Plasma homocyst(e)ine concentrations and the risk of subtypes of cerebral infarction: The Hisayama study

Haruki Shimizu, Yutaka Kiyohara, Isao Kato, Yumihiro Tanizaki, Hirofumi Ueno, Yasuhiro Kimura, Hiromitsu Iwamoto, Michiaki Kubo, Hisatomi Arima, Setsuro Ibayashi, Masatoshi Fujishima

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Abstract

Moderately elevated plasma total homocyst(e)ine (tHcy) levels have been linked with cardiovascular disease. However, the findings of previous studies regarding the relationship between tHcy levels and subtypes of cerebral infarction (CI) have been conflicting. The aim of the present study was to examine this issue in a community-based case-control study performed in Hisayama Town in Japan. Fasting tHcy levels were compared among 75 CI cases, of which 43 were lacunar (LI), 24 atherothrombotic (ATI) and 8 cardioembolic infarctions (CEI), and 248 age- and sex-matched healthy controls. The mean tHcy concentrations were higher in CI than in controls (13.0 vs. 11.8 μmol/l; p = 0.018). LI and CEI also had significantly higher tHcy levels than did the corresponding controls (12.3 vs. 11.3 μmol/l for LI; p = 0.037 and 16.3 vs. 12.7 μmol/l for CEI; p = 0.036). The same tendency was also observed for ATI, but the difference was only marginally significant probably due to the small number of the cases (13.4 vs. 11.9 μmol/l; p = 0.087). After adjustment for age, sex, hypertension, serum creatinine, total protein, folate and vitamin B12 levels, the risk of LI was not significant in the second tertile of the tHcy distribution, but significantly increased in the third compared with the first tertile (adjusted odds ratio, AOR, 3.4; 95% confidence limits, CL, 1.3-8.9; p = 0.015), while the risk of ATI was significant even in the second tertile (AOR, 5.0; 95% CL, 1.0-23.7; p = 0.042) and higher in the third tertile (AOR, 7.5; 95% CL, 1.5-38.3; p = 0.015). However, the odds ratios for CEI could not be estimated, as there was no case of CEI in the first tertile. These findings suggest that elevated tHcy is an independent risk factor for all subtypes of CI, but that its impact is higher in ATI and probably in CEI than in LI.

Original languageEnglish
Pages (from-to)9-15
Number of pages7
JournalCerebrovascular Diseases
Volume13
Issue number1
DOIs
Publication statusPublished - 14-02-2002

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Cerebral Infarction
Infarction
Odds Ratio
Vitamin B 12
Folic Acid
Case-Control Studies
Fasting
Creatinine
Japan
Cardiovascular Diseases
Hypertension
Serum
Proteins

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

Cite this

Shimizu, H., Kiyohara, Y., Kato, I., Tanizaki, Y., Ueno, H., Kimura, Y., ... Fujishima, M. (2002). Plasma homocyst(e)ine concentrations and the risk of subtypes of cerebral infarction: The Hisayama study. Cerebrovascular Diseases, 13(1), 9-15. https://doi.org/10.1159/000047739
Shimizu, Haruki ; Kiyohara, Yutaka ; Kato, Isao ; Tanizaki, Yumihiro ; Ueno, Hirofumi ; Kimura, Yasuhiro ; Iwamoto, Hiromitsu ; Kubo, Michiaki ; Arima, Hisatomi ; Ibayashi, Setsuro ; Fujishima, Masatoshi. / Plasma homocyst(e)ine concentrations and the risk of subtypes of cerebral infarction : The Hisayama study. In: Cerebrovascular Diseases. 2002 ; Vol. 13, No. 1. pp. 9-15.
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abstract = "Moderately elevated plasma total homocyst(e)ine (tHcy) levels have been linked with cardiovascular disease. However, the findings of previous studies regarding the relationship between tHcy levels and subtypes of cerebral infarction (CI) have been conflicting. The aim of the present study was to examine this issue in a community-based case-control study performed in Hisayama Town in Japan. Fasting tHcy levels were compared among 75 CI cases, of which 43 were lacunar (LI), 24 atherothrombotic (ATI) and 8 cardioembolic infarctions (CEI), and 248 age- and sex-matched healthy controls. The mean tHcy concentrations were higher in CI than in controls (13.0 vs. 11.8 μmol/l; p = 0.018). LI and CEI also had significantly higher tHcy levels than did the corresponding controls (12.3 vs. 11.3 μmol/l for LI; p = 0.037 and 16.3 vs. 12.7 μmol/l for CEI; p = 0.036). The same tendency was also observed for ATI, but the difference was only marginally significant probably due to the small number of the cases (13.4 vs. 11.9 μmol/l; p = 0.087). After adjustment for age, sex, hypertension, serum creatinine, total protein, folate and vitamin B12 levels, the risk of LI was not significant in the second tertile of the tHcy distribution, but significantly increased in the third compared with the first tertile (adjusted odds ratio, AOR, 3.4; 95{\%} confidence limits, CL, 1.3-8.9; p = 0.015), while the risk of ATI was significant even in the second tertile (AOR, 5.0; 95{\%} CL, 1.0-23.7; p = 0.042) and higher in the third tertile (AOR, 7.5; 95{\%} CL, 1.5-38.3; p = 0.015). However, the odds ratios for CEI could not be estimated, as there was no case of CEI in the first tertile. These findings suggest that elevated tHcy is an independent risk factor for all subtypes of CI, but that its impact is higher in ATI and probably in CEI than in LI.",
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Shimizu, H, Kiyohara, Y, Kato, I, Tanizaki, Y, Ueno, H, Kimura, Y, Iwamoto, H, Kubo, M, Arima, H, Ibayashi, S & Fujishima, M 2002, 'Plasma homocyst(e)ine concentrations and the risk of subtypes of cerebral infarction: The Hisayama study', Cerebrovascular Diseases, vol. 13, no. 1, pp. 9-15. https://doi.org/10.1159/000047739

