PolyI:C-induced neurodevelopmental animal model for schizophrenia

Daisuke Ibi, Taku Nagai, Toshitaka Nabeshima, Kiyofumi Yamada

Research output: Contribution to journalReview article

8 Citations (Scopus)

Abstract

Schizophrenia affects nearly 1% of the population and is clinically characterized by positive symptoms (e.g. delusions and hallucinations), negative symptoms (e.g. affective flattening, apathy and social withdrawal) and cognitive dysfunction. Genetic susceptibility factors for schizophrenia, such as neuregulin1, dysbindin and disrupted-in-schizophrenia 1 (DISC1), have recently been reported, some of which play a role in neurodevelopment. Furthermore, epidemiologic studies suggest that environmental insults, such as prenatal infection and perinatal complication, are involved in the development of schizophrenia. The possible interaction between environment and genetic susceptibility factors is proposed as a promising disease etiology of schizophrenia. Polyriboinosinic-polyribocytidylic acid (polyI:C), a toll-like receptor 3 ligand, induces a strong innate immune response. Maternal immune activation by polyI:C exposure in rodents induces a wide spectrum of behavioral and neurochemical abnormalities in adult offspring. We have reported that neonatal injection of polyI:C in mice results in schizophrenia-like behavioral abnormalities in adulthood. In this review, we show how gene-environment interactions during neurodevelopment result in phenotypic changes in adulthood, by injecting polyI:C into transgenic mice that express a dominant-negative form of human DISC1 (DN-DISC1). Our findings suggest that polyI:C-treated DN-DISC1 mice are a validated animal model for schizophrenia with gene-environment interactions.

Original languageEnglish
Pages (from-to)201-207
Number of pages7
JournalJapanese Journal of Neuropsychopharmacology
Volume31
Issue number5-6
Publication statusPublished - 01-11-2011

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Schizophrenia
Animal Models
Gene-Environment Interaction
Acids
Genetic Predisposition to Disease
Toll-Like Receptor 3
Apathy
Affective Symptoms
Delusions
Hallucinations
Innate Immunity
Transgenic Mice
Epidemiologic Studies
Rodentia
Mothers
Ligands
Injections
Infection
Population

All Science Journal Classification (ASJC) codes

  • Clinical Psychology
  • Pharmacology
  • Psychiatry and Mental health
  • Pharmacology (medical)

Cite this

Ibi, Daisuke ; Nagai, Taku ; Nabeshima, Toshitaka ; Yamada, Kiyofumi. / PolyI:C-induced neurodevelopmental animal model for schizophrenia. In: Japanese Journal of Neuropsychopharmacology. 2011 ; Vol. 31, No. 5-6. pp. 201-207.
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PolyI:C-induced neurodevelopmental animal model for schizophrenia. / Ibi, Daisuke; Nagai, Taku; Nabeshima, Toshitaka; Yamada, Kiyofumi.

In: Japanese Journal of Neuropsychopharmacology, Vol. 31, No. 5-6, 01.11.2011, p. 201-207.

Research output: Contribution to journalReview article

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