Population-based prospective study of the combined influence of cigarette smoking and Helicobacter pylori infection on gastric cancer incidence

The Hisayama study

Kentaro Shikata, Yasufumi Doi, Koji Yonemoto, Hisatomi Arima, Toshiharu Ninomiya, Michiaki Kubo, Yumihiro Tanizaki, Takayuki Matsumoto, Mitsuo Iida, Yutaka Kiyohara

Research output: Contribution to journalArticle

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Abstract

The authors assessed the separate and joint influences of cigarette smoking and Helicobacter pylori infection on the development of gastric cancer in a population-based prospective study. A total of 1,071 Japanese men aged ≥40 years were followed up prospectively for 14 years (1998-2002). Compared with that for current nonsmokers, the multivariate-adjusted hazard ratios of gastric cancer for smokers of 1-9, 10-19, and ≥20 cigarettes per day were 1.36 (95% confidence interval (CI): 0.50, 3.71), 1.93 (95% CI: 1.01, 3.67), and 1.88 (95% CI: 1.02, 3.43), respectively. The risk of gastric cancer increased steeply for subjects who had both a smoking habit and H. pylori infection compared with those who did not have both risk factors (hazard ratio = 11.41, 95% CI: 1.54, 84.67). If causal, the estimated population attributable fraction of gastric cancer for cigarette smoking was approximately half that for H. pylori infection (28.4% vs. 56.2%). The overlap of the population attributable fractions for the 2 factors was 49.6%. Findings suggest that cigarette smoking and H. pylori infection are significant risk factors for gastric cancer in Japanese men, and the magnitude of their combined influence is considerable.

Original languageEnglish
Pages (from-to)1409-1415
Number of pages7
JournalAmerican Journal of Epidemiology
Volume168
Issue number12
DOIs
Publication statusPublished - 01-12-2008
Externally publishedYes

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Helicobacter Infections
Helicobacter pylori
Stomach Neoplasms
Smoking
Prospective Studies
Confidence Intervals
Incidence
Population
Tobacco Products
Habits
Joints

All Science Journal Classification (ASJC) codes

  • Epidemiology

Cite this

Shikata, Kentaro ; Doi, Yasufumi ; Yonemoto, Koji ; Arima, Hisatomi ; Ninomiya, Toshiharu ; Kubo, Michiaki ; Tanizaki, Yumihiro ; Matsumoto, Takayuki ; Iida, Mitsuo ; Kiyohara, Yutaka. / Population-based prospective study of the combined influence of cigarette smoking and Helicobacter pylori infection on gastric cancer incidence : The Hisayama study. In: American Journal of Epidemiology. 2008 ; Vol. 168, No. 12. pp. 1409-1415.
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Population-based prospective study of the combined influence of cigarette smoking and Helicobacter pylori infection on gastric cancer incidence : The Hisayama study. / Shikata, Kentaro; Doi, Yasufumi; Yonemoto, Koji; Arima, Hisatomi; Ninomiya, Toshiharu; Kubo, Michiaki; Tanizaki, Yumihiro; Matsumoto, Takayuki; Iida, Mitsuo; Kiyohara, Yutaka.

In: American Journal of Epidemiology, Vol. 168, No. 12, 01.12.2008, p. 1409-1415.

Research output: Contribution to journalArticle

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T2 - The Hisayama study

AU - Shikata, Kentaro

AU - Doi, Yasufumi

AU - Yonemoto, Koji

AU - Arima, Hisatomi

AU - Ninomiya, Toshiharu

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AU - Iida, Mitsuo

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