Polymorphisms in genes encoding antioxidant enzymes (SOD2, CAT, GPx, TXNRD, SEPP1, SEP15 and SELS) and risk of chronic kidney disease in Japanese - Cross-sectional data from the J-MICC study

Asahi Hishida, Rieko Okada, Mariko Naito, Emi Morita, Kenji Wakai, Nobuyuki Hamajima, Satoyo Hosono, Hinako Nanri, Tanvir Chowdhury Turin, Sadao Suzuki, Kazuyo Kuwabara, Haruo Mikami, Sanjeev Budhathoki, Isao Watanabe, Kokichi Arisawa, Michiaki Kubo, Hideo Tanaka

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6 Citations (Scopus)

Abstract

Chronic kidney disease (CKD) is well known as a strong risk factor for both of end-stage renal disease and cardiovascular disease. To clarify the association of polymorphisms in the genes encoding antioxidant enzymes (SOD2, CAT, GPx, TXNRD. SEPP1, SEP15 and SELS) with the risk of CKD in Japanese, we examined this association using the cross-sectional data of Japan Multi-Institutional Collaborative Cohort (J-MICC) Study. The subjects were 3,285 men and women, aged 35-69 years, selected from J-MICC Study participants for whom genotyping were conducted by multiplex polymerase chain reaction-based Invader assay. The prevalence of CKD was determined for CKD stages 3-5 (eGFR <60 ml/min/1.73 m2). When those with CATC-262T C/C were defined as reference, those with CAT C-262T C/T demonstrated the OR for CKD of 0.67 (95% CI 0.43-1.06) with the marginally significant trend for decreased odds ratio with increasing numbers of T allele (p = 0.070). There were no significant associations between the other polymorphisms with CKD risk. The present study found a marginally significant trend of the decreased risk of CKD with increasing numbers of T allele of CAT, which may suggest the possibility of personalized risk estimation of this life-limiting disease in the near future.

Original languageEnglish
Pages (from-to)15-20
Number of pages6
JournalJournal of Clinical Biochemistry and Nutrition
Volume53
Issue number1
DOIs
Publication statusPublished - 01-08-2013

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All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Clinical Biochemistry

Cite this

Hishida, A., Okada, R., Naito, M., Morita, E., Wakai, K., Hamajima, N., Hosono, S., Nanri, H., Turin, T. C., Suzuki, S., Kuwabara, K., Mikami, H., Budhathoki, S., Watanabe, I., Arisawa, K., Kubo, M., & Tanaka, H. (2013). Polymorphisms in genes encoding antioxidant enzymes (SOD2, CAT, GPx, TXNRD, SEPP1, SEP15 and SELS) and risk of chronic kidney disease in Japanese - Cross-sectional data from the J-MICC study. Journal of Clinical Biochemistry and Nutrition, 53(1), 15-20. https://doi.org/10.3164/jcbn.13-17