Potential neural progenitor cells in fetal liver and regenerating liver

Fuminari Komatsu, Imre Farkas, Hiroyasu Akatsu, Kiyohide Kojima, Takeo Fukushima, Hidechika Okada

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


From unfractionated embryonic mice liver cells, appreciable amount of spherical bodies containing nestin-positive cells were generated in the presence of neuronal growth factors. Following cultivation on poly-d-lysine/laminin- coated slips, approximately 70% of the cells expressed neuronal markers, and 16% had long processes. Functional analysis of these long-process-bearing cells with the whole-cell patch clamp method showed an inward current in response to glutamate, GABA, and serotonin as the neuronal characteristics. Furthermore, regenerating liver in adult mice also contained nestin-positive cells to the same extent as fetal liver. Regenerating liver could have potential as a source of neural cells for autologous transplantation.

Original languageEnglish
Pages (from-to)209-217
Number of pages9
Issue number3
Publication statusPublished - 03-2008
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering
  • Clinical Biochemistry
  • Cell Biology


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