Possible association between the pituitary adenylate cyclase-activating polypeptide (PACAP) gene and major depressive disorder

Ryota Hashimoto; Hitoshi Hashimoto; Norihito Shintani; Kazutaka Ohi; Hiroaki Hori; Osamu Saitoh; Asako Kosuga; Masahiko Tatsumi; Nakao Iwata; Norio Ozaki; Kunitoshi Kamijima; Akemichi Baba; Masatoshi Takeda; Hiroshi Kunugi

doi:10.1016/j.neulet.2009.11.019

Possible association between the pituitary adenylate cyclase-activating polypeptide (PACAP) gene and major depressive disorder

Ryota Hashimoto
, Hitoshi Hashimoto
, Norihito Shintani
, Kazutaka Ohi
, Hiroaki Hori
, Osamu Saitoh
, Asako Kosuga
, Masahiko Tatsumi
, Nakao Iwata
, Norio Ozaki
, Kunitoshi Kamijima
, Akemichi Baba
, Masatoshi Takeda
, Hiroshi Kunugi

Research output: Contribution to journal › Article › peer-review

58 Citations (Scopus)

Abstract

Pituitary adenylate cyclase-activating polypeptide (PACAP, ADCYAP1: adenylate cyclase-activating polypeptide 1) is a neuropeptide with neurotransmission modulating activity. The associations of the PACAP gene with schizophrenia and hippocampal volume have been reported. We recently reported depression-like behavior in the forced swimming test in PACAP deficient mice. Here we examined a possible association between the PACAP gene and major depressive disorder (MDD) in 637 patients and 967 controls and found that a genetic variant in the gene was associated with MDD. The present results suggest that PACAP signaling might contribute to the pathogenesis of MDD.

Original language	English
Pages (from-to)	300-302
Number of pages	3
Journal	Neuroscience Letters
Volume	468
Issue number	3
DOIs	https://doi.org/10.1016/j.neulet.2009.11.019
Publication status	Published - 14-01-2010
Externally published	Yes

All Science Journal Classification (ASJC) codes

General Neuroscience

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10.1016/j.neulet.2009.11.019

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Hashimoto, R., Hashimoto, H., Shintani, N., Ohi, K., Hori, H., Saitoh, O., Kosuga, A., Tatsumi, M., Iwata, N., Ozaki, N., Kamijima, K., Baba, A., Takeda, M., & Kunugi, H. (2010). Possible association between the pituitary adenylate cyclase-activating polypeptide (PACAP) gene and major depressive disorder. Neuroscience Letters, 468(3), 300-302. https://doi.org/10.1016/j.neulet.2009.11.019

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title = "Possible association between the pituitary adenylate cyclase-activating polypeptide (PACAP) gene and major depressive disorder",

abstract = "Pituitary adenylate cyclase-activating polypeptide (PACAP, ADCYAP1: adenylate cyclase-activating polypeptide 1) is a neuropeptide with neurotransmission modulating activity. The associations of the PACAP gene with schizophrenia and hippocampal volume have been reported. We recently reported depression-like behavior in the forced swimming test in PACAP deficient mice. Here we examined a possible association between the PACAP gene and major depressive disorder (MDD) in 637 patients and 967 controls and found that a genetic variant in the gene was associated with MDD. The present results suggest that PACAP signaling might contribute to the pathogenesis of MDD.",

keywords = "ADCYAP1, Depression, Major depressive disorder, PACAP, Single nucleotide polymorphism",

author = "Ryota Hashimoto and Hitoshi Hashimoto and Norihito Shintani and Kazutaka Ohi and Hiroaki Hori and Osamu Saitoh and Asako Kosuga and Masahiko Tatsumi and Nakao Iwata and Norio Ozaki and Kunitoshi Kamijima and Akemichi Baba and Masatoshi Takeda and Hiroshi Kunugi",

note = "Funding Information: This work was supported in part by Grants-in-Aid from the Japanese Ministry of Health, Labor and Welfare (H18-kokoro-005, H19-kokoro-002), the Japanese Ministry of Education, Culture, Sports, Science and Technology (18689030), CREST of JST, Grant-aid for Scientific Research on Priority Areas – Research on Pathomechanisms of Brain Disorders – from the MEXT (18023045) and Japan Foundation for Neuroscience and Mental Health.",

year = "2010",

month = jan,

day = "14",

doi = "10.1016/j.neulet.2009.11.019",

language = "English",

volume = "468",

pages = "300--302",

journal = "Neuroscience Letters",

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Hashimoto, R, Hashimoto, H, Shintani, N, Ohi, K, Hori, H, Saitoh, O, Kosuga, A, Tatsumi, M, Iwata, N, Ozaki, N, Kamijima, K, Baba, A, Takeda, M & Kunugi, H 2010, 'Possible association between the pituitary adenylate cyclase-activating polypeptide (PACAP) gene and major depressive disorder', Neuroscience Letters, vol. 468, no. 3, pp. 300-302. https://doi.org/10.1016/j.neulet.2009.11.019

TY - JOUR

T1 - Possible association between the pituitary adenylate cyclase-activating polypeptide (PACAP) gene and major depressive disorder

AU - Hashimoto, Ryota

AU - Hashimoto, Hitoshi

AU - Shintani, Norihito

AU - Ohi, Kazutaka

AU - Hori, Hiroaki

AU - Saitoh, Osamu

AU - Kosuga, Asako

AU - Tatsumi, Masahiko

AU - Iwata, Nakao

AU - Ozaki, Norio

AU - Kamijima, Kunitoshi

AU - Baba, Akemichi

AU - Takeda, Masatoshi

AU - Kunugi, Hiroshi

N1 - Funding Information: This work was supported in part by Grants-in-Aid from the Japanese Ministry of Health, Labor and Welfare (H18-kokoro-005, H19-kokoro-002), the Japanese Ministry of Education, Culture, Sports, Science and Technology (18689030), CREST of JST, Grant-aid for Scientific Research on Priority Areas – Research on Pathomechanisms of Brain Disorders – from the MEXT (18023045) and Japan Foundation for Neuroscience and Mental Health.

PY - 2010/1/14

Y1 - 2010/1/14

N2 - Pituitary adenylate cyclase-activating polypeptide (PACAP, ADCYAP1: adenylate cyclase-activating polypeptide 1) is a neuropeptide with neurotransmission modulating activity. The associations of the PACAP gene with schizophrenia and hippocampal volume have been reported. We recently reported depression-like behavior in the forced swimming test in PACAP deficient mice. Here we examined a possible association between the PACAP gene and major depressive disorder (MDD) in 637 patients and 967 controls and found that a genetic variant in the gene was associated with MDD. The present results suggest that PACAP signaling might contribute to the pathogenesis of MDD.

AB - Pituitary adenylate cyclase-activating polypeptide (PACAP, ADCYAP1: adenylate cyclase-activating polypeptide 1) is a neuropeptide with neurotransmission modulating activity. The associations of the PACAP gene with schizophrenia and hippocampal volume have been reported. We recently reported depression-like behavior in the forced swimming test in PACAP deficient mice. Here we examined a possible association between the PACAP gene and major depressive disorder (MDD) in 637 patients and 967 controls and found that a genetic variant in the gene was associated with MDD. The present results suggest that PACAP signaling might contribute to the pathogenesis of MDD.

KW - ADCYAP1

KW - Depression

KW - Major depressive disorder

KW - PACAP

KW - Single nucleotide polymorphism

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SN - 0304-3940

VL - 468

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JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 3

ER -

Possible association between the pituitary adenylate cyclase-activating polypeptide (PACAP) gene and major depressive disorder

Abstract

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