Plasma jet effectiveness alteration in acute wound healing by binahong (Anredera cordifolia) extract

Sri Darmawati, N. Nasruddin, P. Kurniasiwi, A. H. Mukaromah, A. Iswara, G. S.A. Putri, H. S.E. Rahayu, E. S. Wahyuningtyas, H. Lutfiyati, A. Kartikadewi, S. Rejeki, T. Ishijima, T. Nakatani, J. Sugama

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


An atmospheric pressure plasma jet (APPJ) using medical-grade argon gas as the carrier gas was developed and used to investigate wound healing in small animals com-bined with Binahong (Anredera cordifolia) leaf extract treatment. The experiment was divided into 4 treatment groups, control (C), plasma jet (P), Binahong leaf extract (B), and Binahong leaf extract followed by plasma jet (PB). Plasma jet treatment for wounds was applied in different styles based on the treatment day. Both P and PB treatments were contact-style for days 0–4 (5-mm distance for 1-min duration) and noncontact style for days 5–13 (20 mm for 3 min). The total period of wound observation was 14 days. Histological evaluation using hematoxylin-eosin (HE) staining was performed on days 7, 11, and 14 to evaluate wound re-epithelialization. Meanwhile, the number of neutrophil cells was counted using a hematology analyzer on days 11 and 14, and malondialdehyde (MDA) levels were examined on days 7 and 14. This research revealed that plasma jet successfully improved wound healing; on the other hand, plasma jet treatment preceded by Binahong leaf extract treatment tended to impede wound healing. It is hypothesized that Binahong may reduce plasma jet effectiveness in wound healing.

Original languageEnglish
Pages (from-to)259-271
Number of pages13
JournalPlasma Medicine
Issue number4
Publication statusPublished - 2020
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biomedical Engineering
  • Physics and Astronomy(all)


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