TY - JOUR
T1 - Polymorphisms in genes encoding antioxidant enzymes (SOD2, CAT, GPx, TXNRD, SEPP1, SEP15 and SELS) and risk of chronic kidney disease in Japanese - Cross-sectional data from the J-MICC study
AU - Hishida, Asahi
AU - Okada, Rieko
AU - Naito, Mariko
AU - Morita, Emi
AU - Wakai, Kenji
AU - Hamajima, Nobuyuki
AU - Hosono, Satoyo
AU - Nanri, Hinako
AU - Turin, Tanvir Chowdhury
AU - Suzuki, Sadao
AU - Kuwabara, Kazuyo
AU - Mikami, Haruo
AU - Budhathoki, Sanjeev
AU - Watanabe, Isao
AU - Arisawa, Kokichi
AU - Kubo, Michiaki
AU - Tanaka, Hideo
N1 - Funding Information:
B. K. P acknowledges the support of this research by the Department of Science and Technology (DST), New Delhi (SB/S1/OC-53/2013), and the Council of Scientific and Industrial Research (CSIR), New Delhi [02(0096)/12/EMR-II]. N. K., S. K. S. and A. B. thank CSIR for fellowships.
PY - 2013/8/1
Y1 - 2013/8/1
N2 - Chronic kidney disease (CKD) is well known as a strong risk factor for both of end-stage renal disease and cardiovascular disease. To clarify the association of polymorphisms in the genes encoding antioxidant enzymes (SOD2, CAT, GPx, TXNRD. SEPP1, SEP15 and SELS) with the risk of CKD in Japanese, we examined this association using the cross-sectional data of Japan Multi-Institutional Collaborative Cohort (J-MICC) Study. The subjects were 3,285 men and women, aged 35-69 years, selected from J-MICC Study participants for whom genotyping were conducted by multiplex polymerase chain reaction-based Invader assay. The prevalence of CKD was determined for CKD stages 3-5 (eGFR <60 ml/min/1.73 m2). When those with CATC-262T C/C were defined as reference, those with CAT C-262T C/T demonstrated the OR for CKD of 0.67 (95% CI 0.43-1.06) with the marginally significant trend for decreased odds ratio with increasing numbers of T allele (p = 0.070). There were no significant associations between the other polymorphisms with CKD risk. The present study found a marginally significant trend of the decreased risk of CKD with increasing numbers of T allele of CAT, which may suggest the possibility of personalized risk estimation of this life-limiting disease in the near future.
AB - Chronic kidney disease (CKD) is well known as a strong risk factor for both of end-stage renal disease and cardiovascular disease. To clarify the association of polymorphisms in the genes encoding antioxidant enzymes (SOD2, CAT, GPx, TXNRD. SEPP1, SEP15 and SELS) with the risk of CKD in Japanese, we examined this association using the cross-sectional data of Japan Multi-Institutional Collaborative Cohort (J-MICC) Study. The subjects were 3,285 men and women, aged 35-69 years, selected from J-MICC Study participants for whom genotyping were conducted by multiplex polymerase chain reaction-based Invader assay. The prevalence of CKD was determined for CKD stages 3-5 (eGFR <60 ml/min/1.73 m2). When those with CATC-262T C/C were defined as reference, those with CAT C-262T C/T demonstrated the OR for CKD of 0.67 (95% CI 0.43-1.06) with the marginally significant trend for decreased odds ratio with increasing numbers of T allele (p = 0.070). There were no significant associations between the other polymorphisms with CKD risk. The present study found a marginally significant trend of the decreased risk of CKD with increasing numbers of T allele of CAT, which may suggest the possibility of personalized risk estimation of this life-limiting disease in the near future.
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U2 - 10.3164/jcbn.13-17
DO - 10.3164/jcbn.13-17
M3 - Article
C2 - 23874065
AN - SCOPUS:84881307412
SN - 0912-0009
VL - 53
SP - 15
EP - 20
JO - Journal of Clinical Biochemistry and Nutrition
JF - Journal of Clinical Biochemistry and Nutrition
IS - 1
ER -
