Polymorphisms in CYP19A1, HSD17B1 and HSD17B2 genes and serum sex hormone level among postmenopausal Japanese women

Satoyo Hosono, Hidemi Ito, Isao Oze, Yasuki Higaki, Emi Morita, Naoyuki Takashima, Sadao Suzuki, Keiichi Shimatani, Haruo Mikami, Keizo Ohnaka, Etsuko Ozaki, Sakurako Katsuura-Kamano, Michiaki Kubo, Chisato Nagata, Mariko Naito, Nobuyuki Hamajima, Hideo Tanaka

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Objective Extraovarian sex hormone production plays an important role in estrogen biosynthesis in postmenopausal women. We examined possible associations between serum sex hormone level and polymorphisms in CYP19A1, HSD17B1, and HSD17B2. We also assessed possible interaction between these polymorphisms and current overweight. Methods We conducted a cross-sectional study. 785 Japanese natural postmenopausal women were randomly selected from the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study database. Information on lifestyle factors was obtained from a self-administered questionnaire. Serum estrogens and androgens levels were measured by liquid chromatography-tandem mass spectrometry. Four tag SNPs (single nucleotide polymorphisms) of CYP19A1, one missense SNP of HSD17B1 and three tag SNPs of HSD17B2 were examined by Invader assay. A trend test was conducted using linear regression. Results After adjustment for multiple comparisons, we found that rs4441215 and rs936306 in CYP19A1 and rs4888202 and rs2955160 in HSD17B2 were associated with differences in serum estrone level. Further, rs4441215 and rs936306 were associated with differences in serum estradiol level. None of these polymorphisms showed a significant interaction with current body mass index (BMI). Conclusions Our findings suggested that CYP19A1 and HSD17B2 polymorphisms might be associated with circulating sex hormone levels in Japanese postmenopausal women, independent of current BMI.

Original languageEnglish
Pages (from-to)394-401
Number of pages8
JournalMaturitas
Volume82
Issue number4
DOIs
Publication statusPublished - 01-12-2015

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Gonadal Steroid Hormones
Polymorphism
Genes
Single Nucleotide Polymorphism
Serum
Estrogens
Body Mass Index
Nucleotides
Estrone
Tandem Mass Spectrometry
Liquid Chromatography
Androgens
Life Style
Estradiol
Linear Models
Japan
Cohort Studies
Cross-Sectional Studies
Databases
Biosynthesis

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Obstetrics and Gynaecology

Cite this

Hosono, Satoyo ; Ito, Hidemi ; Oze, Isao ; Higaki, Yasuki ; Morita, Emi ; Takashima, Naoyuki ; Suzuki, Sadao ; Shimatani, Keiichi ; Mikami, Haruo ; Ohnaka, Keizo ; Ozaki, Etsuko ; Katsuura-Kamano, Sakurako ; Kubo, Michiaki ; Nagata, Chisato ; Naito, Mariko ; Hamajima, Nobuyuki ; Tanaka, Hideo. / Polymorphisms in CYP19A1, HSD17B1 and HSD17B2 genes and serum sex hormone level among postmenopausal Japanese women. In: Maturitas. 2015 ; Vol. 82, No. 4. pp. 394-401.
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abstract = "Objective Extraovarian sex hormone production plays an important role in estrogen biosynthesis in postmenopausal women. We examined possible associations between serum sex hormone level and polymorphisms in CYP19A1, HSD17B1, and HSD17B2. We also assessed possible interaction between these polymorphisms and current overweight. Methods We conducted a cross-sectional study. 785 Japanese natural postmenopausal women were randomly selected from the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study database. Information on lifestyle factors was obtained from a self-administered questionnaire. Serum estrogens and androgens levels were measured by liquid chromatography-tandem mass spectrometry. Four tag SNPs (single nucleotide polymorphisms) of CYP19A1, one missense SNP of HSD17B1 and three tag SNPs of HSD17B2 were examined by Invader assay. A trend test was conducted using linear regression. Results After adjustment for multiple comparisons, we found that rs4441215 and rs936306 in CYP19A1 and rs4888202 and rs2955160 in HSD17B2 were associated with differences in serum estrone level. Further, rs4441215 and rs936306 were associated with differences in serum estradiol level. None of these polymorphisms showed a significant interaction with current body mass index (BMI). Conclusions Our findings suggested that CYP19A1 and HSD17B2 polymorphisms might be associated with circulating sex hormone levels in Japanese postmenopausal women, independent of current BMI.",
author = "Satoyo Hosono and Hidemi Ito and Isao Oze and Yasuki Higaki and Emi Morita and Naoyuki Takashima and Sadao Suzuki and Keiichi Shimatani and Haruo Mikami and Keizo Ohnaka and Etsuko Ozaki and Sakurako Katsuura-Kamano and Michiaki Kubo and Chisato Nagata and Mariko Naito and Nobuyuki Hamajima and Hideo Tanaka",
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Hosono, S, Ito, H, Oze, I, Higaki, Y, Morita, E, Takashima, N, Suzuki, S, Shimatani, K, Mikami, H, Ohnaka, K, Ozaki, E, Katsuura-Kamano, S, Kubo, M, Nagata, C, Naito, M, Hamajima, N & Tanaka, H 2015, 'Polymorphisms in CYP19A1, HSD17B1 and HSD17B2 genes and serum sex hormone level among postmenopausal Japanese women', Maturitas, vol. 82, no. 4, pp. 394-401. https://doi.org/10.1016/j.maturitas.2015.08.003

