Possible involvement of nitric oxide in quinolinic acid-induced convulsion in mice

Toshi Aki Nakamura, Kiyofumi Yamada, Takaaki Hasegawa, Toshitaka Nabeshima

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Quinolinic acid (QA) induced clonic and tonic convulsions in mice when it was injected into the cerebral ventricle. Pretreatment with l-arginine (L-Arg), a substrate of nitric oxide (NO) synthase (NOS), and/or 5,6,7,8-tetrahydrobiopterin (THB), a cofactor of NOS, tended to potentiate QA-induced convulsion. NG-monomethyl-l-arginine (NMMA), a competitive NOS inhibitor, diminished QA-induced convulsion. This effect of NMMA was attenuated by coadministration of L-Arg or THB. Sodium nitroprusside (SNP), which spontaneously releases NO, did not potentiate, but diminished QA-induced convulsion. These findings suggest that an endogenous NO may be involved, at least in part, in QA-induced convulsion in mice, and that an exogenous NO released from SNP may cause downregulation of N-methyl-D-aspartate (NMDA) receptor activity, and thereby prevent the excessive excitation of NMDA receptors and subsequent convulsion caused by QA.

Original languageEnglish
Pages (from-to)309-312
Number of pages4
JournalPharmacology, Biochemistry and Behavior
Volume51
Issue number2-3
DOIs
Publication statusPublished - 01-01-1995
Externally publishedYes

Fingerprint

Quinolinic Acid
Nitric Oxide
Seizures
Nitric Oxide Synthase
Arginine
Nitroprusside
N-Methyl-D-Aspartate Receptors
Tonic-Clonic Epilepsy
Cerebral Ventricles
Down-Regulation
Substrates

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

Cite this

Nakamura, Toshi Aki ; Yamada, Kiyofumi ; Hasegawa, Takaaki ; Nabeshima, Toshitaka. / Possible involvement of nitric oxide in quinolinic acid-induced convulsion in mice. In: Pharmacology, Biochemistry and Behavior. 1995 ; Vol. 51, No. 2-3. pp. 309-312.
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Possible involvement of nitric oxide in quinolinic acid-induced convulsion in mice. / Nakamura, Toshi Aki; Yamada, Kiyofumi; Hasegawa, Takaaki; Nabeshima, Toshitaka.

In: Pharmacology, Biochemistry and Behavior, Vol. 51, No. 2-3, 01.01.1995, p. 309-312.

Research output: Contribution to journalArticle

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AU - Yamada, Kiyofumi

AU - Hasegawa, Takaaki

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