Postischemic mild hypothermia alleviates hearing loss because of transient ischemia

Shoichiro Takeda, Nobuhiro Hakuba, Tadashi Yoshida, Kensuke Fujita, Naohito Hato, Ryuji Hata, Jun Hyodo, Kiyofumi Gyo

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The effect of postischemic mild hypothermia on the inner ear has not been clari¢ed. In this study,we investigatedwhether hypothermia after transient ischemia could prevent cochlear damage and its therapeutic time window. Mongolian gerbils were divided into six groups: a sham-operation group, a normothermia group, and four hypothermia groups inwhich hypothermiawas induced1-7,1-4, 3-6, and 6-9 h after reperfusion. Animals subjected to postischemic mildhypothermiawithin 3 h after reperfusion had attenuatedhearing loss and inner hair cell loss.The protective effect was greater when hypothermia was induced earlier and had a longer duration. This implies that mild hypothermia after ischemia could have therapeutic effects for inner ear ischemic damage. NeuroReport 19:1325-1328

Original languageEnglish
Pages (from-to)1325-1328
Number of pages4
JournalNeuroReport
Volume19
Issue number13
DOIs
Publication statusPublished - 27-08-2008

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Hypothermia
Hearing Loss
Ischemia
Inner Ear
Inner Auditory Hair Cells
Reperfusion
Induced Hypothermia
Gerbillinae
Cochlea
Alopecia
Therapeutic Uses
Therapeutics

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Takeda, S., Hakuba, N., Yoshida, T., Fujita, K., Hato, N., Hata, R., ... Gyo, K. (2008). Postischemic mild hypothermia alleviates hearing loss because of transient ischemia. NeuroReport, 19(13), 1325-1328. https://doi.org/10.1097/WNR.0b013e32830b5f73
Takeda, Shoichiro ; Hakuba, Nobuhiro ; Yoshida, Tadashi ; Fujita, Kensuke ; Hato, Naohito ; Hata, Ryuji ; Hyodo, Jun ; Gyo, Kiyofumi. / Postischemic mild hypothermia alleviates hearing loss because of transient ischemia. In: NeuroReport. 2008 ; Vol. 19, No. 13. pp. 1325-1328.
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Takeda, S, Hakuba, N, Yoshida, T, Fujita, K, Hato, N, Hata, R, Hyodo, J & Gyo, K 2008, 'Postischemic mild hypothermia alleviates hearing loss because of transient ischemia', NeuroReport, vol. 19, no. 13, pp. 1325-1328. https://doi.org/10.1097/WNR.0b013e32830b5f73

Postischemic mild hypothermia alleviates hearing loss because of transient ischemia. / Takeda, Shoichiro; Hakuba, Nobuhiro; Yoshida, Tadashi; Fujita, Kensuke; Hato, Naohito; Hata, Ryuji; Hyodo, Jun; Gyo, Kiyofumi.

In: NeuroReport, Vol. 19, No. 13, 27.08.2008, p. 1325-1328.

Research output: Contribution to journalArticle

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