Post-natal treatment by a blood-brain-barrier permeable calpain inhibitor, SNJ1945 rescued defective function in lissencephaly

Shiori Toba, Yasuhisa Tamura, Kanako Kumamoto, Masami Yamada, Keizo Takao, Satoko Hattori, Tsuyoshi Miyakawa, Yosky Kataoka, Mitsuyoshi Azuma, Kiyoshi Hayasaka, Masano Amamoto, Keiko Tominaga, Anthony Wynshaw-Boris, Hideki Wanibuchi, Yuichiro Oka, Makoto Sato, Mitsuhiro Kato, Shinji Hirotsune

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15 Citations (Scopus)

Abstract

Toward a therapeutic intervention of lissencephaly, we applied a novel calpain inhibitor, SNJ1945. Peri-natal or post-natal treatment with SNJ1945 rescued defective neuronal migration in Lis1+/− mice, impaired behavioral performance and improvement of 18F-FDG uptake. Furthermore, SNJ1945 improved the neural circuit formation and retrograde transport of NFG in Lis1+/− mice. Thus, SNJ1945 is a potential drug for the treatment of human lissencephaly patients.

Original languageEnglish
Pages (from-to)1-10
Number of pages10
JournalScientific reports
Volume3
DOIs
Publication statusPublished - 06-02-2013

All Science Journal Classification (ASJC) codes

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    Toba, S., Tamura, Y., Kumamoto, K., Yamada, M., Takao, K., Hattori, S., Miyakawa, T., Kataoka, Y., Azuma, M., Hayasaka, K., Amamoto, M., Tominaga, K., Wynshaw-Boris, A., Wanibuchi, H., Oka, Y., Sato, M., Kato, M., & Hirotsune, S. (2013). Post-natal treatment by a blood-brain-barrier permeable calpain inhibitor, SNJ1945 rescued defective function in lissencephaly. Scientific reports, 3, 1-10. https://doi.org/10.1038/srep01224