Plasma homocyst(e)ine concentrations and the risk of subtypes of cerebral infarction : The Hisayama study. / Shimizu, Haruki; Kiyohara, Yutaka; Kato, Isao; Tanizaki, Yumihiro; Ueno, Hirofumi; Kimura, Yasuhiro; Iwamoto, Hiromitsu; Kubo, Michiaki; Arima, Hisatomi; Ibayashi, Setsuro; Fujishima, Masatoshi.

In: Cerebrovascular Diseases, Vol. 13, No. 1, 14.02.2002, p. 9-15.

Research output: Contribution to journalArticle

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T1 - Plasma homocyst(e)ine concentrations and the risk of subtypes of cerebral infarction

T2 - The Hisayama study

AU - Shimizu, Haruki

AU - Kiyohara, Yutaka

AU - Kato, Isao

AU - Tanizaki, Yumihiro

AU - Ueno, Hirofumi

AU - Kimura, Yasuhiro

AU - Iwamoto, Hiromitsu

AU - Kubo, Michiaki

AU - Arima, Hisatomi

AU - Ibayashi, Setsuro

AU - Fujishima, Masatoshi

PY - 2002/2/14

Y1 - 2002/2/14

N2 - Moderately elevated plasma total homocyst(e)ine (tHcy) levels have been linked with cardiovascular disease. However, the findings of previous studies regarding the relationship between tHcy levels and subtypes of cerebral infarction (CI) have been conflicting. The aim of the present study was to examine this issue in a community-based case-control study performed in Hisayama Town in Japan. Fasting tHcy levels were compared among 75 CI cases, of which 43 were lacunar (LI), 24 atherothrombotic (ATI) and 8 cardioembolic infarctions (CEI), and 248 age- and sex-matched healthy controls. The mean tHcy concentrations were higher in CI than in controls (13.0 vs. 11.8 μmol/l; p = 0.018). LI and CEI also had significantly higher tHcy levels than did the corresponding controls (12.3 vs. 11.3 μmol/l for LI; p = 0.037 and 16.3 vs. 12.7 μmol/l for CEI; p = 0.036). The same tendency was also observed for ATI, but the difference was only marginally significant probably due to the small number of the cases (13.4 vs. 11.9 μmol/l; p = 0.087). After adjustment for age, sex, hypertension, serum creatinine, total protein, folate and vitamin B12 levels, the risk of LI was not significant in the second tertile of the tHcy distribution, but significantly increased in the third compared with the first tertile (adjusted odds ratio, AOR, 3.4; 95% confidence limits, CL, 1.3-8.9; p = 0.015), while the risk of ATI was significant even in the second tertile (AOR, 5.0; 95% CL, 1.0-23.7; p = 0.042) and higher in the third tertile (AOR, 7.5; 95% CL, 1.5-38.3; p = 0.015). However, the odds ratios for CEI could not be estimated, as there was no case of CEI in the first tertile. These findings suggest that elevated tHcy is an independent risk factor for all subtypes of CI, but that its impact is higher in ATI and probably in CEI than in LI.

AB - Moderately elevated plasma total homocyst(e)ine (tHcy) levels have been linked with cardiovascular disease. However, the findings of previous studies regarding the relationship between tHcy levels and subtypes of cerebral infarction (CI) have been conflicting. The aim of the present study was to examine this issue in a community-based case-control study performed in Hisayama Town in Japan. Fasting tHcy levels were compared among 75 CI cases, of which 43 were lacunar (LI), 24 atherothrombotic (ATI) and 8 cardioembolic infarctions (CEI), and 248 age- and sex-matched healthy controls. The mean tHcy concentrations were higher in CI than in controls (13.0 vs. 11.8 μmol/l; p = 0.018). LI and CEI also had significantly higher tHcy levels than did the corresponding controls (12.3 vs. 11.3 μmol/l for LI; p = 0.037 and 16.3 vs. 12.7 μmol/l for CEI; p = 0.036). The same tendency was also observed for ATI, but the difference was only marginally significant probably due to the small number of the cases (13.4 vs. 11.9 μmol/l; p = 0.087). After adjustment for age, sex, hypertension, serum creatinine, total protein, folate and vitamin B12 levels, the risk of LI was not significant in the second tertile of the tHcy distribution, but significantly increased in the third compared with the first tertile (adjusted odds ratio, AOR, 3.4; 95% confidence limits, CL, 1.3-8.9; p = 0.015), while the risk of ATI was significant even in the second tertile (AOR, 5.0; 95% CL, 1.0-23.7; p = 0.042) and higher in the third tertile (AOR, 7.5; 95% CL, 1.5-38.3; p = 0.015). However, the odds ratios for CEI could not be estimated, as there was no case of CEI in the first tertile. These findings suggest that elevated tHcy is an independent risk factor for all subtypes of CI, but that its impact is higher in ATI and probably in CEI than in LI.

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