Polymorphism in the sorbin and SH3-domain-containing-1 (SORBS1) gene and the risk of brain infarction in the Japanese population: The Fukuoka Stroke Registry and the Hisayama study

N. Hagiwara, T. Kitazono, M. Kamouchi, J. Kuroda, T. Ago, J. Hata, T. Ninomiya, H. Ooboshi, Y. Kumai, S. Yoshimura, K. Tamaki, K. Fujii, T. Nagao, Y. Okada, K. Toyoda, H. Nakane, H. Sugimori, Y. Yamashita, Y. Wakugawa, M. KuboY. Tanizaki, Y. Kiyohara, S. Ibayashi, M. Iida

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background and purpose: Sorbin and SH3-domain-containing-1 (SORBS1) is an important adaptor protein in insulin-signalling pathway, and its genetic polymorphism may regulate the activity of insulin resistance. We investigated the association between the SORBS1 T228A polymorphism and ischaemic stroke. Methods: Genotyping was achieved by a rapid-cycle PCR and melting curve analysis using fluorescent probes in 1049 incident cases of ischaemic stroke and 1049 age- and sex-matched control subjects recruited from the Hisayama study. Results: The allele distributions of the SORBS1 T228A polymorphism were similar amongst cases and controls. The multivariate-adjusted odds ratio (OR) of the AA genotype for ischaemic stroke was 2.897 (95% CI, 0.907-8.018) compared with the TT genotype. In terms of stroke subtype, there was a trend toward a difference in the AA genotypes for lacunar infarction, compared with the TT genotype (OR = 8.740, P = 0.0510), and combined TT and TA genotypes (OR = 8.768, P = 0.0505). The other polymorphisms genotyped were not associated with any subtypes of ischaemic stroke. T228A polymorphism of SORBS1 was not associated with the prevalence of diabetes. Conclusions: The AA genotype of SORBS1 T228A polymorphism may play a role in lacunar infarction in the Japanese population.

Original languageEnglish
Pages (from-to)481-486
Number of pages6
JournalEuropean Journal of Neurology
Volume15
Issue number5
DOIs
Publication statusPublished - 01-05-2008

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

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    Hagiwara, N., Kitazono, T., Kamouchi, M., Kuroda, J., Ago, T., Hata, J., Ninomiya, T., Ooboshi, H., Kumai, Y., Yoshimura, S., Tamaki, K., Fujii, K., Nagao, T., Okada, Y., Toyoda, K., Nakane, H., Sugimori, H., Yamashita, Y., Wakugawa, Y., ... Iida, M. (2008). Polymorphism in the sorbin and SH3-domain-containing-1 (SORBS1) gene and the risk of brain infarction in the Japanese population: The Fukuoka Stroke Registry and the Hisayama study. European Journal of Neurology, 15(5), 481-486. https://doi.org/10.1111/j.1468-1331.2008.02105.x