Post-natal treatment by a blood-brain-barrier permeable calpain inhibitor, SNJ1945 rescued defective function in lissencephaly

Shiori Toba, Yasuhisa Tamura, Kanako Kumamoto, Masami Yamada, Keizo Takao, Satoko Takai, Tsuyoshi Miyakawa, Yosky Kataoka, Mitsuyoshi Azuma, Kiyoshi Hayasaka, Masano Amamoto, Keiko Tominaga, Anthony Wynshaw-Boris, Hideki Wanibuchi, Yuichiro Oka, Makoto Sato, Mitsuhiro Kato, Shinji Hirotsune

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Toward a therapeutic intervention of lissencephaly, we applied a novel calpain inhibitor, SNJ1945. Peri-natal or post-natal treatment with SNJ1945 rescued defective neuronal migration in Lis1+/− mice, impaired behavioral performance and improvement of 18F-FDG uptake. Furthermore, SNJ1945 improved the neural circuit formation and retrograde transport of NFG in Lis1+/− mice. Thus, SNJ1945 is a potential drug for the treatment of human lissencephaly patients.

Original languageEnglish
Pages (from-to)1-10
Number of pages10
JournalScientific Reports
Volume3
DOIs
Publication statusPublished - 06-02-2013

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Lissencephaly
Blood-Brain Barrier
Fluorodeoxyglucose F18
Therapeutics
Pharmaceutical Preparations
calpain inhibitors

All Science Journal Classification (ASJC) codes

  • General

Cite this

Toba, Shiori ; Tamura, Yasuhisa ; Kumamoto, Kanako ; Yamada, Masami ; Takao, Keizo ; Takai, Satoko ; Miyakawa, Tsuyoshi ; Kataoka, Yosky ; Azuma, Mitsuyoshi ; Hayasaka, Kiyoshi ; Amamoto, Masano ; Tominaga, Keiko ; Wynshaw-Boris, Anthony ; Wanibuchi, Hideki ; Oka, Yuichiro ; Sato, Makoto ; Kato, Mitsuhiro ; Hirotsune, Shinji. / Post-natal treatment by a blood-brain-barrier permeable calpain inhibitor, SNJ1945 rescued defective function in lissencephaly. In: Scientific Reports. 2013 ; Vol. 3. pp. 1-10.
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abstract = "Toward a therapeutic intervention of lissencephaly, we applied a novel calpain inhibitor, SNJ1945. Peri-natal or post-natal treatment with SNJ1945 rescued defective neuronal migration in Lis1+/− mice, impaired behavioral performance and improvement of 18F-FDG uptake. Furthermore, SNJ1945 improved the neural circuit formation and retrograde transport of NFG in Lis1+/− mice. Thus, SNJ1945 is a potential drug for the treatment of human lissencephaly patients.",
author = "Shiori Toba and Yasuhisa Tamura and Kanako Kumamoto and Masami Yamada and Keizo Takao and Satoko Takai and Tsuyoshi Miyakawa and Yosky Kataoka and Mitsuyoshi Azuma and Kiyoshi Hayasaka and Masano Amamoto and Keiko Tominaga and Anthony Wynshaw-Boris and Hideki Wanibuchi and Yuichiro Oka and Makoto Sato and Mitsuhiro Kato and Shinji Hirotsune",
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Toba, S, Tamura, Y, Kumamoto, K, Yamada, M, Takao, K, Takai, S, Miyakawa, T, Kataoka, Y, Azuma, M, Hayasaka, K, Amamoto, M, Tominaga, K, Wynshaw-Boris, A, Wanibuchi, H, Oka, Y, Sato, M, Kato, M & Hirotsune, S 2013, 'Post-natal treatment by a blood-brain-barrier permeable calpain inhibitor, SNJ1945 rescued defective function in lissencephaly', Scientific Reports, vol. 3, pp. 1-10. https://doi.org/10.1038/srep01224

Post-natal treatment by a blood-brain-barrier permeable calpain inhibitor, SNJ1945 rescued defective function in lissencephaly. / Toba, Shiori; Tamura, Yasuhisa; Kumamoto, Kanako; Yamada, Masami; Takao, Keizo; Takai, Satoko; Miyakawa, Tsuyoshi; Kataoka, Yosky; Azuma, Mitsuyoshi; Hayasaka, Kiyoshi; Amamoto, Masano; Tominaga, Keiko; Wynshaw-Boris, Anthony; Wanibuchi, Hideki; Oka, Yuichiro; Sato, Makoto; Kato, Mitsuhiro; Hirotsune, Shinji.

In: Scientific Reports, Vol. 3, 06.02.2013, p. 1-10.

Research output: Contribution to journalArticle

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AU - Toba, Shiori

AU - Tamura, Yasuhisa

AU - Kumamoto, Kanako

AU - Yamada, Masami

AU - Takao, Keizo

AU - Takai, Satoko

AU - Miyakawa, Tsuyoshi

AU - Kataoka, Yosky

AU - Azuma, Mitsuyoshi

AU - Hayasaka, Kiyoshi

AU - Amamoto, Masano

AU - Tominaga, Keiko

AU - Wynshaw-Boris, Anthony

AU - Wanibuchi, Hideki

AU - Oka, Yuichiro

AU - Sato, Makoto

AU - Kato, Mitsuhiro

AU - Hirotsune, Shinji

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