Polymorphism in the sorbin and SH3-domain-containing-1 (SORBS1) gene and the risk of brain infarction in the Japanese population

The Fukuoka Stroke Registry and the Hisayama study

N. Hagiwara, T. Kitazono, M. Kamouchi, J. Kuroda, T. Ago, J. Hata, T. Ninomiya, H. Ooboshi, Y. Kumai, S. Yoshimura, K. Tamaki, K. Fujii, T. Nagao, Y. Okada, K. Toyoda, H. Nakane, H. Sugimori, Y. Yamashita, Y. Wakugawa, Michiaki Kubo & 4 others Y. Tanizaki, Y. Kiyohara, S. Ibayashi, M. Iida

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background and purpose: Sorbin and SH3-domain-containing-1 (SORBS1) is an important adaptor protein in insulin-signalling pathway, and its genetic polymorphism may regulate the activity of insulin resistance. We investigated the association between the SORBS1 T228A polymorphism and ischaemic stroke. Methods: Genotyping was achieved by a rapid-cycle PCR and melting curve analysis using fluorescent probes in 1049 incident cases of ischaemic stroke and 1049 age- and sex-matched control subjects recruited from the Hisayama study. Results: The allele distributions of the SORBS1 T228A polymorphism were similar amongst cases and controls. The multivariate-adjusted odds ratio (OR) of the AA genotype for ischaemic stroke was 2.897 (95% CI, 0.907-8.018) compared with the TT genotype. In terms of stroke subtype, there was a trend toward a difference in the AA genotypes for lacunar infarction, compared with the TT genotype (OR = 8.740, P = 0.0510), and combined TT and TA genotypes (OR = 8.768, P = 0.0505). The other polymorphisms genotyped were not associated with any subtypes of ischaemic stroke. T228A polymorphism of SORBS1 was not associated with the prevalence of diabetes. Conclusions: The AA genotype of SORBS1 T228A polymorphism may play a role in lacunar infarction in the Japanese population.

Original languageEnglish
Pages (from-to)481-486
Number of pages6
JournalEuropean Journal of Neurology
Volume15
Issue number5
DOIs
Publication statusPublished - 01-05-2008
Externally publishedYes

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Brain Infarction
src Homology Domains
Registries
Stroke
Genotype
Population
Genes
Lacunar Stroke
Odds Ratio
Genetic Polymorphisms
Fluorescent Dyes
Freezing
Insulin Resistance
Alleles
Insulin
Polymerase Chain Reaction

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

Cite this

Hagiwara, N. ; Kitazono, T. ; Kamouchi, M. ; Kuroda, J. ; Ago, T. ; Hata, J. ; Ninomiya, T. ; Ooboshi, H. ; Kumai, Y. ; Yoshimura, S. ; Tamaki, K. ; Fujii, K. ; Nagao, T. ; Okada, Y. ; Toyoda, K. ; Nakane, H. ; Sugimori, H. ; Yamashita, Y. ; Wakugawa, Y. ; Kubo, Michiaki ; Tanizaki, Y. ; Kiyohara, Y. ; Ibayashi, S. ; Iida, M. / Polymorphism in the sorbin and SH3-domain-containing-1 (SORBS1) gene and the risk of brain infarction in the Japanese population : The Fukuoka Stroke Registry and the Hisayama study. In: European Journal of Neurology. 2008 ; Vol. 15, No. 5. pp. 481-486.
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title = "Polymorphism in the sorbin and SH3-domain-containing-1 (SORBS1) gene and the risk of brain infarction in the Japanese population: The Fukuoka Stroke Registry and the Hisayama study",
abstract = "Background and purpose: Sorbin and SH3-domain-containing-1 (SORBS1) is an important adaptor protein in insulin-signalling pathway, and its genetic polymorphism may regulate the activity of insulin resistance. We investigated the association between the SORBS1 T228A polymorphism and ischaemic stroke. Methods: Genotyping was achieved by a rapid-cycle PCR and melting curve analysis using fluorescent probes in 1049 incident cases of ischaemic stroke and 1049 age- and sex-matched control subjects recruited from the Hisayama study. Results: The allele distributions of the SORBS1 T228A polymorphism were similar amongst cases and controls. The multivariate-adjusted odds ratio (OR) of the AA genotype for ischaemic stroke was 2.897 (95{\%} CI, 0.907-8.018) compared with the TT genotype. In terms of stroke subtype, there was a trend toward a difference in the AA genotypes for lacunar infarction, compared with the TT genotype (OR = 8.740, P = 0.0510), and combined TT and TA genotypes (OR = 8.768, P = 0.0505). The other polymorphisms genotyped were not associated with any subtypes of ischaemic stroke. T228A polymorphism of SORBS1 was not associated with the prevalence of diabetes. Conclusions: The AA genotype of SORBS1 T228A polymorphism may play a role in lacunar infarction in the Japanese population.",
author = "N. Hagiwara and T. Kitazono and M. Kamouchi and J. Kuroda and T. Ago and J. Hata and T. Ninomiya and H. Ooboshi and Y. Kumai and S. Yoshimura and K. Tamaki and K. Fujii and T. Nagao and Y. Okada and K. Toyoda and H. Nakane and H. Sugimori and Y. Yamashita and Y. Wakugawa and Michiaki Kubo and Y. Tanizaki and Y. Kiyohara and S. Ibayashi and M. Iida",
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Hagiwara, N, Kitazono, T, Kamouchi, M, Kuroda, J, Ago, T, Hata, J, Ninomiya, T, Ooboshi, H, Kumai, Y, Yoshimura, S, Tamaki, K, Fujii, K, Nagao, T, Okada, Y, Toyoda, K, Nakane, H, Sugimori, H, Yamashita, Y, Wakugawa, Y, Kubo, M, Tanizaki, Y, Kiyohara, Y, Ibayashi, S & Iida, M 2008, 'Polymorphism in the sorbin and SH3-domain-containing-1 (SORBS1) gene and the risk of brain infarction in the Japanese population: The Fukuoka Stroke Registry and the Hisayama study', European Journal of Neurology, vol. 15, no. 5, pp. 481-486. https://doi.org/10.1111/j.1468-1331.2008.02105.x

