TY - JOUR
T1 - Post-occlusional hyperemia for fractional flow reserve assessment and pull-back curve analysis
AU - Hirata, T.
AU - Tanigaki, T.
AU - Kawase, Y.
AU - Hirakawa, A.
AU - Omori, H.
AU - Okamoto, S.
AU - Ota, H.
AU - Sobue, Y.
AU - Kikuchi, J.
AU - Okubo, M.
AU - Kamiya, H.
AU - Kawasaki, M.
AU - Suzuki, T.
AU - Pijls, N. H.J.
AU - Matsuo, H.
N1 - Publisher Copyright:
© 2019, Japanese Association of Cardiovascular Intervention and Therapeutics.
PY - 2020/4/1
Y1 - 2020/4/1
N2 - Balloon occlusion is a potential method for inducing hyperemia to measure post-percutaneous coronary intervention (PCI) fractional flow reserve (FFR). The objective of this study was to determine the clinical usefulness of post-occlusional hyperemia. FFRs measured using post-occlusional hyperemia caused by 30 (FFRoccl30) and 60 s (FFRoccl60) of balloon occlusion after PCI were compared in 60 lesions from 60 patients. The duration of hyperemia was also measured. There was a strong correlation between FFRoccl30 and FFRoccl60 (r = 0.969, p < 0.01). The duration of hyperemia was significantly longer with FFRoccl60 than with FFRoccl30 (68 ± 23 vs. 37 ± 15 s, p < 0.01). The time required for pullback curve analysis was around 45 s. However, in 7 (12%) cases, the duration of hyperemia with FFRoccl60 was < 45 s, which was not enough for pull-back curve analysis. To predict the duration of hyperemia with FFRoccl60 ≥ 45 s, the receiver operating characteristic curve analysis revealed a cut-off value of 25 s of hyperemia with FFRoccl30. FFRoccl30 is sufficient for diagnostic purposes. FFRoccl60 is suitable for pull-back curve analysis in select cases based on predictions made using the duration of hyperemia with FFRoccl30.
AB - Balloon occlusion is a potential method for inducing hyperemia to measure post-percutaneous coronary intervention (PCI) fractional flow reserve (FFR). The objective of this study was to determine the clinical usefulness of post-occlusional hyperemia. FFRs measured using post-occlusional hyperemia caused by 30 (FFRoccl30) and 60 s (FFRoccl60) of balloon occlusion after PCI were compared in 60 lesions from 60 patients. The duration of hyperemia was also measured. There was a strong correlation between FFRoccl30 and FFRoccl60 (r = 0.969, p < 0.01). The duration of hyperemia was significantly longer with FFRoccl60 than with FFRoccl30 (68 ± 23 vs. 37 ± 15 s, p < 0.01). The time required for pullback curve analysis was around 45 s. However, in 7 (12%) cases, the duration of hyperemia with FFRoccl60 was < 45 s, which was not enough for pull-back curve analysis. To predict the duration of hyperemia with FFRoccl60 ≥ 45 s, the receiver operating characteristic curve analysis revealed a cut-off value of 25 s of hyperemia with FFRoccl30. FFRoccl30 is sufficient for diagnostic purposes. FFRoccl60 is suitable for pull-back curve analysis in select cases based on predictions made using the duration of hyperemia with FFRoccl30.
KW - Fractional flow reserve
KW - Hyperemia
KW - Percutaneous coronary intervention
UR - https://www.scopus.com/pages/publications/85073942927
UR - https://www.scopus.com/pages/publications/85073942927#tab=citedBy
U2 - 10.1007/s12928-019-00579-9
DO - 10.1007/s12928-019-00579-9
M3 - Article
C2 - 30788697
AN - SCOPUS:85073942927
SN - 1868-4300
VL - 35
SP - 142
EP - 149
JO - Cardiovascular Intervention and Therapeutics
JF - Cardiovascular Intervention and Therapeutics
IS - 2
ER -