Polymorphisms in PPAR genes (PPARD, PPARG, and PPARGC1A) and the risk of chronic kidney disease in Japanese: Cross-sectional data from the J-MICC study

Asahi Hishida, Kenji Wakai, Mariko Naito, Takashi Tamura, Sayo Kawai, Nobuyuki Hamajima, Isao Oze, Takeshi Imaizumi, Tanvir Chowdhury Turin, Sadao Suzuki, Motahare Kheradmand, Haruo Mikami, Keizo Ohnaka, Yoshiyuki Watanabe, Kokichi Arisawa, Michiaki Kubo, Hideo Tanaka

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3 Citations (Scopus)

Abstract

Chronic kidney disease (CKD) is well known as a strong risk factor for both end stage renal disease and cardiovascular disease. To clarify the association of polymorphisms in the PPAR genes (PPARD, PPARG, and PPARGC1A) with the risk of CKD in Japanese, we examined this association among the Japanese subjects using the cross-sectional data of J-MICC (Japan Multi-Institutional Collaborative Cohort) Study. The subjects for this analysis were 3,285 men and women, aged 35-69 years, selected from J-MICC Study participants; genotyping was conducted by multiplex polymerase chain reaction-based Invader assay. The prevalence of CKD was determined for CKD stages 3-5 (defined as eGFR < 60 ml/min/1.73 m2). Participants with CKD accounted for 17.3% of the study population. When those with PPARD T-842C T/T were defined as reference, those with PPARD T-842C T/C and C/C demonstrated the OR for CKD of 1.26 (95%CI 1.04-1.53) and 1.31 (95%CI 0.83-2.06), respectively. There were no significant associations between the polymorphisms in other PPAR genes and the risk of CKD. The present study found a significantly increased risk of CKD in those with the C allele of PPARD T-842C, which may suggest the possibility of personalized risk estimation of this life-limiting disease in the near future.

Original languageEnglish
Article number980471
JournalPPAR Research
DOIs
Publication statusPublished - 06-12-2013

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Peroxisome Proliferator-Activated Receptors
Chronic Renal Insufficiency
Japan
Cohort Studies
Genes
Multiplex Polymerase Chain Reaction
Chronic Kidney Failure
Cardiovascular Diseases
Alleles

All Science Journal Classification (ASJC) codes

  • Drug Discovery
  • Pharmacology (medical)

Cite this

Hishida, Asahi ; Wakai, Kenji ; Naito, Mariko ; Tamura, Takashi ; Kawai, Sayo ; Hamajima, Nobuyuki ; Oze, Isao ; Imaizumi, Takeshi ; Turin, Tanvir Chowdhury ; Suzuki, Sadao ; Kheradmand, Motahare ; Mikami, Haruo ; Ohnaka, Keizo ; Watanabe, Yoshiyuki ; Arisawa, Kokichi ; Kubo, Michiaki ; Tanaka, Hideo. / Polymorphisms in PPAR genes (PPARD, PPARG, and PPARGC1A) and the risk of chronic kidney disease in Japanese : Cross-sectional data from the J-MICC study. In: PPAR Research. 2013.
@article{dd26ac69c12e40f2b57aff679b62a84f,
title = "Polymorphisms in PPAR genes (PPARD, PPARG, and PPARGC1A) and the risk of chronic kidney disease in Japanese: Cross-sectional data from the J-MICC study",
abstract = "Chronic kidney disease (CKD) is well known as a strong risk factor for both end stage renal disease and cardiovascular disease. To clarify the association of polymorphisms in the PPAR genes (PPARD, PPARG, and PPARGC1A) with the risk of CKD in Japanese, we examined this association among the Japanese subjects using the cross-sectional data of J-MICC (Japan Multi-Institutional Collaborative Cohort) Study. The subjects for this analysis were 3,285 men and women, aged 35-69 years, selected from J-MICC Study participants; genotyping was conducted by multiplex polymerase chain reaction-based Invader assay. The prevalence of CKD was determined for CKD stages 3-5 (defined as eGFR < 60 ml/min/1.73 m2). Participants with CKD accounted for 17.3{\%} of the study population. When those with PPARD T-842C T/T were defined as reference, those with PPARD T-842C T/C and C/C demonstrated the OR for CKD of 1.26 (95{\%}CI 1.04-1.53) and 1.31 (95{\%}CI 0.83-2.06), respectively. There were no significant associations between the polymorphisms in other PPAR genes and the risk of CKD. The present study found a significantly increased risk of CKD in those with the C allele of PPARD T-842C, which may suggest the possibility of personalized risk estimation of this life-limiting disease in the near future.",
author = "Asahi Hishida and Kenji Wakai and Mariko Naito and Takashi Tamura and Sayo Kawai and Nobuyuki Hamajima and Isao Oze and Takeshi Imaizumi and Turin, {Tanvir Chowdhury} and Sadao Suzuki and Motahare Kheradmand and Haruo Mikami and Keizo Ohnaka and Yoshiyuki Watanabe and Kokichi Arisawa and Michiaki Kubo and Hideo Tanaka",
year = "2013",
month = "12",
day = "6",
doi = "10.1155/2013/980471",
language = "English",
journal = "PPAR Research",
issn = "1687-4757",
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Hishida, A, Wakai, K, Naito, M, Tamura, T, Kawai, S, Hamajima, N, Oze, I, Imaizumi, T, Turin, TC, Suzuki, S, Kheradmand, M, Mikami, H, Ohnaka, K, Watanabe, Y, Arisawa, K, Kubo, M & Tanaka, H 2013, 'Polymorphisms in PPAR genes (PPARD, PPARG, and PPARGC1A) and the risk of chronic kidney disease in Japanese: Cross-sectional data from the J-MICC study', PPAR Research. https://doi.org/10.1155/2013/980471

