Polymorphism of peroxisome proliferator-activated receptor gamma is not associated to Japanese ulcerative colitis

Fangyu Wang; Tomomitsu Tahara; Tomiyasu Arisawa; Mikijyu Sakata; Kazuya Takahama; Makoto Watanabe; Ichiro Hirata; Hiroshi Nakano

Polymorphism of peroxisome proliferator-activated receptor gamma is not associated to Japanese ulcerative colitis

Fangyu Wang, Tomomitsu Tahara, Tomiyasu Arisawa, Mikijyu Sakata, Kazuya Takahama, Makoto Watanabe, Ichiro Hirata, Hiroshi Nakano

Fujita Health University Hospital

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

Background/Aims: Expression of peroxisome proliferator-activated receptor gamma (PPARγ) has been reported to be impaired in patients with ulcerative colitis (UC), and activation of PPARγ is proved to inhibit the intestinal inflammation. As Plo12Ala polymorphism in codon 12 of the PPARγ gene may decrease the promoter activity, we investigated the influences of PPARγ polymorphism on the risk of UC in Japanese population. Methodology: The study recruited 118 patients with UC and 142 health controls. Plo12Ala polymorphisms of PPARγ were detected by polymerase chain reaction based restricted fragment length polymorphism. Results: The frequency of Pro/Alo heterozygotes of PPARγ gene in UC and control group was 4.2% and 4.9%, respectively. No significant difference was found between UC and control group (P=1.00, Fisher's exact test). Plo12Ala genotype of PPARγ did not show significant association with UC risk (OR=0.85, 95%CI=0.26-2.76). Conclusions: Our research suggests that Plo12Ala polymorphism of PPARγ may not be associated with the risk of developing ulcerative colitis in Japanese population.

Original language	English
Pages (from-to)	73-75
Number of pages	3
Journal	Hepato-gastroenterology
Volume	55
Issue number	81
Publication status	Published - 01-2008

All Science Journal Classification (ASJC) codes

Hepatology
Gastroenterology

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title = "Polymorphism of peroxisome proliferator-activated receptor gamma is not associated to Japanese ulcerative colitis",

abstract = "Background/Aims: Expression of peroxisome proliferator-activated receptor gamma (PPARγ) has been reported to be impaired in patients with ulcerative colitis (UC), and activation of PPARγ is proved to inhibit the intestinal inflammation. As Plo12Ala polymorphism in codon 12 of the PPARγ gene may decrease the promoter activity, we investigated the influences of PPARγ polymorphism on the risk of UC in Japanese population. Methodology: The study recruited 118 patients with UC and 142 health controls. Plo12Ala polymorphisms of PPARγ were detected by polymerase chain reaction based restricted fragment length polymorphism. Results: The frequency of Pro/Alo heterozygotes of PPARγ gene in UC and control group was 4.2% and 4.9%, respectively. No significant difference was found between UC and control group (P=1.00, Fisher's exact test). Plo12Ala genotype of PPARγ did not show significant association with UC risk (OR=0.85, 95%CI=0.26-2.76). Conclusions: Our research suggests that Plo12Ala polymorphism of PPARγ may not be associated with the risk of developing ulcerative colitis in Japanese population.",

author = "Fangyu Wang and Tomomitsu Tahara and Tomiyasu Arisawa and Mikijyu Sakata and Kazuya Takahama and Makoto Watanabe and Ichiro Hirata and Hiroshi Nakano",

year = "2008",

month = jan,

language = "English",

volume = "55",

pages = "73--75",

journal = "Acta hepato-splenologica",

issn = "0172-6390",

publisher = "H.G.E. Update Medical Publishing Ltd.",

number = "81",

}

Polymorphism of peroxisome proliferator-activated receptor gamma is not associated to Japanese ulcerative colitis. / Wang, Fangyu; Tahara, Tomomitsu; Arisawa, Tomiyasu; Sakata, Mikijyu; Takahama, Kazuya; Watanabe, Makoto; Hirata, Ichiro; Nakano, Hiroshi.

In: Hepato-gastroenterology, Vol. 55, No. 81, 01.2008, p. 73-75.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Polymorphism of peroxisome proliferator-activated receptor gamma is not associated to Japanese ulcerative colitis

AU - Wang, Fangyu

AU - Tahara, Tomomitsu

AU - Arisawa, Tomiyasu

AU - Sakata, Mikijyu

AU - Takahama, Kazuya

AU - Watanabe, Makoto

AU - Hirata, Ichiro

AU - Nakano, Hiroshi

PY - 2008/1

Y1 - 2008/1

N2 - Background/Aims: Expression of peroxisome proliferator-activated receptor gamma (PPARγ) has been reported to be impaired in patients with ulcerative colitis (UC), and activation of PPARγ is proved to inhibit the intestinal inflammation. As Plo12Ala polymorphism in codon 12 of the PPARγ gene may decrease the promoter activity, we investigated the influences of PPARγ polymorphism on the risk of UC in Japanese population. Methodology: The study recruited 118 patients with UC and 142 health controls. Plo12Ala polymorphisms of PPARγ were detected by polymerase chain reaction based restricted fragment length polymorphism. Results: The frequency of Pro/Alo heterozygotes of PPARγ gene in UC and control group was 4.2% and 4.9%, respectively. No significant difference was found between UC and control group (P=1.00, Fisher's exact test). Plo12Ala genotype of PPARγ did not show significant association with UC risk (OR=0.85, 95%CI=0.26-2.76). Conclusions: Our research suggests that Plo12Ala polymorphism of PPARγ may not be associated with the risk of developing ulcerative colitis in Japanese population.

AB - Background/Aims: Expression of peroxisome proliferator-activated receptor gamma (PPARγ) has been reported to be impaired in patients with ulcerative colitis (UC), and activation of PPARγ is proved to inhibit the intestinal inflammation. As Plo12Ala polymorphism in codon 12 of the PPARγ gene may decrease the promoter activity, we investigated the influences of PPARγ polymorphism on the risk of UC in Japanese population. Methodology: The study recruited 118 patients with UC and 142 health controls. Plo12Ala polymorphisms of PPARγ were detected by polymerase chain reaction based restricted fragment length polymorphism. Results: The frequency of Pro/Alo heterozygotes of PPARγ gene in UC and control group was 4.2% and 4.9%, respectively. No significant difference was found between UC and control group (P=1.00, Fisher's exact test). Plo12Ala genotype of PPARγ did not show significant association with UC risk (OR=0.85, 95%CI=0.26-2.76). Conclusions: Our research suggests that Plo12Ala polymorphism of PPARγ may not be associated with the risk of developing ulcerative colitis in Japanese population.

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Polymorphism of peroxisome proliferator-activated receptor gamma is not associated to Japanese ulcerative colitis

Abstract

All Science Journal Classification (ASJC) codes

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