TY - JOUR
T1 - Possible association of β-arrestin 2 gene with methamphetamine use disorder, but not schizophrenia
AU - Ikeda, Masashi
AU - Ozaki, N.
AU - Suzuki, T.
AU - Kitajima, T.
AU - Yamanouchi, Y.
AU - Kinoshita, Y.
AU - Kishi, T.
AU - Sekine, Y.
AU - Iyo, M.
AU - Harano, M.
AU - Komiyama, T.
AU - Yamada, M.
AU - Sora, I.
AU - Ujike, H.
AU - Inada, T.
AU - Iwata, N.
PY - 2007/2
Y1 - 2007/2
N2 - Recent investigations suggest that the AKT/glycogen synthase kinase 3 (GSK3) signaling cascade may be associated with the pathophysiology of schizophrenia and methamphetamine (METH) use disorder. One important molecule related to this cascade is β-arrestin 2 (ARRB2). We therefore conducted a genetic case-control association analysis of the gene for ARRB2 with schizophrenia and METH use disorder in a Japanese population (547 people with schizophrenia, 177 with METH use disorder and 546 controls). A possible association of 'tag single nucleotide polymorphisms (SNPs)' was found in METH use disorder (rs1045280: Pgenotype = 0.0118, Pallele = 0.00351; rs2036657: Pallele = 0.0431; rs4790694: Pgenotype = 0.0167, Pallele = 0.0202), but no association was found with schizophrenia. We also evaluated the gene-gene interactions among ARRB2, AKT1, and GSK3B, which we previously reported for each of these diseases. However, no interaction was seen in our samples. This is the first association analysis of ARRB2, and our results indicate that ARRB2 may play a role in the pathophysiology of METH use disorder.
AB - Recent investigations suggest that the AKT/glycogen synthase kinase 3 (GSK3) signaling cascade may be associated with the pathophysiology of schizophrenia and methamphetamine (METH) use disorder. One important molecule related to this cascade is β-arrestin 2 (ARRB2). We therefore conducted a genetic case-control association analysis of the gene for ARRB2 with schizophrenia and METH use disorder in a Japanese population (547 people with schizophrenia, 177 with METH use disorder and 546 controls). A possible association of 'tag single nucleotide polymorphisms (SNPs)' was found in METH use disorder (rs1045280: Pgenotype = 0.0118, Pallele = 0.00351; rs2036657: Pallele = 0.0431; rs4790694: Pgenotype = 0.0167, Pallele = 0.0202), but no association was found with schizophrenia. We also evaluated the gene-gene interactions among ARRB2, AKT1, and GSK3B, which we previously reported for each of these diseases. However, no interaction was seen in our samples. This is the first association analysis of ARRB2, and our results indicate that ARRB2 may play a role in the pathophysiology of METH use disorder.
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U2 - 10.1111/j.1601-183X.2006.00237.x
DO - 10.1111/j.1601-183X.2006.00237.x
M3 - Article
C2 - 17233643
AN - SCOPUS:33846122964
SN - 1601-1848
VL - 6
SP - 107
EP - 112
JO - Genes, Brain and Behavior
JF - Genes, Brain and Behavior
IS - 1
ER -