Polymorphisms in PPAR genes (PPARD, PPARG, and PPARGC1A) and the risk of chronic kidney disease in Japanese : Cross-sectional data from the J-MICC study. / Hishida, Asahi; Wakai, Kenji; Naito, Mariko; Tamura, Takashi; Kawai, Sayo; Hamajima, Nobuyuki; Oze, Isao; Imaizumi, Takeshi; Turin, Tanvir Chowdhury; Suzuki, Sadao; Kheradmand, Motahare; Mikami, Haruo; Ohnaka, Keizo; Watanabe, Yoshiyuki; Arisawa, Kokichi; Kubo, Michiaki; Tanaka, Hideo.

In: PPAR Research, 06.12.2013.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Polymorphisms in PPAR genes (PPARD, PPARG, and PPARGC1A) and the risk of chronic kidney disease in Japanese

T2 - Cross-sectional data from the J-MICC study

AU - Hishida, Asahi

AU - Wakai, Kenji

AU - Naito, Mariko

AU - Tamura, Takashi

AU - Kawai, Sayo

AU - Hamajima, Nobuyuki

AU - Oze, Isao

AU - Imaizumi, Takeshi

AU - Turin, Tanvir Chowdhury

AU - Suzuki, Sadao

AU - Kheradmand, Motahare

AU - Mikami, Haruo

AU - Ohnaka, Keizo

AU - Watanabe, Yoshiyuki

AU - Arisawa, Kokichi

AU - Kubo, Michiaki

AU - Tanaka, Hideo

PY - 2013/12/6

Y1 - 2013/12/6

N2 - Chronic kidney disease (CKD) is well known as a strong risk factor for both end stage renal disease and cardiovascular disease. To clarify the association of polymorphisms in the PPAR genes (PPARD, PPARG, and PPARGC1A) with the risk of CKD in Japanese, we examined this association among the Japanese subjects using the cross-sectional data of J-MICC (Japan Multi-Institutional Collaborative Cohort) Study. The subjects for this analysis were 3,285 men and women, aged 35-69 years, selected from J-MICC Study participants; genotyping was conducted by multiplex polymerase chain reaction-based Invader assay. The prevalence of CKD was determined for CKD stages 3-5 (defined as eGFR < 60 ml/min/1.73 m2). Participants with CKD accounted for 17.3% of the study population. When those with PPARD T-842C T/T were defined as reference, those with PPARD T-842C T/C and C/C demonstrated the OR for CKD of 1.26 (95%CI 1.04-1.53) and 1.31 (95%CI 0.83-2.06), respectively. There were no significant associations between the polymorphisms in other PPAR genes and the risk of CKD. The present study found a significantly increased risk of CKD in those with the C allele of PPARD T-842C, which may suggest the possibility of personalized risk estimation of this life-limiting disease in the near future.

AB - Chronic kidney disease (CKD) is well known as a strong risk factor for both end stage renal disease and cardiovascular disease. To clarify the association of polymorphisms in the PPAR genes (PPARD, PPARG, and PPARGC1A) with the risk of CKD in Japanese, we examined this association among the Japanese subjects using the cross-sectional data of J-MICC (Japan Multi-Institutional Collaborative Cohort) Study. The subjects for this analysis were 3,285 men and women, aged 35-69 years, selected from J-MICC Study participants; genotyping was conducted by multiplex polymerase chain reaction-based Invader assay. The prevalence of CKD was determined for CKD stages 3-5 (defined as eGFR < 60 ml/min/1.73 m2). Participants with CKD accounted for 17.3% of the study population. When those with PPARD T-842C T/T were defined as reference, those with PPARD T-842C T/C and C/C demonstrated the OR for CKD of 1.26 (95%CI 1.04-1.53) and 1.31 (95%CI 0.83-2.06), respectively. There were no significant associations between the polymorphisms in other PPAR genes and the risk of CKD. The present study found a significantly increased risk of CKD in those with the C allele of PPARD T-842C, which may suggest the possibility of personalized risk estimation of this life-limiting disease in the near future.

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