Polymorphisms related to SIRS and inflammatory response

Toshihiko Mayumi, Takuro Arishima, Hideo Takahashi, Jun Takezawa

Research output: Contribution to journalReview articlepeer-review

3 Citations (Scopus)


Recently, susceptibility and outcome of disease are proved to depend on some gene polymorphisms. Here, we review of gene polymorphisms and its contributions to systemic inflammatory response syndrome (SIRS) and inflammation. The relationships of many polymorphisms, such as TNF, IL-1, PAI-1, TLR, etc. and infections have been studied. Gene polymorphisms of some cytokines are reported to increase expression and production of these cytokines, prevalence rate, morbidity and mortality. These polymorphism informations will be very useful for the prevention and therapy in infected diseases, and recognition of patients that need intensive therapy. From analysis of each patient's gene polymorphism, therapy will be changed case by case. Judging from the difference of races and polymorphisms, Japanese need multi-center large scaled studies in Japan.

Original languageEnglish
Pages (from-to)2221-2228
Number of pages8
JournalNippon rinsho. Japanese journal of clinical medicine
Issue number12
Publication statusPublished - 12-2004
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Medicine(all)


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