Postischemic mild hypothermia alleviates hearing loss because of transient ischemia

Shoichiro Takeda, Nobuhiro Hakuba, Tadashi Yoshida, Kensuke Fujita, Naohito Hato, Ryuji Hata, Jun Hyodo, Kiyofumi Gyo

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)


The effect of postischemic mild hypothermia on the inner ear has not been clari¢ed. In this study,we investigatedwhether hypothermia after transient ischemia could prevent cochlear damage and its therapeutic time window. Mongolian gerbils were divided into six groups: a sham-operation group, a normothermia group, and four hypothermia groups inwhich hypothermiawas induced1-7,1-4, 3-6, and 6-9 h after reperfusion. Animals subjected to postischemic mildhypothermiawithin 3 h after reperfusion had attenuatedhearing loss and inner hair cell loss.The protective effect was greater when hypothermia was induced earlier and had a longer duration. This implies that mild hypothermia after ischemia could have therapeutic effects for inner ear ischemic damage. NeuroReport 19:1325-1328

Original languageEnglish
Pages (from-to)1325-1328
Number of pages4
Issue number13
Publication statusPublished - 27-08-2008
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General Neuroscience


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