Population pharmacokinetic analysis of vancomycin in patients with gram-positive infections and the influence of infectious disease type

M. Yamamoto, T. Kuzuya, H. Baba, K. Yamada, T. Nabeshima

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Abstract

Objective: To describe the population pharmacokinetics of vancomycin in patients with gram-positive infections and to investigate the influence of type of infectious disease. Methods: A two-compartment open model was adopted as a pharmacokinetic model. The nonlinear mixed-effects model was used to analyze the population pharmacokinetic models. Results: We propose one general model and one infectious disease type-specific model. The general model showed that vancomycin clearance (CL) was linearly correlated with estimated creatinine clearance (CLCR) when CLCR was less than 85 mL/min, as expressed by CL(L/h) = 0·0322 × CLCR + 0·32. The distribution volumes of the central and peripheral compartment were different in healthy volunteers and patients with gram-positive infections. The infectious disease type-specific model showed that these differences were more pronounced in patients with pneumonia. Conclusion: The population pharmacokinetic parameters of vancomycin obtained here can be used to individualize the dosage of vancomycin in institutions with similar patient population characteristics.

Original languageEnglish
Pages (from-to)473-483
Number of pages11
JournalJournal of Clinical Pharmacy and Therapeutics
Volume34
Issue number4
DOIs
Publication statusPublished - 01-08-2009
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)

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