Plasma concentration of brain natriuretic peptide as a biochemical marker for the evaluation of right ventricular overload and mortality in chronic respiratory disease

Junichi Ishii, Masanori Nomura, Mikiya Ito, Hiroyuki Naruse, Yoshihisa Mori, Jian hua Wang, Takashi Ishikawa, Hiroshi Kurokawa, Takeshi Kondo, Youichi Nagamura, Kouzi Ezaki, Yoshihiko Watanabe, Hitoshi Hishida

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Abstract

The purpose of this study was to evaluate whether the plasma brain natriuretic peptide (BNP) concentration is a useful marker of right ventricular (RV) overload and whether it has prognostic value as a predictor of death in patients with chronic respiratory disease (CRD). We measured the plasma BNP and atrial natriuretic peptide (ANP) concentrations in 31 consecutive patients with CRD who underwent right-heart catheterization to evaluate pulmonary hypertension. All patients were followed for >12 months. The plasma BNP concentration closely correlated with the mean pulmonary artery pressure and pulmonary vascular resistance (r = 0.62, P < 0.0005 and r = 0.85, P < 0.0001), and showed a weak linear correlation with cardiac output (r = -0.36, P < 0.05). During the follow-up period, 5 (16%) end-stage CRD deaths (4 RV heart failure and 1 respiratory infection) and 2 non-end-stage CRD deaths occurred. In a stepwise multivariate Cox proportional-hazards regression analysis including age, sex, BNP, ANP, hemodynamic variables and the ratio of PaO2 to fraction of inspired oxygen, only BNP (P < 0.05) was an independent predictor of end-stage CRD death. The upward and leftward shift in the receiver operating characteristic curve between patients with end- stage CRD death and those without was greater for BNP than for ANP. Our findings suggest that the plasma BNP concentration may be an inexpensive, simple and useful marker of RV overload and end-stage CRD death in CRD patients. These preliminary results need to be confirmed in a large series of CRD patients. (C) 2000 Elsevier Science B.V.

Original languageEnglish
Pages (from-to)19-30
Number of pages12
JournalClinica Chimica Acta
Volume301
Issue number1-2
DOIs
Publication statusPublished - 01-11-2000

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Pulmonary diseases
Brain Natriuretic Peptide
Chronic Disease
Biomarkers
Plasmas
Mortality
Atrial Natriuretic Factor
Hemodynamics
Cardiac Catheterization
Pulmonary Hypertension
Regression analysis
ROC Curve
Respiratory Tract Infections
Cardiac Output
Vascular Resistance
Pulmonary Artery
Hazards
Heart Failure
Regression Analysis
Oxygen

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Ishii, Junichi ; Nomura, Masanori ; Ito, Mikiya ; Naruse, Hiroyuki ; Mori, Yoshihisa ; Wang, Jian hua ; Ishikawa, Takashi ; Kurokawa, Hiroshi ; Kondo, Takeshi ; Nagamura, Youichi ; Ezaki, Kouzi ; Watanabe, Yoshihiko ; Hishida, Hitoshi. / Plasma concentration of brain natriuretic peptide as a biochemical marker for the evaluation of right ventricular overload and mortality in chronic respiratory disease. In: Clinica Chimica Acta. 2000 ; Vol. 301, No. 1-2. pp. 19-30.
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abstract = "The purpose of this study was to evaluate whether the plasma brain natriuretic peptide (BNP) concentration is a useful marker of right ventricular (RV) overload and whether it has prognostic value as a predictor of death in patients with chronic respiratory disease (CRD). We measured the plasma BNP and atrial natriuretic peptide (ANP) concentrations in 31 consecutive patients with CRD who underwent right-heart catheterization to evaluate pulmonary hypertension. All patients were followed for >12 months. The plasma BNP concentration closely correlated with the mean pulmonary artery pressure and pulmonary vascular resistance (r = 0.62, P < 0.0005 and r = 0.85, P < 0.0001), and showed a weak linear correlation with cardiac output (r = -0.36, P < 0.05). During the follow-up period, 5 (16{\%}) end-stage CRD deaths (4 RV heart failure and 1 respiratory infection) and 2 non-end-stage CRD deaths occurred. In a stepwise multivariate Cox proportional-hazards regression analysis including age, sex, BNP, ANP, hemodynamic variables and the ratio of PaO2 to fraction of inspired oxygen, only BNP (P < 0.05) was an independent predictor of end-stage CRD death. The upward and leftward shift in the receiver operating characteristic curve between patients with end- stage CRD death and those without was greater for BNP than for ANP. Our findings suggest that the plasma BNP concentration may be an inexpensive, simple and useful marker of RV overload and end-stage CRD death in CRD patients. These preliminary results need to be confirmed in a large series of CRD patients. (C) 2000 Elsevier Science B.V.",
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Ishii, J, Nomura, M, Ito, M, Naruse, H, Mori, Y, Wang, JH, Ishikawa, T, Kurokawa, H, Kondo, T, Nagamura, Y, Ezaki, K, Watanabe, Y & Hishida, H 2000, 'Plasma concentration of brain natriuretic peptide as a biochemical marker for the evaluation of right ventricular overload and mortality in chronic respiratory disease', Clinica Chimica Acta, vol. 301, no. 1-2, pp. 19-30. https://doi.org/10.1016/S0009-8981(00)00312-0