Polymorphism in the sorbin and SH3-domain-containing-1 (SORBS1) gene and the risk of brain infarction in the Japanese population : The Fukuoka Stroke Registry and the Hisayama study. / Hagiwara, N.; Kitazono, T.; Kamouchi, M.; Kuroda, J.; Ago, T.; Hata, J.; Ninomiya, T.; Ooboshi, H.; Kumai, Y.; Yoshimura, S.; Tamaki, K.; Fujii, K.; Nagao, T.; Okada, Y.; Toyoda, K.; Nakane, H.; Sugimori, H.; Yamashita, Y.; Wakugawa, Y.; Kubo, Michiaki; Tanizaki, Y.; Kiyohara, Y.; Ibayashi, S.; Iida, M.

In: European Journal of Neurology, Vol. 15, No. 5, 01.05.2008, p. 481-486.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Polymorphism in the sorbin and SH3-domain-containing-1 (SORBS1) gene and the risk of brain infarction in the Japanese population

T2 - The Fukuoka Stroke Registry and the Hisayama study

AU - Hagiwara, N.

AU - Kitazono, T.

AU - Kamouchi, M.

AU - Kuroda, J.

AU - Ago, T.

AU - Hata, J.

AU - Ninomiya, T.

AU - Ooboshi, H.

AU - Kumai, Y.

AU - Yoshimura, S.

AU - Tamaki, K.

AU - Fujii, K.

AU - Nagao, T.

AU - Okada, Y.

AU - Toyoda, K.

AU - Nakane, H.

AU - Sugimori, H.

AU - Yamashita, Y.

AU - Wakugawa, Y.

AU - Kubo, Michiaki

AU - Tanizaki, Y.

AU - Kiyohara, Y.

AU - Ibayashi, S.

AU - Iida, M.

PY - 2008/5/1

Y1 - 2008/5/1

N2 - Background and purpose: Sorbin and SH3-domain-containing-1 (SORBS1) is an important adaptor protein in insulin-signalling pathway, and its genetic polymorphism may regulate the activity of insulin resistance. We investigated the association between the SORBS1 T228A polymorphism and ischaemic stroke. Methods: Genotyping was achieved by a rapid-cycle PCR and melting curve analysis using fluorescent probes in 1049 incident cases of ischaemic stroke and 1049 age- and sex-matched control subjects recruited from the Hisayama study. Results: The allele distributions of the SORBS1 T228A polymorphism were similar amongst cases and controls. The multivariate-adjusted odds ratio (OR) of the AA genotype for ischaemic stroke was 2.897 (95% CI, 0.907-8.018) compared with the TT genotype. In terms of stroke subtype, there was a trend toward a difference in the AA genotypes for lacunar infarction, compared with the TT genotype (OR = 8.740, P = 0.0510), and combined TT and TA genotypes (OR = 8.768, P = 0.0505). The other polymorphisms genotyped were not associated with any subtypes of ischaemic stroke. T228A polymorphism of SORBS1 was not associated with the prevalence of diabetes. Conclusions: The AA genotype of SORBS1 T228A polymorphism may play a role in lacunar infarction in the Japanese population.

AB - Background and purpose: Sorbin and SH3-domain-containing-1 (SORBS1) is an important adaptor protein in insulin-signalling pathway, and its genetic polymorphism may regulate the activity of insulin resistance. We investigated the association between the SORBS1 T228A polymorphism and ischaemic stroke. Methods: Genotyping was achieved by a rapid-cycle PCR and melting curve analysis using fluorescent probes in 1049 incident cases of ischaemic stroke and 1049 age- and sex-matched control subjects recruited from the Hisayama study. Results: The allele distributions of the SORBS1 T228A polymorphism were similar amongst cases and controls. The multivariate-adjusted odds ratio (OR) of the AA genotype for ischaemic stroke was 2.897 (95% CI, 0.907-8.018) compared with the TT genotype. In terms of stroke subtype, there was a trend toward a difference in the AA genotypes for lacunar infarction, compared with the TT genotype (OR = 8.740, P = 0.0510), and combined TT and TA genotypes (OR = 8.768, P = 0.0505). The other polymorphisms genotyped were not associated with any subtypes of ischaemic stroke. T228A polymorphism of SORBS1 was not associated with the prevalence of diabetes. Conclusions: The AA genotype of SORBS1 T228A polymorphism may play a role in lacunar infarction in the Japanese population.

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U2 - 10.1111/j.1468-1331.2008.02105.x

DO - 10.1111/j.1468-1331.2008.02105.x

M3 - Article

VL - 15

SP - 481

EP - 486

JO - European Journal of Neurology

JF - European Journal of Neurology

SN - 1351-5101

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