Potential of a new MRI for visualizing cerebellar involvement in progressive supranuclear palsy

Kazuhiro Hara, Hirohisa Watanabe, Mizuki Ito, Takashi Tsuboi, Hazuki Watanabe, Ryoichi Nakamura, Jo Senda, Naoki Atsuta, Hiroaki Adachi, Ikuko Aiba, Shinji Naganawa, Gen Sobue

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6 Citations (Scopus)

Abstract

Objectives: We assessed the usefulness of differential diagnosis of parkinsonism by evaluating lesions of the decussation of the superior cerebellar peduncle (SCP) in patients with progressive supranuclear palsy (PSP) using a new MRI procedure known as readout segmentation of long variable echo-trains (RESOLVE). Methods: We evaluated 100 cases, consisting of 20 with PSP, 24 with Parkinson's disease (PD), 13 with multiple system atrophy with predominant parkinsonism (MSA-P), 18 with multiple system atrophy with predominant cerebellar ataxia (MSA-C), and 24 controls. All patients were scored on the Unified Parkinson's Disease Rating Scale Part III and the Scale for the Assessment and Rating Scale of Ataxia, and MRI using RESOLVE was conducted. Results: Images acquired by this MRI procedure clearly showed high intensity areas corresponding to the decussation of the SCP in all controls, PD, and MSA patients. In contrast, ten of the 20 PSP patients exhibited abnormal iso intensities of the decussation of the SCP, while the other 10 showed high intensity signals. Among the PSP patients, there were no differences in clinical features between those with and those without visualization of the decussation of the SCP. Iso intensity signals had a sensitivity of 50% and a specificity of 100% for differentiating PSP from PD, MSA, and controls. Conclusion: This MRI procedure (RESOLVE) shows a potential for detecting the involvement of the decussation of the SCP in PSP, and can be used for discriminating PSP from PD and MSA-P.

Original languageEnglish
Pages (from-to)157-161
Number of pages5
JournalParkinsonism and Related Disorders
Volume20
Issue number2
DOIs
Publication statusPublished - 01-02-2014
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Neurology
  • Geriatrics and Gerontology
  • Clinical Neurology

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    Hara, K., Watanabe, H., Ito, M., Tsuboi, T., Watanabe, H., Nakamura, R., Senda, J., Atsuta, N., Adachi, H., Aiba, I., Naganawa, S., & Sobue, G. (2014). Potential of a new MRI for visualizing cerebellar involvement in progressive supranuclear palsy. Parkinsonism and Related Disorders, 20(2), 157-161. https://doi.org/10.1016/j.parkreldis.2013.10.007