Plasma concentration of brain natriuretic peptide as a biochemical marker for the evaluation of right ventricular overload and mortality in chronic respiratory disease. / Ishii, Junichi; Nomura, Masanori; Ito, Mikiya; Naruse, Hiroyuki; Mori, Yoshihisa; Wang, Jian hua; Ishikawa, Takashi; Kurokawa, Hiroshi; Kondo, Takeshi; Nagamura, Youichi; Ezaki, Kouzi; Watanabe, Yoshihiko; Hishida, Hitoshi.

In: Clinica Chimica Acta, Vol. 301, No. 1-2, 01.11.2000, p. 19-30.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Plasma concentration of brain natriuretic peptide as a biochemical marker for the evaluation of right ventricular overload and mortality in chronic respiratory disease

AU - Ishii, Junichi

AU - Nomura, Masanori

AU - Ito, Mikiya

AU - Naruse, Hiroyuki

AU - Mori, Yoshihisa

AU - Wang, Jian hua

AU - Ishikawa, Takashi

AU - Kurokawa, Hiroshi

AU - Kondo, Takeshi

AU - Nagamura, Youichi

AU - Ezaki, Kouzi

AU - Watanabe, Yoshihiko

AU - Hishida, Hitoshi

PY - 2000/11/1

Y1 - 2000/11/1

N2 - The purpose of this study was to evaluate whether the plasma brain natriuretic peptide (BNP) concentration is a useful marker of right ventricular (RV) overload and whether it has prognostic value as a predictor of death in patients with chronic respiratory disease (CRD). We measured the plasma BNP and atrial natriuretic peptide (ANP) concentrations in 31 consecutive patients with CRD who underwent right-heart catheterization to evaluate pulmonary hypertension. All patients were followed for >12 months. The plasma BNP concentration closely correlated with the mean pulmonary artery pressure and pulmonary vascular resistance (r = 0.62, P < 0.0005 and r = 0.85, P < 0.0001), and showed a weak linear correlation with cardiac output (r = -0.36, P < 0.05). During the follow-up period, 5 (16%) end-stage CRD deaths (4 RV heart failure and 1 respiratory infection) and 2 non-end-stage CRD deaths occurred. In a stepwise multivariate Cox proportional-hazards regression analysis including age, sex, BNP, ANP, hemodynamic variables and the ratio of PaO2 to fraction of inspired oxygen, only BNP (P < 0.05) was an independent predictor of end-stage CRD death. The upward and leftward shift in the receiver operating characteristic curve between patients with end- stage CRD death and those without was greater for BNP than for ANP. Our findings suggest that the plasma BNP concentration may be an inexpensive, simple and useful marker of RV overload and end-stage CRD death in CRD patients. These preliminary results need to be confirmed in a large series of CRD patients. (C) 2000 Elsevier Science B.V.

AB - The purpose of this study was to evaluate whether the plasma brain natriuretic peptide (BNP) concentration is a useful marker of right ventricular (RV) overload and whether it has prognostic value as a predictor of death in patients with chronic respiratory disease (CRD). We measured the plasma BNP and atrial natriuretic peptide (ANP) concentrations in 31 consecutive patients with CRD who underwent right-heart catheterization to evaluate pulmonary hypertension. All patients were followed for >12 months. The plasma BNP concentration closely correlated with the mean pulmonary artery pressure and pulmonary vascular resistance (r = 0.62, P < 0.0005 and r = 0.85, P < 0.0001), and showed a weak linear correlation with cardiac output (r = -0.36, P < 0.05). During the follow-up period, 5 (16%) end-stage CRD deaths (4 RV heart failure and 1 respiratory infection) and 2 non-end-stage CRD deaths occurred. In a stepwise multivariate Cox proportional-hazards regression analysis including age, sex, BNP, ANP, hemodynamic variables and the ratio of PaO2 to fraction of inspired oxygen, only BNP (P < 0.05) was an independent predictor of end-stage CRD death. The upward and leftward shift in the receiver operating characteristic curve between patients with end- stage CRD death and those without was greater for BNP than for ANP. Our findings suggest that the plasma BNP concentration may be an inexpensive, simple and useful marker of RV overload and end-stage CRD death in CRD patients. These preliminary results need to be confirmed in a large series of CRD patients. (C) 2000 Elsevier Science B.V.

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