Possible association between the pituitary adenylate cyclase-activating polypeptide (PACAP) gene and major depressive disorder

Ryota Hashimoto, Hitoshi Hashimoto, Norihito Shintani, Kazutaka Ohi, Hiroaki Hori, Osamu Saitoh, Asako Kosuga, Masahiko Tatsumi, Nakao Iwata, Norio Ozaki, Kunitoshi Kamijima, Akemichi Baba, Masatoshi Takeda, Hiroshi Kunugi

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Pituitary adenylate cyclase-activating polypeptide (PACAP, ADCYAP1: adenylate cyclase-activating polypeptide 1) is a neuropeptide with neurotransmission modulating activity. The associations of the PACAP gene with schizophrenia and hippocampal volume have been reported. We recently reported depression-like behavior in the forced swimming test in PACAP deficient mice. Here we examined a possible association between the PACAP gene and major depressive disorder (MDD) in 637 patients and 967 controls and found that a genetic variant in the gene was associated with MDD. The present results suggest that PACAP signaling might contribute to the pathogenesis of MDD.

Original languageEnglish
Pages (from-to)300-302
Number of pages3
JournalNeuroscience Letters
Volume468
Issue number3
DOIs
Publication statusPublished - 14-01-2010

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Pituitary Adenylate Cyclase-Activating Polypeptide
Major Depressive Disorder
Genes
Neuropeptides
Adenylyl Cyclases
Synaptic Transmission
Schizophrenia
Depression
Peptides

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Hashimoto, Ryota ; Hashimoto, Hitoshi ; Shintani, Norihito ; Ohi, Kazutaka ; Hori, Hiroaki ; Saitoh, Osamu ; Kosuga, Asako ; Tatsumi, Masahiko ; Iwata, Nakao ; Ozaki, Norio ; Kamijima, Kunitoshi ; Baba, Akemichi ; Takeda, Masatoshi ; Kunugi, Hiroshi. / Possible association between the pituitary adenylate cyclase-activating polypeptide (PACAP) gene and major depressive disorder. In: Neuroscience Letters. 2010 ; Vol. 468, No. 3. pp. 300-302.
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author = "Ryota Hashimoto and Hitoshi Hashimoto and Norihito Shintani and Kazutaka Ohi and Hiroaki Hori and Osamu Saitoh and Asako Kosuga and Masahiko Tatsumi and Nakao Iwata and Norio Ozaki and Kunitoshi Kamijima and Akemichi Baba and Masatoshi Takeda and Hiroshi Kunugi",
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Hashimoto, R, Hashimoto, H, Shintani, N, Ohi, K, Hori, H, Saitoh, O, Kosuga, A, Tatsumi, M, Iwata, N, Ozaki, N, Kamijima, K, Baba, A, Takeda, M & Kunugi, H 2010, 'Possible association between the pituitary adenylate cyclase-activating polypeptide (PACAP) gene and major depressive disorder', Neuroscience Letters, vol. 468, no. 3, pp. 300-302. https://doi.org/10.1016/j.neulet.2009.11.019

Possible association between the pituitary adenylate cyclase-activating polypeptide (PACAP) gene and major depressive disorder. / Hashimoto, Ryota; Hashimoto, Hitoshi; Shintani, Norihito; Ohi, Kazutaka; Hori, Hiroaki; Saitoh, Osamu; Kosuga, Asako; Tatsumi, Masahiko; Iwata, Nakao; Ozaki, Norio; Kamijima, Kunitoshi; Baba, Akemichi; Takeda, Masatoshi; Kunugi, Hiroshi.

In: Neuroscience Letters, Vol. 468, No. 3, 14.01.2010, p. 300-302.

Research output: Contribution to journalArticle

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AU - Hashimoto, Ryota

AU - Hashimoto, Hitoshi

AU - Shintani, Norihito

AU - Ohi, Kazutaka

AU - Hori, Hiroaki

AU - Saitoh, Osamu

AU - Kosuga, Asako

AU - Tatsumi, Masahiko

AU - Iwata, Nakao

AU - Ozaki, Norio

AU - Kamijima, Kunitoshi

AU - Baba, Akemichi

AU - Takeda, Masatoshi

AU - Kunugi, Hiroshi

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