TY - JOUR
T1 - Plasma levels of IL-6 in patients with untreated major depressive disorder
T2 - Comparison with catecholamine metabolites
AU - Yoshimura, Reiji
AU - Kishi, Taro
AU - Iwata, Nakao
N1 - Publisher Copyright:
© 2019 Thomas et al.
PY - 2019
Y1 - 2019
N2 - Objective: IL-6 and catecholamines play roles in the pathophysiology of major depressive disorder (MDD). Aim: The present study investigated associations between plasma IL-6 and plasma catecholamine metabolites in patients with MDD. Participants and methods: A total of 148 patients (male/female 65/83, age 49.5±12.1 years) who met the criteria for MDD based on the Diagnostic and Statistical Manual of Mental Disorders IV and 40 participants as healthy controls (HC; male/female 23/17, age 44.0±10.5 years) were enrolled in the present study. Plasma levels of 3-methoxy-4-hydroxyphenylglycol (MHPG) and homovanillic acid (HVA) were analyzed using high-performance liquid chromatography, and plasma IL-6 levels were measured using ELISA. Results: No correlations were observed among plasma IL-6 levels, MHPG levels, and HVA levels in patients with MDD. Plasma IL-6 levels in patients with MDD were significantly higher than in the HC. A positive correlation was found between plasma IL-6 levels and Hamilton Rating Scale for Depression-17 scores. Conclusion: No correlations existed between plasma IL-6 levels and plasma catecholamine metabolite levels in patients with MDD, and the severity of depressive state was related to plasma IL-6 levels in MDD.
AB - Objective: IL-6 and catecholamines play roles in the pathophysiology of major depressive disorder (MDD). Aim: The present study investigated associations between plasma IL-6 and plasma catecholamine metabolites in patients with MDD. Participants and methods: A total of 148 patients (male/female 65/83, age 49.5±12.1 years) who met the criteria for MDD based on the Diagnostic and Statistical Manual of Mental Disorders IV and 40 participants as healthy controls (HC; male/female 23/17, age 44.0±10.5 years) were enrolled in the present study. Plasma levels of 3-methoxy-4-hydroxyphenylglycol (MHPG) and homovanillic acid (HVA) were analyzed using high-performance liquid chromatography, and plasma IL-6 levels were measured using ELISA. Results: No correlations were observed among plasma IL-6 levels, MHPG levels, and HVA levels in patients with MDD. Plasma IL-6 levels in patients with MDD were significantly higher than in the HC. A positive correlation was found between plasma IL-6 levels and Hamilton Rating Scale for Depression-17 scores. Conclusion: No correlations existed between plasma IL-6 levels and plasma catecholamine metabolite levels in patients with MDD, and the severity of depressive state was related to plasma IL-6 levels in MDD.
KW - 3-methoxy-4-hydroxyphenylglycol
KW - Hamilton rating scale for depression
KW - Homovanillic acid
KW - Il-6
KW - Major depressive disorder
UR - http://www.scopus.com/inward/record.url?scp=85073354524&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85073354524&partnerID=8YFLogxK
U2 - 10.2147/NDT.S195379
DO - 10.2147/NDT.S195379
M3 - Article
AN - SCOPUS:85073354524
SN - 1176-6328
VL - 15
SP - 2655
EP - 2661
JO - Neuropsychiatric Disease and Treatment
JF - Neuropsychiatric Disease and Treatment
ER -
