Placental pathology in Plasmodium berghei-infected rats

T. Tegoshi, R. S. Desowitz, K. G. Pirl, Y. Maeno, M. Aikawa

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

The pathologic changes in placentae of pregnant rats infected with Plasmodium berghei at different stages of gestation were studied using light and electron microscopy and immunohistochemistry. The major changes observed were thickening and duplication of the trophoblastic basement membrane, and accumulation of parasitized erythrocytes and occasional mononuclear cells in the maternal blood space. Immunohistochemical examination of nine placentae revealed that six stained positively for IgG, two for IgM, and four for P. berghei antigen. No C3 deposition was detected. The findings in this study indicate that the variable parasitologic-clinical course from benign to fatal of P. berghei infection in pregnant rats makes it a potentially valuable model of human gestational malaria infection.

Original languageEnglish
Pages (from-to)643-651
Number of pages9
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume47
Issue number5
DOIs
Publication statusPublished - 01-01-1992

Fingerprint

Plasmodium berghei
Pathology
Placenta
Malaria
Basement Membrane
Immunoglobulin M
Electron Microscopy
Immunoglobulin G
Erythrocytes
Immunohistochemistry
Mothers
Light
Antigens
Pregnancy
Infection

All Science Journal Classification (ASJC) codes

  • Parasitology
  • Infectious Diseases
  • Virology

Cite this

Tegoshi, T. ; Desowitz, R. S. ; Pirl, K. G. ; Maeno, Y. ; Aikawa, M. / Placental pathology in Plasmodium berghei-infected rats. In: American Journal of Tropical Medicine and Hygiene. 1992 ; Vol. 47, No. 5. pp. 643-651.
@article{7bb4e8f5565943e09f8a04f9efb801a7,
title = "Placental pathology in Plasmodium berghei-infected rats",
abstract = "The pathologic changes in placentae of pregnant rats infected with Plasmodium berghei at different stages of gestation were studied using light and electron microscopy and immunohistochemistry. The major changes observed were thickening and duplication of the trophoblastic basement membrane, and accumulation of parasitized erythrocytes and occasional mononuclear cells in the maternal blood space. Immunohistochemical examination of nine placentae revealed that six stained positively for IgG, two for IgM, and four for P. berghei antigen. No C3 deposition was detected. The findings in this study indicate that the variable parasitologic-clinical course from benign to fatal of P. berghei infection in pregnant rats makes it a potentially valuable model of human gestational malaria infection.",
author = "T. Tegoshi and Desowitz, {R. S.} and Pirl, {K. G.} and Y. Maeno and M. Aikawa",
year = "1992",
month = "1",
day = "1",
doi = "10.4269/ajtmh.1992.47.643",
language = "English",
volume = "47",
pages = "643--651",
journal = "American Journal of Tropical Medicine and Hygiene",
issn = "0002-9637",
publisher = "American Society of Tropical Medicine and Hygiene",
number = "5",

}

Placental pathology in Plasmodium berghei-infected rats. / Tegoshi, T.; Desowitz, R. S.; Pirl, K. G.; Maeno, Y.; Aikawa, M.

In: American Journal of Tropical Medicine and Hygiene, Vol. 47, No. 5, 01.01.1992, p. 643-651.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Placental pathology in Plasmodium berghei-infected rats

AU - Tegoshi, T.

AU - Desowitz, R. S.

AU - Pirl, K. G.

AU - Maeno, Y.

AU - Aikawa, M.

PY - 1992/1/1

Y1 - 1992/1/1

N2 - The pathologic changes in placentae of pregnant rats infected with Plasmodium berghei at different stages of gestation were studied using light and electron microscopy and immunohistochemistry. The major changes observed were thickening and duplication of the trophoblastic basement membrane, and accumulation of parasitized erythrocytes and occasional mononuclear cells in the maternal blood space. Immunohistochemical examination of nine placentae revealed that six stained positively for IgG, two for IgM, and four for P. berghei antigen. No C3 deposition was detected. The findings in this study indicate that the variable parasitologic-clinical course from benign to fatal of P. berghei infection in pregnant rats makes it a potentially valuable model of human gestational malaria infection.

AB - The pathologic changes in placentae of pregnant rats infected with Plasmodium berghei at different stages of gestation were studied using light and electron microscopy and immunohistochemistry. The major changes observed were thickening and duplication of the trophoblastic basement membrane, and accumulation of parasitized erythrocytes and occasional mononuclear cells in the maternal blood space. Immunohistochemical examination of nine placentae revealed that six stained positively for IgG, two for IgM, and four for P. berghei antigen. No C3 deposition was detected. The findings in this study indicate that the variable parasitologic-clinical course from benign to fatal of P. berghei infection in pregnant rats makes it a potentially valuable model of human gestational malaria infection.

UR - http://www.scopus.com/inward/record.url?scp=0026492773&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026492773&partnerID=8YFLogxK

U2 - 10.4269/ajtmh.1992.47.643

DO - 10.4269/ajtmh.1992.47.643

M3 - Article

VL - 47

SP - 643

EP - 651

JO - American Journal of Tropical Medicine and Hygiene

JF - American Journal of Tropical Medicine and Hygiene

SN - 0002-9637

IS - 5

ER -