Potential of boron neutron capture therapy (BNCT) for myxofibrosarcoma

Takuya Fujimoto, Tooru Andoh, Tamotsu Sudo, Ikuo Fujita, Yoshinori Sakurai, Takushi Takata, Hiroki Tanaka, Teruya Kawamoto, Shunsuke Yahiro, Shotaro Nakamura, Hitomi Hara, Naomasa Fukase, Toshihiro Akisue, Hideki Ichikawa, Ryosuke Kuroda, Minoru Suzuki

Research output: Contribution to journalArticlepeer-review

Abstract

Myxofibrosarcoma, a rare malignant tumor, predominantly affects the extremities of the elderly. Because of its invasive nature amputation is sometimes required, resulting in serious deterioration of quality of life. Therefore, cell lines established from amputated surgical specimens of myxofibrosarcoma in the upper limbs of elderly patients were used to create a myxofibrosarcoma-bearing animal model and to investigate the therapeutic effect of BNCT thereon. The results demonstrated selective destruction of tumor cells, suggesting the anti-tumor efficacy of BNCT on myxofibrosarcoma.

Original languageEnglish
Article number111603
JournalApplied Radiation and Isotopes
Volume217
DOIs
Publication statusPublished - 03-2025

All Science Journal Classification (ASJC) codes

  • Radiation

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