Potential of boron neutron capture therapy (BNCT) for malignant peripheral nerve sheath tumors (MPNST)

Takuya Fujimoto, Tooru Andoh, Tamotsu Sudo, Ikuo Fujita, Naomasa Fukase, Tamotsu Takeuchi, Hiroshi Sonobe, Masayoshi Inoue, Tkanori Hirose, Toshiko Sakuma, Hiroshi Moritake, Tohru Sugimoto, Teruya Kawamoto, Yoshinobu Fukumori, Satomi Yamamoto, Shinji Atagi, Yoshinori Sakurai, Masahiro Kurosaka, Koji Ono, Hideki IchikawaMinoru Suzuki

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

Malignant peripheral nerve sheath tumors (MPNST) are relatively rare neoplasms with poor prognosis. At present there is no effective treatment for MPNST other than surgical resection. Nonetheless, the anti-tumor effect of boron neutron capture therapy (BNCT) was recently demonstrated in two patients with MPNST. Subsequently, tumor-bearing nude mice subcutaneously transplanted with a human MPNST cell line were injected with p-borono-L-phenylalanine (L-BPA) and subjected to BNCT. Pathological studies then revealed that the MPNST cells were selectively destroyed by BNCT.

Original languageEnglish
Pages (from-to)220-225
Number of pages6
JournalApplied Radiation and Isotopes
Volume106
DOIs
Publication statusPublished - 01-12-2015
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Radiation

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