Polymorphism of peroxisome proliferator-activated receptor gamma is not associated to Japanese ulcerative colitis

Fangyu Wang, Tomomitsu Tahara, Tomiyasu Arisawa, Mikijyu Sakata, Kazuya Takahama, Makoto Watanabe, Ichiro Hirata, Hiroshi Nakano

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background/Aims: Expression of peroxisome proliferator-activated receptor gamma (PPARγ) has been reported to be impaired in patients with ulcerative colitis (UC), and activation of PPARγ is proved to inhibit the intestinal inflammation. As Plo12Ala polymorphism in codon 12 of the PPARγ gene may decrease the promoter activity, we investigated the influences of PPARγ polymorphism on the risk of UC in Japanese population. Methodology: The study recruited 118 patients with UC and 142 health controls. Plo12Ala polymorphisms of PPARγ were detected by polymerase chain reaction based restricted fragment length polymorphism. Results: The frequency of Pro/Alo heterozygotes of PPARγ gene in UC and control group was 4.2% and 4.9%, respectively. No significant difference was found between UC and control group (P=1.00, Fisher's exact test). Plo12Ala genotype of PPARγ did not show significant association with UC risk (OR=0.85, 95%CI=0.26-2.76). Conclusions: Our research suggests that Plo12Ala polymorphism of PPARγ may not be associated with the risk of developing ulcerative colitis in Japanese population.

Original languageEnglish
Pages (from-to)73-75
Number of pages3
JournalHepato-gastroenterology
Volume55
Issue number81
Publication statusPublished - 01-01-2008

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PPAR gamma
Ulcerative Colitis
Control Groups
Heterozygote
Codon
Population
Genes
Genotype
Inflammation
Polymerase Chain Reaction
Health
Research

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

Cite this

Wang, F., Tahara, T., Arisawa, T., Sakata, M., Takahama, K., Watanabe, M., ... Nakano, H. (2008). Polymorphism of peroxisome proliferator-activated receptor gamma is not associated to Japanese ulcerative colitis. Hepato-gastroenterology, 55(81), 73-75.
Wang, Fangyu ; Tahara, Tomomitsu ; Arisawa, Tomiyasu ; Sakata, Mikijyu ; Takahama, Kazuya ; Watanabe, Makoto ; Hirata, Ichiro ; Nakano, Hiroshi. / Polymorphism of peroxisome proliferator-activated receptor gamma is not associated to Japanese ulcerative colitis. In: Hepato-gastroenterology. 2008 ; Vol. 55, No. 81. pp. 73-75.
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title = "Polymorphism of peroxisome proliferator-activated receptor gamma is not associated to Japanese ulcerative colitis",
abstract = "Background/Aims: Expression of peroxisome proliferator-activated receptor gamma (PPARγ) has been reported to be impaired in patients with ulcerative colitis (UC), and activation of PPARγ is proved to inhibit the intestinal inflammation. As Plo12Ala polymorphism in codon 12 of the PPARγ gene may decrease the promoter activity, we investigated the influences of PPARγ polymorphism on the risk of UC in Japanese population. Methodology: The study recruited 118 patients with UC and 142 health controls. Plo12Ala polymorphisms of PPARγ were detected by polymerase chain reaction based restricted fragment length polymorphism. Results: The frequency of Pro/Alo heterozygotes of PPARγ gene in UC and control group was 4.2{\%} and 4.9{\%}, respectively. No significant difference was found between UC and control group (P=1.00, Fisher's exact test). Plo12Ala genotype of PPARγ did not show significant association with UC risk (OR=0.85, 95{\%}CI=0.26-2.76). Conclusions: Our research suggests that Plo12Ala polymorphism of PPARγ may not be associated with the risk of developing ulcerative colitis in Japanese population.",
author = "Fangyu Wang and Tomomitsu Tahara and Tomiyasu Arisawa and Mikijyu Sakata and Kazuya Takahama and Makoto Watanabe and Ichiro Hirata and Hiroshi Nakano",
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Wang, F, Tahara, T, Arisawa, T, Sakata, M, Takahama, K, Watanabe, M, Hirata, I & Nakano, H 2008, 'Polymorphism of peroxisome proliferator-activated receptor gamma is not associated to Japanese ulcerative colitis', Hepato-gastroenterology, vol. 55, no. 81, pp. 73-75.

Polymorphism of peroxisome proliferator-activated receptor gamma is not associated to Japanese ulcerative colitis. / Wang, Fangyu; Tahara, Tomomitsu; Arisawa, Tomiyasu; Sakata, Mikijyu; Takahama, Kazuya; Watanabe, Makoto; Hirata, Ichiro; Nakano, Hiroshi.

In: Hepato-gastroenterology, Vol. 55, No. 81, 01.01.2008, p. 73-75.

Research output: Contribution to journalArticle

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T1 - Polymorphism of peroxisome proliferator-activated receptor gamma is not associated to Japanese ulcerative colitis

AU - Wang, Fangyu

AU - Tahara, Tomomitsu

AU - Arisawa, Tomiyasu

AU - Sakata, Mikijyu

AU - Takahama, Kazuya

AU - Watanabe, Makoto

AU - Hirata, Ichiro

AU - Nakano, Hiroshi

PY - 2008/1/1

Y1 - 2008/1/1

N2 - Background/Aims: Expression of peroxisome proliferator-activated receptor gamma (PPARγ) has been reported to be impaired in patients with ulcerative colitis (UC), and activation of PPARγ is proved to inhibit the intestinal inflammation. As Plo12Ala polymorphism in codon 12 of the PPARγ gene may decrease the promoter activity, we investigated the influences of PPARγ polymorphism on the risk of UC in Japanese population. Methodology: The study recruited 118 patients with UC and 142 health controls. Plo12Ala polymorphisms of PPARγ were detected by polymerase chain reaction based restricted fragment length polymorphism. Results: The frequency of Pro/Alo heterozygotes of PPARγ gene in UC and control group was 4.2% and 4.9%, respectively. No significant difference was found between UC and control group (P=1.00, Fisher's exact test). Plo12Ala genotype of PPARγ did not show significant association with UC risk (OR=0.85, 95%CI=0.26-2.76). Conclusions: Our research suggests that Plo12Ala polymorphism of PPARγ may not be associated with the risk of developing ulcerative colitis in Japanese population.

AB - Background/Aims: Expression of peroxisome proliferator-activated receptor gamma (PPARγ) has been reported to be impaired in patients with ulcerative colitis (UC), and activation of PPARγ is proved to inhibit the intestinal inflammation. As Plo12Ala polymorphism in codon 12 of the PPARγ gene may decrease the promoter activity, we investigated the influences of PPARγ polymorphism on the risk of UC in Japanese population. Methodology: The study recruited 118 patients with UC and 142 health controls. Plo12Ala polymorphisms of PPARγ were detected by polymerase chain reaction based restricted fragment length polymorphism. Results: The frequency of Pro/Alo heterozygotes of PPARγ gene in UC and control group was 4.2% and 4.9%, respectively. No significant difference was found between UC and control group (P=1.00, Fisher's exact test). Plo12Ala genotype of PPARγ did not show significant association with UC risk (OR=0.85, 95%CI=0.26-2.76). Conclusions: Our research suggests that Plo12Ala polymorphism of PPARγ may not be associated with the risk of developing ulcerative colitis in Japanese population.

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