@article{1f7fcea3d5f949d987762c06b9ab131d,
title = "Possible association between the pituitary adenylate cyclase-activating polypeptide (PACAP) gene and major depressive disorder",
abstract = "Pituitary adenylate cyclase-activating polypeptide (PACAP, ADCYAP1: adenylate cyclase-activating polypeptide 1) is a neuropeptide with neurotransmission modulating activity. The associations of the PACAP gene with schizophrenia and hippocampal volume have been reported. We recently reported depression-like behavior in the forced swimming test in PACAP deficient mice. Here we examined a possible association between the PACAP gene and major depressive disorder (MDD) in 637 patients and 967 controls and found that a genetic variant in the gene was associated with MDD. The present results suggest that PACAP signaling might contribute to the pathogenesis of MDD.",
keywords = "ADCYAP1, Depression, Major depressive disorder, PACAP, Single nucleotide polymorphism",
author = "Ryota Hashimoto and Hitoshi Hashimoto and Norihito Shintani and Kazutaka Ohi and Hiroaki Hori and Osamu Saitoh and Asako Kosuga and Masahiko Tatsumi and Nakao Iwata and Norio Ozaki and Kunitoshi Kamijima and Akemichi Baba and Masatoshi Takeda and Hiroshi Kunugi",
note = "Funding Information: This work was supported in part by Grants-in-Aid from the Japanese Ministry of Health, Labor and Welfare (H18-kokoro-005, H19-kokoro-002), the Japanese Ministry of Education, Culture, Sports, Science and Technology (18689030), CREST of JST, Grant-aid for Scientific Research on Priority Areas – Research on Pathomechanisms of Brain Disorders – from the MEXT (18023045) and Japan Foundation for Neuroscience and Mental Health.",
year = "2010",
month = jan,
day = "14",
doi = "10.1016/j.neulet.2009.11.019",
language = "English",
volume = "468",
pages = "300--302",
journal = "Neuroscience Letters",
issn = "0304-3940",
publisher = "Elsevier Ireland Ltd",
number = "3",
}