Possible association between the pituitary adenylate cyclase-activating polypeptide (PACAP) gene and major depressive disorder

Ryota Hashimoto, Hitoshi Hashimoto, Norihito Shintani, Kazutaka Ohi, Hiroaki Hori, Osamu Saitoh, Asako Kosuga, Masahiko Tatsumi, Nakao Iwata, Norio Ozaki, Kunitoshi Kamijima, Akemichi Baba, Masatoshi Takeda, Hiroshi Kunugi

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34 Citations (Scopus)

Abstract

Pituitary adenylate cyclase-activating polypeptide (PACAP, ADCYAP1: adenylate cyclase-activating polypeptide 1) is a neuropeptide with neurotransmission modulating activity. The associations of the PACAP gene with schizophrenia and hippocampal volume have been reported. We recently reported depression-like behavior in the forced swimming test in PACAP deficient mice. Here we examined a possible association between the PACAP gene and major depressive disorder (MDD) in 637 patients and 967 controls and found that a genetic variant in the gene was associated with MDD. The present results suggest that PACAP signaling might contribute to the pathogenesis of MDD.

Original languageEnglish
Pages (from-to)300-302
Number of pages3
JournalNeuroscience Letters
Volume468
Issue number3
DOIs
Publication statusPublished - 14-01-2010

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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    Hashimoto, R., Hashimoto, H., Shintani, N., Ohi, K., Hori, H., Saitoh, O., Kosuga, A., Tatsumi, M., Iwata, N., Ozaki, N., Kamijima, K., Baba, A., Takeda, M., & Kunugi, H. (2010). Possible association between the pituitary adenylate cyclase-activating polypeptide (PACAP) gene and major depressive disorder. Neuroscience Letters, 468(3), 300-302. https://doi.org/10.1016/j.neulet.2009.11.019