Pneumonitis induced by ou-gon (scullcap)

Kei Takeshita, Yoshifumi Saisho, Kumi Kitamura, Noriko Kaburagi, Tomohiro Funabiki, Toshiyuki Inamura, Yoshitaka Oyamada, Koichiro Asano, Kazuhiro Yamaguchi

Research output: Contribution to journalArticlepeer-review

35 Citations (Scopus)


A 53-year-old Japanese man with recurrent interstitial pneumonia was referred to us. The patient had taken a traditional herb medicine, otsu-ji-to, before the onset of pneumonia. A provocation test for each herbal ingredient contained in otsu-ji-to revealed that the pneumonitis had been induced by ou-gon (scullcap). Lymphocytosis with the CD8+ T-cell subset predominance was found in the bronchoalveolar lavage fluid and lymphocytic alveolitis was noted in the transbronchial lung biopsy specimen after the provocation test. Ou-gon, or scullcap, should be included in the list of drugs with definite causal association with pneumonitis.

Original languageEnglish
Pages (from-to)764-768
Number of pages5
JournalInternal Medicine
Issue number8
Publication statusPublished - 08-2001
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Internal Medicine


Dive into the research topics of 'Pneumonitis induced by ou-gon (scullcap)'. Together they form a unique fingerprint.

Cite this