TY - JOUR
T1 - Positive association of the serotonin 5-HT7 receptor gene with schizophrenia in a Japanese population
AU - Ikeda, Masashi
AU - Iwata, Nakao
AU - Kitajima, Tsuyoshi
AU - Suzuki, Tatsuyo
AU - Yamanouchi, Yoshio
AU - Kinoshita, Yoko
AU - Ozaki, Norio
N1 - Funding Information:
We thank Ms M Miyata and Ms S Nakaguchi for their technical support. This work was supported in part by research grants from the Ministry of Education, Culture, Sports, Science and Technology, the Ministry of Health, Labor and Welfare, and the Japan Health Sciences Foundation (Research on Health Sciences focusing on Drug Innovation).
PY - 2006/4
Y1 - 2006/4
N2 - Several lines of evidence suggest that abnormalities in the serotonin system may be related to the pathophysiology of schizophrenia. The 5-HT 7 receptor is considered to be a possible schizophrenia- susceptibility factor, based on findings from binding, animal, postmortem, and genomewide linkage studies. In this study, we conducted linkage disequilibrium (LD) mapping of the human 5-HT7 receptor gene (HTR7) and selected four 'haplotype-tagging (ht) SNPs'. Using these four htSNPs, we then conducted an LD case-control association analysis in 383 Japanese schizophrenia patients and 351 controls. Two htSNPs (SNP2 and SNP5) and haplotypes were found to be associated with schizophrenia. A promoter SNP (SNP2) was further assessed in a dual-luciferase reporter assay, but it was not found to have any functional relevance. Although we failed to find an actual susceptibility variant that could modify the function of HTR7, our results support the supposition that HTR7 is a susceptibility gene for schizophrenia in this ethnic group.
AB - Several lines of evidence suggest that abnormalities in the serotonin system may be related to the pathophysiology of schizophrenia. The 5-HT 7 receptor is considered to be a possible schizophrenia- susceptibility factor, based on findings from binding, animal, postmortem, and genomewide linkage studies. In this study, we conducted linkage disequilibrium (LD) mapping of the human 5-HT7 receptor gene (HTR7) and selected four 'haplotype-tagging (ht) SNPs'. Using these four htSNPs, we then conducted an LD case-control association analysis in 383 Japanese schizophrenia patients and 351 controls. Two htSNPs (SNP2 and SNP5) and haplotypes were found to be associated with schizophrenia. A promoter SNP (SNP2) was further assessed in a dual-luciferase reporter assay, but it was not found to have any functional relevance. Although we failed to find an actual susceptibility variant that could modify the function of HTR7, our results support the supposition that HTR7 is a susceptibility gene for schizophrenia in this ethnic group.
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U2 - 10.1038/sj.npp.1300901
DO - 10.1038/sj.npp.1300901
M3 - Article
C2 - 16192982
AN - SCOPUS:33645031288
SN - 0893-133X
VL - 31
SP - 866
EP - 871
JO - Neuropsychopharmacology
JF - Neuropsychopharmacology
IS - 4
ER -
