Post-transplant membranous nephropathy associated with chronic active antibody-mediated rejection and hepatitis C infection after deceased donor renal transplantation

Tomohito Doke, Waichi Sato, Kazuo Takahashi, Hiroki Hayashi, Sigehisa Koide, Hitomi Sasaki, Mamoru Kusaka, Ryoichi Shiroki, Kiyotaka Hoshinaga, Asami Takeda, Yukio Yuzawa, Midori Hasegawa

Research output: Contribution to journalArticle

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Abstract

A 53-year-old woman who had undergone deceased donor kidney transplantation twice, at 35 and 43 years of age, presented with renal impairment. She was infected with hepatitis C virus (HCV). The histology of the graft kidney revealed post-transplant membranous nephropathy (MN) with podocytic infolding and antibodymediated rejection (AMR). IgG subclass staining showed fine granular deposits of IgG1 and IgG3, but not IgG4, in the glomerular capillary walls. Panel reactive antibody scores for human leukocyte antigen class I and class II were 92.67% and 66.68%, respectively. Thus, this case of post-transplanted MN was considered to be associated with AMR and HCV infection.

Original languageEnglish
Pages (from-to)375-380
Number of pages6
JournalInternal Medicine
Volume55
Issue number4
DOIs
Publication statusPublished - 15-02-2016

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Membranous Glomerulonephritis
Hepatitis C
Kidney Transplantation
Immunoglobulin G
Tissue Donors
Transplants
Antibodies
Infection
Hepacivirus
Kidney
Virus Diseases
HLA Antigens
Histology
Staining and Labeling

All Science Journal Classification (ASJC) codes

  • Internal Medicine

Cite this

Doke, Tomohito ; Sato, Waichi ; Takahashi, Kazuo ; Hayashi, Hiroki ; Koide, Sigehisa ; Sasaki, Hitomi ; Kusaka, Mamoru ; Shiroki, Ryoichi ; Hoshinaga, Kiyotaka ; Takeda, Asami ; Yuzawa, Yukio ; Hasegawa, Midori. / Post-transplant membranous nephropathy associated with chronic active antibody-mediated rejection and hepatitis C infection after deceased donor renal transplantation. In: Internal Medicine. 2016 ; Vol. 55, No. 4. pp. 375-380.
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Post-transplant membranous nephropathy associated with chronic active antibody-mediated rejection and hepatitis C infection after deceased donor renal transplantation. / Doke, Tomohito; Sato, Waichi; Takahashi, Kazuo; Hayashi, Hiroki; Koide, Sigehisa; Sasaki, Hitomi; Kusaka, Mamoru; Shiroki, Ryoichi; Hoshinaga, Kiyotaka; Takeda, Asami; Yuzawa, Yukio; Hasegawa, Midori.

In: Internal Medicine, Vol. 55, No. 4, 15.02.2016, p. 375-380.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Post-transplant membranous nephropathy associated with chronic active antibody-mediated rejection and hepatitis C infection after deceased donor renal transplantation

AU - Doke, Tomohito

AU - Sato, Waichi

AU - Takahashi, Kazuo

AU - Hayashi, Hiroki

AU - Koide, Sigehisa

AU - Sasaki, Hitomi

AU - Kusaka, Mamoru

AU - Shiroki, Ryoichi

AU - Hoshinaga, Kiyotaka

AU - Takeda, Asami

AU - Yuzawa, Yukio

AU - Hasegawa, Midori

PY - 2016/2/15

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