Plasma levels of IL-6 in patients with untreated major depressive disorder: Comparison with catecholamine metabolites

Reiji Yoshimura, Taro Kishi, Nakao Iwata

Research output: Contribution to journalArticle

Abstract

Objective: IL-6 and catecholamines play roles in the pathophysiology of major depressive disorder (MDD). Aim: The present study investigated associations between plasma IL-6 and plasma catecholamine metabolites in patients with MDD. Participants and methods: A total of 148 patients (male/female 65/83, age 49.5±12.1 years) who met the criteria for MDD based on the Diagnostic and Statistical Manual of Mental Disorders IV and 40 participants as healthy controls (HC; male/female 23/17, age 44.0±10.5 years) were enrolled in the present study. Plasma levels of 3-methoxy-4-hydroxyphenylglycol (MHPG) and homovanillic acid (HVA) were analyzed using high-performance liquid chromatography, and plasma IL-6 levels were measured using ELISA. Results: No correlations were observed among plasma IL-6 levels, MHPG levels, and HVA levels in patients with MDD. Plasma IL-6 levels in patients with MDD were significantly higher than in the HC. A positive correlation was found between plasma IL-6 levels and Hamilton Rating Scale for Depression-17 scores. Conclusion: No correlations existed between plasma IL-6 levels and plasma catecholamine metabolite levels in patients with MDD, and the severity of depressive state was related to plasma IL-6 levels in MDD.

Original languageEnglish
Pages (from-to)2655-2661
Number of pages7
JournalNeuropsychiatric Disease and Treatment
Volume15
DOIs
Publication statusPublished - 01-01-2019

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Major Depressive Disorder
Catecholamines
Interleukin-6
Homovanillic Acid
Diagnostic and Statistical Manual of Mental Disorders
Healthy Volunteers
Enzyme-Linked Immunosorbent Assay
High Pressure Liquid Chromatography
Depression

All Science Journal Classification (ASJC) codes

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

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title = "Plasma levels of IL-6 in patients with untreated major depressive disorder: Comparison with catecholamine metabolites",
abstract = "Objective: IL-6 and catecholamines play roles in the pathophysiology of major depressive disorder (MDD). Aim: The present study investigated associations between plasma IL-6 and plasma catecholamine metabolites in patients with MDD. Participants and methods: A total of 148 patients (male/female 65/83, age 49.5±12.1 years) who met the criteria for MDD based on the Diagnostic and Statistical Manual of Mental Disorders IV and 40 participants as healthy controls (HC; male/female 23/17, age 44.0±10.5 years) were enrolled in the present study. Plasma levels of 3-methoxy-4-hydroxyphenylglycol (MHPG) and homovanillic acid (HVA) were analyzed using high-performance liquid chromatography, and plasma IL-6 levels were measured using ELISA. Results: No correlations were observed among plasma IL-6 levels, MHPG levels, and HVA levels in patients with MDD. Plasma IL-6 levels in patients with MDD were significantly higher than in the HC. A positive correlation was found between plasma IL-6 levels and Hamilton Rating Scale for Depression-17 scores. Conclusion: No correlations existed between plasma IL-6 levels and plasma catecholamine metabolite levels in patients with MDD, and the severity of depressive state was related to plasma IL-6 levels in MDD.",
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Plasma levels of IL-6 in patients with untreated major depressive disorder : Comparison with catecholamine metabolites. / Yoshimura, Reiji; Kishi, Taro; Iwata, Nakao.

In: Neuropsychiatric Disease and Treatment, Vol. 15, 01.01.2019, p. 2655-2661.

Research output: Contribution to journalArticle

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