Abstract
Malignant peripheral nerve sheath tumors (MPNST) are relatively rare neoplasms with poor prognosis. At present there is no effective treatment for MPNST other than surgical resection. Nonetheless, the anti-tumor effect of boron neutron capture therapy (BNCT) was recently demonstrated in two patients with MPNST. Subsequently, tumor-bearing nude mice subcutaneously transplanted with a human MPNST cell line were injected with p-borono-L-phenylalanine (L-BPA) and subjected to BNCT. Pathological studies then revealed that the MPNST cells were selectively destroyed by BNCT.
Original language | English |
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Pages (from-to) | 220-225 |
Number of pages | 6 |
Journal | Applied Radiation and Isotopes |
Volume | 106 |
DOIs | |
Publication status | Published - 01-12-2015 |
Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Radiation