TY - JOUR
T1 - Polymorphism in the sorbin and SH3-domain-containing-1 (SORBS1) gene and the risk of brain infarction in the Japanese population
T2 - The Fukuoka Stroke Registry and the Hisayama study
AU - Hagiwara, N.
AU - Kitazono, T.
AU - Kamouchi, M.
AU - Kuroda, J.
AU - Ago, T.
AU - Hata, J.
AU - Ninomiya, T.
AU - Ooboshi, H.
AU - Kumai, Y.
AU - Yoshimura, S.
AU - Tamaki, K.
AU - Fujii, K.
AU - Nagao, T.
AU - Okada, Y.
AU - Toyoda, K.
AU - Nakane, H.
AU - Sugimori, H.
AU - Yamashita, Y.
AU - Wakugawa, Y.
AU - Kubo, M.
AU - Tanizaki, Y.
AU - Kiyohara, Y.
AU - Ibayashi, S.
AU - Iida, M.
PY - 2008/5
Y1 - 2008/5
N2 - Background and purpose: Sorbin and SH3-domain-containing-1 (SORBS1) is an important adaptor protein in insulin-signalling pathway, and its genetic polymorphism may regulate the activity of insulin resistance. We investigated the association between the SORBS1 T228A polymorphism and ischaemic stroke. Methods: Genotyping was achieved by a rapid-cycle PCR and melting curve analysis using fluorescent probes in 1049 incident cases of ischaemic stroke and 1049 age- and sex-matched control subjects recruited from the Hisayama study. Results: The allele distributions of the SORBS1 T228A polymorphism were similar amongst cases and controls. The multivariate-adjusted odds ratio (OR) of the AA genotype for ischaemic stroke was 2.897 (95% CI, 0.907-8.018) compared with the TT genotype. In terms of stroke subtype, there was a trend toward a difference in the AA genotypes for lacunar infarction, compared with the TT genotype (OR = 8.740, P = 0.0510), and combined TT and TA genotypes (OR = 8.768, P = 0.0505). The other polymorphisms genotyped were not associated with any subtypes of ischaemic stroke. T228A polymorphism of SORBS1 was not associated with the prevalence of diabetes. Conclusions: The AA genotype of SORBS1 T228A polymorphism may play a role in lacunar infarction in the Japanese population.
AB - Background and purpose: Sorbin and SH3-domain-containing-1 (SORBS1) is an important adaptor protein in insulin-signalling pathway, and its genetic polymorphism may regulate the activity of insulin resistance. We investigated the association between the SORBS1 T228A polymorphism and ischaemic stroke. Methods: Genotyping was achieved by a rapid-cycle PCR and melting curve analysis using fluorescent probes in 1049 incident cases of ischaemic stroke and 1049 age- and sex-matched control subjects recruited from the Hisayama study. Results: The allele distributions of the SORBS1 T228A polymorphism were similar amongst cases and controls. The multivariate-adjusted odds ratio (OR) of the AA genotype for ischaemic stroke was 2.897 (95% CI, 0.907-8.018) compared with the TT genotype. In terms of stroke subtype, there was a trend toward a difference in the AA genotypes for lacunar infarction, compared with the TT genotype (OR = 8.740, P = 0.0510), and combined TT and TA genotypes (OR = 8.768, P = 0.0505). The other polymorphisms genotyped were not associated with any subtypes of ischaemic stroke. T228A polymorphism of SORBS1 was not associated with the prevalence of diabetes. Conclusions: The AA genotype of SORBS1 T228A polymorphism may play a role in lacunar infarction in the Japanese population.
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U2 - 10.1111/j.1468-1331.2008.02105.x
DO - 10.1111/j.1468-1331.2008.02105.x
M3 - Article
C2 - 18394047
AN - SCOPUS:41849132819
SN - 1351-5101
VL - 15
SP - 481
EP - 486
JO - European Journal of Neurology
JF - European Journal of Neurology
IS - 5
ER -
