Postischemic mild hypothermia alleviates hearing loss because of transient ischemia

Shoichiro Takeda; Nobuhiro Hakuba; Tadashi Yoshida; Kensuke Fujita; Naohito Hato; Ryuji Hata; Jun Hyodo; Kiyofumi Gyo

doi:10.1097/WNR.0b013e32830b5f73

Postischemic mild hypothermia alleviates hearing loss because of transient ischemia

Shoichiro Takeda, Nobuhiro Hakuba, Tadashi Yoshida, Kensuke Fujita, Naohito Hato, Ryuji Hata, Jun Hyodo, Kiyofumi Gyo

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

The effect of postischemic mild hypothermia on the inner ear has not been clari¢ed. In this study,we investigatedwhether hypothermia after transient ischemia could prevent cochlear damage and its therapeutic time window. Mongolian gerbils were divided into six groups: a sham-operation group, a normothermia group, and four hypothermia groups inwhich hypothermiawas induced1-7,1-4, 3-6, and 6-9 h after reperfusion. Animals subjected to postischemic mildhypothermiawithin 3 h after reperfusion had attenuatedhearing loss and inner hair cell loss.The protective effect was greater when hypothermia was induced earlier and had a longer duration. This implies that mild hypothermia after ischemia could have therapeutic effects for inner ear ischemic damage. NeuroReport 19:1325-1328

Original language	English
Pages (from-to)	1325-1328
Number of pages	4
Journal	Neuroreport
Volume	19
Issue number	13
DOIs	https://doi.org/10.1097/WNR.0b013e32830b5f73
Publication status	Published - 27-08-2008
Externally published	Yes

All Science Journal Classification (ASJC) codes

General Neuroscience

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10.1097/WNR.0b013e32830b5f73

Cite this

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abstract = "The effect of postischemic mild hypothermia on the inner ear has not been clari¢ed. In this study,we investigatedwhether hypothermia after transient ischemia could prevent cochlear damage and its therapeutic time window. Mongolian gerbils were divided into six groups: a sham-operation group, a normothermia group, and four hypothermia groups inwhich hypothermiawas induced1-7,1-4, 3-6, and 6-9 h after reperfusion. Animals subjected to postischemic mildhypothermiawithin 3 h after reperfusion had attenuatedhearing loss and inner hair cell loss.The protective effect was greater when hypothermia was induced earlier and had a longer duration. This implies that mild hypothermia after ischemia could have therapeutic effects for inner ear ischemic damage. NeuroReport 19:1325-1328",

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AU - Takeda, Shoichiro

AU - Hakuba, Nobuhiro

AU - Yoshida, Tadashi

AU - Fujita, Kensuke

AU - Hato, Naohito

AU - Hata, Ryuji

AU - Hyodo, Jun

AU - Gyo, Kiyofumi

PY - 2008/8/27

Y1 - 2008/8/27

N2 - The effect of postischemic mild hypothermia on the inner ear has not been clari¢ed. In this study,we investigatedwhether hypothermia after transient ischemia could prevent cochlear damage and its therapeutic time window. Mongolian gerbils were divided into six groups: a sham-operation group, a normothermia group, and four hypothermia groups inwhich hypothermiawas induced1-7,1-4, 3-6, and 6-9 h after reperfusion. Animals subjected to postischemic mildhypothermiawithin 3 h after reperfusion had attenuatedhearing loss and inner hair cell loss.The protective effect was greater when hypothermia was induced earlier and had a longer duration. This implies that mild hypothermia after ischemia could have therapeutic effects for inner ear ischemic damage. NeuroReport 19:1325-1328

AB - The effect of postischemic mild hypothermia on the inner ear has not been clari¢ed. In this study,we investigatedwhether hypothermia after transient ischemia could prevent cochlear damage and its therapeutic time window. Mongolian gerbils were divided into six groups: a sham-operation group, a normothermia group, and four hypothermia groups inwhich hypothermiawas induced1-7,1-4, 3-6, and 6-9 h after reperfusion. Animals subjected to postischemic mildhypothermiawithin 3 h after reperfusion had attenuatedhearing loss and inner hair cell loss.The protective effect was greater when hypothermia was induced earlier and had a longer duration. This implies that mild hypothermia after ischemia could have therapeutic effects for inner ear ischemic damage. NeuroReport 19:1325-1328

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Postischemic mild hypothermia alleviates hearing loss because of transient ischemia

Abstract

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