Polymorphisms in CYP19A1, HSD17B1 and HSD17B2 genes and serum sex hormone level among postmenopausal Japanese women. / Hosono, Satoyo; Ito, Hidemi; Oze, Isao; Higaki, Yasuki; Morita, Emi; Takashima, Naoyuki; Suzuki, Sadao; Shimatani, Keiichi; Mikami, Haruo; Ohnaka, Keizo; Ozaki, Etsuko; Katsuura-Kamano, Sakurako; Kubo, Michiaki; Nagata, Chisato; Naito, Mariko; Hamajima, Nobuyuki; Tanaka, Hideo.

In: Maturitas, Vol. 82, No. 4, 01.12.2015, p. 394-401.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Polymorphisms in CYP19A1, HSD17B1 and HSD17B2 genes and serum sex hormone level among postmenopausal Japanese women

AU - Hosono, Satoyo

AU - Ito, Hidemi

AU - Oze, Isao

AU - Higaki, Yasuki

AU - Morita, Emi

AU - Takashima, Naoyuki

AU - Suzuki, Sadao

AU - Shimatani, Keiichi

AU - Mikami, Haruo

AU - Ohnaka, Keizo

AU - Ozaki, Etsuko

AU - Katsuura-Kamano, Sakurako

AU - Kubo, Michiaki

AU - Nagata, Chisato

AU - Naito, Mariko

AU - Hamajima, Nobuyuki

AU - Tanaka, Hideo

PY - 2015/12/1

Y1 - 2015/12/1

N2 - Objective Extraovarian sex hormone production plays an important role in estrogen biosynthesis in postmenopausal women. We examined possible associations between serum sex hormone level and polymorphisms in CYP19A1, HSD17B1, and HSD17B2. We also assessed possible interaction between these polymorphisms and current overweight. Methods We conducted a cross-sectional study. 785 Japanese natural postmenopausal women were randomly selected from the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study database. Information on lifestyle factors was obtained from a self-administered questionnaire. Serum estrogens and androgens levels were measured by liquid chromatography-tandem mass spectrometry. Four tag SNPs (single nucleotide polymorphisms) of CYP19A1, one missense SNP of HSD17B1 and three tag SNPs of HSD17B2 were examined by Invader assay. A trend test was conducted using linear regression. Results After adjustment for multiple comparisons, we found that rs4441215 and rs936306 in CYP19A1 and rs4888202 and rs2955160 in HSD17B2 were associated with differences in serum estrone level. Further, rs4441215 and rs936306 were associated with differences in serum estradiol level. None of these polymorphisms showed a significant interaction with current body mass index (BMI). Conclusions Our findings suggested that CYP19A1 and HSD17B2 polymorphisms might be associated with circulating sex hormone levels in Japanese postmenopausal women, independent of current BMI.

AB - Objective Extraovarian sex hormone production plays an important role in estrogen biosynthesis in postmenopausal women. We examined possible associations between serum sex hormone level and polymorphisms in CYP19A1, HSD17B1, and HSD17B2. We also assessed possible interaction between these polymorphisms and current overweight. Methods We conducted a cross-sectional study. 785 Japanese natural postmenopausal women were randomly selected from the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study database. Information on lifestyle factors was obtained from a self-administered questionnaire. Serum estrogens and androgens levels were measured by liquid chromatography-tandem mass spectrometry. Four tag SNPs (single nucleotide polymorphisms) of CYP19A1, one missense SNP of HSD17B1 and three tag SNPs of HSD17B2 were examined by Invader assay. A trend test was conducted using linear regression. Results After adjustment for multiple comparisons, we found that rs4441215 and rs936306 in CYP19A1 and rs4888202 and rs2955160 in HSD17B2 were associated with differences in serum estrone level. Further, rs4441215 and rs936306 were associated with differences in serum estradiol level. None of these polymorphisms showed a significant interaction with current body mass index (BMI). Conclusions Our findings suggested that CYP19A1 and HSD17B2 polymorphisms might be associated with circulating sex hormone levels in Japanese postmenopausal women, independent of current BMI.

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