were not detected. Both immunohistochemical staining of paraffin-embedded sections and immunocytochemical staining of short-term cultured cells disclosed a subgroups of cell positive for NSE and 68K-NF (neurofilament). No cells were positive for GFAP, S-100 protein or HCG. From these findings, the tumor was thought to be pineoblastoma, which is an undifferentiated tumor that rarely shows divergent differentiating potential. This is the first report of pineoblastoma with the differentiation only toward the neuronal line confirmed by the analysis of immunohistochemistry and immunocytochemistry.
KW - cell differentiation
KW - immunocytochemistry
KW - immunohistochemistry
KW - neurofilament
KW - pineoblastoma
KW - primitive neuroectodermal tumor
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U2 - 10.1007/BF02327396
DO - 10.1007/BF02327396
M3 - Article
C2 - 3066852
AN - SCOPUS:0023764976
SN - 0167-594X
VL - 6
SP - 193
EP - 198
JO - Journal of Neuro-Oncology
JF - Journal of Neuro-Oncology
IS - 2
ER -