TY - JOUR
T1 - Polygenic risk score for blood pressure and lifestyle factors with overall and CVD mortality
T2 - a prospective cohort study in a Japanese population
AU - for the J-MICC Study Group
AU - Fujii, Ryosuke
AU - Hishida, Asahi
AU - Nakatochi, Masahiro
AU - Okumiyama, Hiroshi
AU - Takashima, Naoyuki
AU - Tsuboi, Yoshiki
AU - Suzuki, Koji
AU - Ikezaki, Hiroaki
AU - Shimanoe, Chisato
AU - Kato, Yasufumi
AU - Tamura, Takashi
AU - Ito, Hidemi
AU - Michihata, Nobuaki
AU - Tanoue, Shiroh
AU - Suzuki, Sadao
AU - Kuriki, Kiyonori
AU - Kadota, Aya
AU - Watanabe, Takeshi
AU - Momozawa, Yukihide
AU - Wakai, Kenji
AU - Matsuo, Keitaro
AU - Koriyama, Chihaya
AU - Tanaka, Keitaro
AU - Katsuura-Kamano, Sakurako
AU - Koyama, Teruhide
AU - Miura, Katsuyuki
AU - Kita, Yoshikuni
AU - Narimatsu, Hiroto
AU - Matsuo, Keitaro
N1 - Publisher Copyright:
© The Author(s), under exclusive licence to The Japanese Society of Hypertension 2024.
PY - 2024/9
Y1 - 2024/9
N2 - Although previous polygenic risk score (PRS) studies for cardiovascular disease (CVD) focused on incidence, few studies addressed CVD mortality and quantified risks by environmental exposures in different genetic liability groups. This prospective study aimed to examine the associations of blood pressure PRS with all-cause and CVD mortality and to quantify the attributable risk by modifiable lifestyles across different PRS strata. 9,296 participants in the Japan Multi-Institutional Collaborative Cohort Study without hypertension at baseline were analyzed in this analysis. PRS for systolic blood pressure and diastolic blood pressure (PRSSBP and PRSDBP) were developed using publicly available Biobank Japan GWAS summary statistics. CVD-related mortality was defined by the International Classification of Diseases 10th version (I00-I99). Cox-proportional hazard model was used to examine associations of PRSs and lifestyle variables (smoking, drinking, and dietary sodium intake) with mortality. During a median 12.6-year follow-up period, we observed 273 all-cause and 41 CVD mortality cases. Compared to the middle PRS group (20–80th percentile), adjusted hazard ratios for CVD mortality at the top PRS group (> 90th percentile) were 3.67 for PRSSBP and 2.92 for PRSDBP. Attributable risks of CVD mortality by modifiable lifestyles were higher in the high PRS group (> 80th percentile) compared with the low PRS group (0–80th percentile). In summary, blood pressure PRS is associated with CVD mortality in the general Japanese population. Our study implies that integrating PRS with lifestyle could contribute to identify target populations for lifestyle intervention even though improvement of discriminatory ability by PRS alone is limited. (Figure presented.)
AB - Although previous polygenic risk score (PRS) studies for cardiovascular disease (CVD) focused on incidence, few studies addressed CVD mortality and quantified risks by environmental exposures in different genetic liability groups. This prospective study aimed to examine the associations of blood pressure PRS with all-cause and CVD mortality and to quantify the attributable risk by modifiable lifestyles across different PRS strata. 9,296 participants in the Japan Multi-Institutional Collaborative Cohort Study without hypertension at baseline were analyzed in this analysis. PRS for systolic blood pressure and diastolic blood pressure (PRSSBP and PRSDBP) were developed using publicly available Biobank Japan GWAS summary statistics. CVD-related mortality was defined by the International Classification of Diseases 10th version (I00-I99). Cox-proportional hazard model was used to examine associations of PRSs and lifestyle variables (smoking, drinking, and dietary sodium intake) with mortality. During a median 12.6-year follow-up period, we observed 273 all-cause and 41 CVD mortality cases. Compared to the middle PRS group (20–80th percentile), adjusted hazard ratios for CVD mortality at the top PRS group (> 90th percentile) were 3.67 for PRSSBP and 2.92 for PRSDBP. Attributable risks of CVD mortality by modifiable lifestyles were higher in the high PRS group (> 80th percentile) compared with the low PRS group (0–80th percentile). In summary, blood pressure PRS is associated with CVD mortality in the general Japanese population. Our study implies that integrating PRS with lifestyle could contribute to identify target populations for lifestyle intervention even though improvement of discriminatory ability by PRS alone is limited. (Figure presented.)
KW - GWAS
KW - blood pressure
KW - cardiovascular disease
KW - cohort study
KW - polygenic risk score
UR - http://www.scopus.com/inward/record.url?scp=85198643042&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85198643042&partnerID=8YFLogxK
U2 - 10.1038/s41440-024-01766-9
DO - 10.1038/s41440-024-01766-9
M3 - Article
C2 - 38961281
AN - SCOPUS:85198643042
SN - 0916-9636
VL - 47
SP - 2284
EP - 2294
JO - Hypertension Research
JF - Hypertension Research
IS - 9
ER -