TY - JOUR
T1 - Positive association of AKT1 haplotype to Japanese methamphetamine use disorder
AU - Ikeda, Masashi
AU - Iwata, Nakao
AU - Suzuki, Tatsuyo
AU - Kitajima, Tsuyoshi
AU - Yamanouchi, Yoshio
AU - Kinoshiya, Yoko
AU - Sekine, Yoshimoto
AU - Iyo, Masaomi
AU - Harano, Mutsuo
AU - Komiyama, Tokutaro
AU - Yamada, Mitsuhiko
AU - Sora, Ichiro
AU - Ujike, Hiroshi
AU - Inada, Toshiya
AU - Ozaki, Norio
PY - 2006/2
Y1 - 2006/2
N2 - Recent evidence suggests that the AKT1-GSK3β signalling cascade partially mediates dopamine-dependent behaviours. In relation to the pathophysiology of schizophrenia or methamphetamine (Meth) use disorder, AKT1 is a good candidate gene for such conditions. For schizophrenia, positive associations of SNPs and AKT1 haplotypes were reported in US and Japanese samples. To evaluate the association between AKT1 and Meth-use disorder, we conducted a case-control study of Japanese samples (182 patients and 437 controls). A positive association between a SNP and haplotypes was found, and the 'signal' SNP was the same SNP found to be associated with US schizophrenia, but not with Japanese schizophrenia. Our results indicate that AKT1 may play a possible role in the development of Meth-use disorder. Further investigation of these associations, together with evidence from previous animal studies, may open the way to elucidation of the pathophysiology of this condition.
AB - Recent evidence suggests that the AKT1-GSK3β signalling cascade partially mediates dopamine-dependent behaviours. In relation to the pathophysiology of schizophrenia or methamphetamine (Meth) use disorder, AKT1 is a good candidate gene for such conditions. For schizophrenia, positive associations of SNPs and AKT1 haplotypes were reported in US and Japanese samples. To evaluate the association between AKT1 and Meth-use disorder, we conducted a case-control study of Japanese samples (182 patients and 437 controls). A positive association between a SNP and haplotypes was found, and the 'signal' SNP was the same SNP found to be associated with US schizophrenia, but not with Japanese schizophrenia. Our results indicate that AKT1 may play a possible role in the development of Meth-use disorder. Further investigation of these associations, together with evidence from previous animal studies, may open the way to elucidation of the pathophysiology of this condition.
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U2 - 10.1017/S1461145705005481
DO - 10.1017/S1461145705005481
M3 - Article
C2 - 15982448
AN - SCOPUS:30344446312
SN - 1461-1457
VL - 9
SP - 77
EP - 81
JO - International Journal of Neuropsychopharmacology
JF - International Journal of Neuropsychopharmacology
IS - 1
ER -
