Abstract
We report the molecular cloning and characterization of two secretory proteins specifically expressed in vomeronasal and posterior glands of the nasal septum, the ducts of which open into the lumen of the vomeronasal organ. These two proteins are members of the lipocalin superfamily, consisting of hydrophobic ligand carriers. We immunohistochemically localized one of the proteins in the mucus covering the vomeronasal sensory epithelium, where the primary reception of pheromone takes place. The immunoreactivity on the vomeronasal sensory epithelium was evident in the neonatal and post-pubertal periods, when the close contact between animals plays critical roles in suckling and sexual behaviors, respectively. These results suggest that small lipophilic molecules stimulate the accessory olfactory system to regulate the reproductive behavior of mice.
Original language | English |
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Pages (from-to) | 5835-5842 |
Number of pages | 8 |
Journal | EMBO Journal |
Volume | 13 |
Issue number | 24 |
DOIs | |
Publication status | Published - 15-12-1994 |
Externally published | Yes |
All Science Journal Classification (ASJC) codes
- General Neuroscience
- Molecular Biology
- General Biochemistry,Genetics and Molecular Biology
- General Immunology and Microbiology