Potential of boron neutron capture therapy (BNCT) for epithelioid sarcoma

Takuya Fujimoto; Tooru Andoh; Tamotsu Sudo; Toshiko Sakuma; Ikuo Fujita; Yoshinori Sakurai; Takushi Takata; Hiroki Tanaka; Teruya Kawamoto; Shunsuke Yahiro; Hitomi Hara; Naomasa Fukase; Toshihiro Akisue; Hideki Ichikawa; Ryosuke Kuroda; Minoru Suzuki

doi:10.1016/j.apradiso.2025.111846

Potential of boron neutron capture therapy (BNCT) for epithelioid sarcoma

Takuya Fujimoto
, Tooru Andoh
, Tamotsu Sudo
, Toshiko Sakuma
, Ikuo Fujita
, Yoshinori Sakurai
, Takushi Takata
, Hiroki Tanaka
, Teruya Kawamoto
, Shunsuke Yahiro
, Hitomi Hara
, Naomasa Fukase
, Toshihiro Akisue
, Hideki Ichikawa
, Ryosuke Kuroda
, Minoru Suzuki

Research output: Contribution to journal › Article › peer-review

Abstract

Epithelioid sarcoma (ES) is a very rare malignant tumor with few effective treatments other than surgical resection. In this study, the efficacy of BNCT for ES was examined using human ES-derived VA-ES-BJ cell-bearing nude mice. Only tumors in the BNCT group injected with p-borono-_L-phenylalanine-fructose complex and irradiated with neutrons were destroyed. This study suggests the potential of BNCT as a new option for the treatment of human ES.

Original language	English
Article number	111846
Journal	Applied Radiation and Isotopes
Volume	222
DOIs	https://doi.org/10.1016/j.apradiso.2025.111846
Publication status	Published - 08-2025
Externally published	Yes

All Science Journal Classification (ASJC) codes

Radiation

Access to Document

10.1016/j.apradiso.2025.111846

Cite this

Fujimoto, T., Andoh, T., Sudo, T., Sakuma, T., Fujita, I., Sakurai, Y., Takata, T., Tanaka, H., Kawamoto, T., Yahiro, S., Hara, H., Fukase, N., Akisue, T., Ichikawa, H., Kuroda, R., & Suzuki, M. (2025). Potential of boron neutron capture therapy (BNCT) for epithelioid sarcoma. Applied Radiation and Isotopes, 222, Article 111846. https://doi.org/10.1016/j.apradiso.2025.111846

@article{88d940783b2a40e1855190a42a259ae5,

title = "Potential of boron neutron capture therapy (BNCT) for epithelioid sarcoma",

abstract = "Epithelioid sarcoma (ES) is a very rare malignant tumor with few effective treatments other than surgical resection. In this study, the efficacy of BNCT for ES was examined using human ES-derived VA-ES-BJ cell-bearing nude mice. Only tumors in the BNCT group injected with p-borono-L-phenylalanine-fructose complex and irradiated with neutrons were destroyed. This study suggests the potential of BNCT as a new option for the treatment of human ES.",

keywords = "Boron neutron capture therapy (BNCT), Cell line, Epithelioid sarcoma, p-borono--phenylalanine (L-BPA), VA-ES-BJ",

author = "Takuya Fujimoto and Tooru Andoh and Tamotsu Sudo and Toshiko Sakuma and Ikuo Fujita and Yoshinori Sakurai and Takushi Takata and Hiroki Tanaka and Teruya Kawamoto and Shunsuke Yahiro and Hitomi Hara and Naomasa Fukase and Toshihiro Akisue and Hideki Ichikawa and Ryosuke Kuroda and Minoru Suzuki",

note = "Publisher Copyright: {\textcopyright} 2025 Elsevier Ltd",

year = "2025",

month = aug,

doi = "10.1016/j.apradiso.2025.111846",

language = "English",

volume = "222",

journal = "Applied Radiation and Isotopes",

issn = "0969-8043",

publisher = "Elsevier Ltd",

}

TY - JOUR

T1 - Potential of boron neutron capture therapy (BNCT) for epithelioid sarcoma

AU - Fujimoto, Takuya

AU - Andoh, Tooru

AU - Sudo, Tamotsu

AU - Sakuma, Toshiko

AU - Fujita, Ikuo

AU - Sakurai, Yoshinori

AU - Takata, Takushi

AU - Tanaka, Hiroki

AU - Kawamoto, Teruya

AU - Yahiro, Shunsuke

AU - Hara, Hitomi

AU - Fukase, Naomasa

AU - Akisue, Toshihiro

AU - Ichikawa, Hideki

AU - Kuroda, Ryosuke

AU - Suzuki, Minoru

PY - 2025/8

Y1 - 2025/8

N2 - Epithelioid sarcoma (ES) is a very rare malignant tumor with few effective treatments other than surgical resection. In this study, the efficacy of BNCT for ES was examined using human ES-derived VA-ES-BJ cell-bearing nude mice. Only tumors in the BNCT group injected with p-borono-L-phenylalanine-fructose complex and irradiated with neutrons were destroyed. This study suggests the potential of BNCT as a new option for the treatment of human ES.

AB - Epithelioid sarcoma (ES) is a very rare malignant tumor with few effective treatments other than surgical resection. In this study, the efficacy of BNCT for ES was examined using human ES-derived VA-ES-BJ cell-bearing nude mice. Only tumors in the BNCT group injected with p-borono-L-phenylalanine-fructose complex and irradiated with neutrons were destroyed. This study suggests the potential of BNCT as a new option for the treatment of human ES.

KW - Boron neutron capture therapy (BNCT)

KW - Cell line

KW - Epithelioid sarcoma

KW - p-borono--phenylalanine (L-BPA)

KW - VA-ES-BJ

UR - https://www.scopus.com/pages/publications/105003961011

UR - https://www.scopus.com/pages/publications/105003961011#tab=citedBy

U2 - 10.1016/j.apradiso.2025.111846

DO - 10.1016/j.apradiso.2025.111846

M3 - Article

C2 - 40319847

AN - SCOPUS:105003961011

SN - 0969-8043

VL - 222

JO - Applied Radiation and Isotopes

JF - Applied Radiation and Isotopes

M1 - 111846

ER -

Potential of boron neutron capture therapy (BNCT) for epithelioid sarcoma

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this