Polygenic risk scores for low-density lipoprotein cholesterol and familial hypercholesterolemia

Akihiro Nomura, Takehiro Sato, Hayato Tada, Takayuki Kannon, Kazuyoshi Hosomichi, Hiromasa Tsujiguchi, Hiroyuki Nakamura, Masayuki Takamura, Atsushi Tajima, Masa aki Kawashiri

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

Familial hypercholesterolemia (FH) is an autosomal dominant monogenic disorder characterized by elevated levels of low-density lipoprotein cholesterol (LDL-C) and an increased risk of premature coronary artery disease (CAD). Recently, it has been shown that a high polygenic risk score (PRS) could be an independent risk factor for CAD in FH patients of European ancestry. However, it is uncertain whether PRS is also useful for risk stratification of FH patients in East Asia. We recruited and genotyped clinically diagnosed FH (CDFH) patients from the Kanazawa University Mendelian Disease FH registry and controls from the Shikamachi Health Improvement Practice genome cohort in Japan. We calculated PRS from 3.6 million variants of each participant (imputed from the 1000 Genome phase 3 Asian dataset) for LDL-C (PRSLDLC) using a genome-wide association study summary statistic from the BioBank Japan Project. We assessed the association of PRSLDLC with LDL-C and CAD among and within monogenic FH, mutation negative CDFH, and controls. We tested a total of 1223 participants (376 FH patients, including 173 with monogenic FH and 203 with mutation negative CDFH, and 847 controls) for the analyses. PRSLDLC was significantly higher in mutation negative CDFH patients than in controls (p = 3.1 × 10−13). PRSLDLC was also significantly linked to LDL-C in controls (p trend = 3.6 × 10−4) but not in FH patients. Moreover, we could not detect any association between PRSLDLC and CAD in any of the groups. In conclusion, mutation negative CDFH patients demonstrated significantly higher PRSLDLC than controls. However, PRSLDLC may have little additional effect on LDL-C and CAD among FH patients.

Original languageEnglish
Pages (from-to)1079-1087
Number of pages9
JournalJournal of Human Genetics
Volume66
Issue number11
DOIs
Publication statusPublished - 11-2021
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Genetics
  • Genetics(clinical)

Fingerprint

Dive into the research topics of 'Polygenic risk scores for low-density lipoprotein cholesterol and familial hypercholesterolemia'. Together they form a unique fingerprint.

Cite this