Postischemic mild hypothermia alleviates hearing loss because of transient ischemia

Shoichiro Takeda, Nobuhiro Hakuba, Tadashi Yoshida, Kensuke Fujita, Naohito Hato, Ryuji Hata, Jun Hyodo, Kiyofumi Gyo

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6 Citations (Scopus)

Abstract

The effect of postischemic mild hypothermia on the inner ear has not been clari¢ed. In this study,we investigatedwhether hypothermia after transient ischemia could prevent cochlear damage and its therapeutic time window. Mongolian gerbils were divided into six groups: a sham-operation group, a normothermia group, and four hypothermia groups inwhich hypothermiawas induced1-7,1-4, 3-6, and 6-9 h after reperfusion. Animals subjected to postischemic mildhypothermiawithin 3 h after reperfusion had attenuatedhearing loss and inner hair cell loss.The protective effect was greater when hypothermia was induced earlier and had a longer duration. This implies that mild hypothermia after ischemia could have therapeutic effects for inner ear ischemic damage. NeuroReport 19:1325-1328

Original languageEnglish
Pages (from-to)1325-1328
Number of pages4
JournalNeuroreport
Volume19
Issue number13
DOIs
Publication statusPublished - 27-08-2008

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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    Takeda, S., Hakuba, N., Yoshida, T., Fujita, K., Hato, N., Hata, R., Hyodo, J., & Gyo, K. (2008). Postischemic mild hypothermia alleviates hearing loss because of transient ischemia. Neuroreport, 19(13), 1325-1328. https://doi.org/10.1097/WNR.0b013e32830b5f73